Yessotoxin as an apoptotic inducer
This work summarises current knowledge on how the marine toxin yessotoxin (YTX) induces apoptosis in different types of cells. The work also addresses perspectives for future research on this topic. YTX triggers apoptosis in a variety of cellular systems including cancer cells. The actual apoptotic...
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| Veröffentlicht in: | Toxicon (Oxford) 2011-06, Vol.57 (7-8), p.947-958 |
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| container_issue | 7-8 |
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| container_title | Toxicon (Oxford) |
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| creator | Suárez Korsnes, Mónica Espenes, Arild |
| description | This work summarises current knowledge on how the marine toxin yessotoxin (YTX) induces apoptosis in different types of cells. The work also addresses perspectives for future research on this topic. YTX triggers apoptosis in a variety of cellular systems including cancer cells. The actual apoptotic pathways are not fully understood and seem to be cell-specific. YTX can induce the mitochondrial pathway in myoblast cell lines, but its potential to activate other signalling pathways and possible cross-talk between them has not been reported. Improvement in our understanding of death signalling induction by YTX may contribute to identifying novel molecular mechanisms of interest for therapeutic applications. |
| doi_str_mv | 10.1016/j.toxicon.2011.03.012 |
| format | Article |
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Antivenoms</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptotic signalling pathways</subject><subject>Biological and medical sciences</subject><subject>Caspases</subject><subject>Cell Line</subject><subject>death</subject><subject>Medical sciences</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>myoblasts</subject><subject>Myoblasts - drug effects</subject><subject>neoplasm cells</subject><subject>Oxocins - chemistry</subject><subject>Oxocins - toxicity</subject><subject>Plant poisons toxicology</subject><subject>signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Toxicology</subject><subject>Yessotoxin</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotl4eQS2CuJrx5DKZyUqkeIOCC-3CVUhzkZTppCZT0bc3pVWXbnI23_n_nA-hEwwlBsyv5mUfPr0OXUkA4xJoCZjsoCFualFQXMEuGgIwXEDGB-ggpTkA0EbwfTQgmBEuMBmi81ebUlhHdSOVRiq_y7DsQ-_1yHdmpW08QntOtckeb-chmt7dvowfisnT_eP4ZlJoVkFfNKZiSihCqVWUqZluaqCVUYQBMVVNNHOWU2eY5oI5hxtohGiM4kRwTqilh-hyk7uM4X1lUy8XPmnbtqqzYZWkyGfzfCzLZLUhdQwpRevkMvqFil8Sg1zbkXO5tSPXdiRQme3kvdNtw2q2sOZ360dHBi62gEpatS6qTvv0xzFSV5zgzJ1tOKeCVG8xM9Pn3FRBLhc5KxPXG8JmYx_eRpm0t522xkere2mC_-ez366ZjLc</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Suárez Korsnes, Mónica</creator><creator>Espenes, Arild</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20110601</creationdate><title>Yessotoxin as an apoptotic inducer</title><author>Suárez Korsnes, Mónica ; Espenes, Arild</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-8d54a9a233ea34abc87035da2402d572c4fe63fd4c694ff1808998da6296623e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animal poisons toxicology. 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| fulltext | fulltext |
| identifier | ISSN: 0041-0101 |
| ispartof | Toxicon (Oxford), 2011-06, Vol.57 (7-8), p.947-958 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal poisons toxicology. Antivenoms Apoptosis Apoptosis - drug effects Apoptotic signalling pathways Biological and medical sciences Caspases Cell Line death Medical sciences Mitochondria Mitochondria - drug effects myoblasts Myoblasts - drug effects neoplasm cells Oxocins - chemistry Oxocins - toxicity Plant poisons toxicology signal transduction Signal Transduction - drug effects Toxicology Yessotoxin |
| title | Yessotoxin as an apoptotic inducer |
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