Artificial metalloenzymes for olefin metathesis based on the biotin-(strept)avidin technology

Artificial metalloenzymes for olefin metathesis based on the biotin-(strept)avidin technology

Incorporation of a biotinylated Hoveyda-Grubbs catalyst within (strept)avidin affords artificial metalloenzymes for the ring-closing metathesis of N-tosyl diallylamine in aqueous solution. Optimization of the performance can be achieved either by chemical or genetic means.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-11, Vol.47 (44), p.12065-12067
Hauptverfasser: Lo, Cheikh, Ringenberg, Mark R, Gnandt, David, Wilson, Yvonne, Ward, Thomas R
Format: Artikel
Sprache:eng
Schlagworte:
Allyl Compounds - chemistry
Amines - chemistry
Aqueous solutions
Biotin - chemistry
Biotinylation
Catalysis
Catalysts
Decomposition reactions
Genetics
Metalloproteins - chemical synthesis
Metathesis
Olefins
Optimization
Ruthenium - chemistry
Streptavidin - chemistry
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Beschreibung
Zusammenfassung:Incorporation of a biotinylated Hoveyda-Grubbs catalyst within (strept)avidin affords artificial metalloenzymes for the ring-closing metathesis of N-tosyl diallylamine in aqueous solution. Optimization of the performance can be achieved either by chemical or genetic means.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc15004a