Non-muscle myosin IIA is required for the development of the zebrafish glomerulus

Mutations in the MYH9 gene, coding for the non-muscle myosin heavy chain IIA (NMHC-IIA), are responsible for syndromes characterized by macrothrombocytopenia associated with deafness, cataracts, and severe glomerular disease. Electron microscopy of renal biopsies from these patients found glomerular...

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Veröffentlicht in:	Kidney international 2011-11, Vol.80 (10), p.1055-1063
Hauptverfasser:	Müller, Tobias, Rumpel, Elisabeth, Hradetzky, Susanne, Bollig, Frank, Wegner, Henny, Blumenthal, Antje, Greinacher, Andreas, Endlich, Karlhans, Endlich, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Platelets - metabolism Danio rerio Dextrans - metabolism Edema - genetics Edema - metabolism Endothelial Cells - metabolism Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - metabolism Fluorescent Dyes - metabolism Freshwater Gene Expression Regulation, Developmental Gene Knockdown Techniques Genotype Glomerular Basement Membrane - metabolism glomerular filtration Glomerular Filtration Rate Heterocyclic Compounds, 4 or More Rings - pharmacology Kidney Glomerulus - abnormalities Kidney Glomerulus - blood supply Kidney Glomerulus - drug effects Kidney Glomerulus - metabolism Larva - genetics Larva - metabolism Medical sciences Myh9 Nephrology. Urinary tract diseases Nonmuscle Myosin Type IIA - antagonists & inhibitors Nonmuscle Myosin Type IIA - genetics Nonmuscle Myosin Type IIA - metabolism Permeability Phenotype podocyte Podocytes - metabolism pronephros Recombinant Proteins - metabolism Time Factors Zebrafish - abnormalities Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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