Scoring of late gadolinium enhancement in cardiac magnetic resonance imaging can predict cardiac events in patients with hypertrophic cardiomyopathy
Summary Background Late gadolinium enhancement (LGE) of cardiac magnetic resonance imaging (MRI) represents myocardial fibrosis and may be related to the clinical outcome of various heart diseases. This study evaluated the relationship between LGE and cardiac events in hypertrophic cardiomyopathy (H...
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| Veröffentlicht in: | Journal of cardiology 2011-11, Vol.58 (3), p.253-260 |
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| creator | Nojiri, Ayumi, MD Hongo, Kenichi, MD, PhD Kawai, Makoto, MD, PhD Komukai, Kimiaki, MD, PhD Sakuma, Toru, MD, PhD Taniguchi, Ikuo, MD, PhD Yoshimura, Michihiro, MD, PhD, FJCC |
| description | Summary Background Late gadolinium enhancement (LGE) of cardiac magnetic resonance imaging (MRI) represents myocardial fibrosis and may be related to the clinical outcome of various heart diseases. This study evaluated the relationship between LGE and cardiac events in hypertrophic cardiomyopathy (HCM) using a new scoring method. Methods and results This study retrospectively followed 46 HCM patients without heart failure symptoms for 3.8 ± 1.8 years. Gadolinium-enhanced cardiac MRI was performed in all patients. Cardiac events including newly developed heart failure or ventricular tachyarrhythmia were evaluated during the follow-up period. We evaluated the predictive factors to identify the patients with cardiac events. None of the risk factors reported to be related to poor outcome or the existence of LGE alone could predict cardiac events, which might be due to the small number of subjects investigated in this study. A new scoring method for LGE-positive areas (LGE score) was applied and higher LGE score can predict cardiac events in this study population. Conclusions The proposed LGE score for cardiac MRI is considered to be a potentially valid method for assessing cardiac events in HCM patients. |
| doi_str_mv | 10.1016/j.jjcc.2011.07.007 |
| format | Article |
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This study evaluated the relationship between LGE and cardiac events in hypertrophic cardiomyopathy (HCM) using a new scoring method. Methods and results This study retrospectively followed 46 HCM patients without heart failure symptoms for 3.8 ± 1.8 years. Gadolinium-enhanced cardiac MRI was performed in all patients. Cardiac events including newly developed heart failure or ventricular tachyarrhythmia were evaluated during the follow-up period. We evaluated the predictive factors to identify the patients with cardiac events. None of the risk factors reported to be related to poor outcome or the existence of LGE alone could predict cardiac events, which might be due to the small number of subjects investigated in this study. A new scoring method for LGE-positive areas (LGE score) was applied and higher LGE score can predict cardiac events in this study population. Conclusions The proposed LGE score for cardiac MRI is considered to be a potentially valid method for assessing cardiac events in HCM patients.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2011.07.007</identifier><identifier>PMID: 21890327</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; Cardiomyopathy, Hypertrophic - complications ; Cardiomyopathy, Hypertrophic - pathology ; Cardiovascular ; Family history ; Female ; Fibrosis ; Follow-Up Studies ; Forecasting ; Gadolinium ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - etiology ; Humans ; Image Enhancement - methods ; Left ventricular hypertrophy ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Myocardial fibrosis ; Myocardium - pathology ; Prognosis ; Retrospective Studies ; Risk Factors ; Tachycardia, Ventricular - diagnosis ; Tachycardia, Ventricular - etiology ; Ventricular arrhythmia</subject><ispartof>Journal of cardiology, 2011-11, Vol.58 (3), p.253-260</ispartof><rights>Japanese College of Cardiology</rights><rights>2011 Japanese College of Cardiology</rights><rights>Copyright © 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-48ca4215e9f4bf8fc0ba5bd92023c2c3db901b16856846239acdd052715aa3713</citedby><cites>FETCH-LOGICAL-c507t-48ca4215e9f4bf8fc0ba5bd92023c2c3db901b16856846239acdd052715aa3713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0914508711001304$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21890327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nojiri, Ayumi, MD</creatorcontrib><creatorcontrib>Hongo, Kenichi, MD, PhD</creatorcontrib><creatorcontrib>Kawai, Makoto, MD, PhD</creatorcontrib><creatorcontrib>Komukai, Kimiaki, MD, PhD</creatorcontrib><creatorcontrib>Sakuma, Toru, MD, PhD</creatorcontrib><creatorcontrib>Taniguchi, Ikuo, MD, PhD</creatorcontrib><creatorcontrib>Yoshimura, Michihiro, MD, PhD, FJCC</creatorcontrib><title>Scoring of late gadolinium enhancement in cardiac magnetic resonance imaging can predict cardiac events in patients with hypertrophic cardiomyopathy</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Summary Background Late gadolinium enhancement (LGE) of cardiac magnetic resonance imaging (MRI) represents myocardial fibrosis and may be related to the clinical outcome of various heart diseases. This study evaluated the relationship between LGE and cardiac events in hypertrophic cardiomyopathy (HCM) using a new scoring method. Methods and results This study retrospectively followed 46 HCM patients without heart failure symptoms for 3.8 ± 1.8 years. Gadolinium-enhanced cardiac MRI was performed in all patients. Cardiac events including newly developed heart failure or ventricular tachyarrhythmia were evaluated during the follow-up period. We evaluated the predictive factors to identify the patients with cardiac events. None of the risk factors reported to be related to poor outcome or the existence of LGE alone could predict cardiac events, which might be due to the small number of subjects investigated in this study. A new scoring method for LGE-positive areas (LGE score) was applied and higher LGE score can predict cardiac events in this study population. Conclusions The proposed LGE score for cardiac MRI is considered to be a potentially valid method for assessing cardiac events in HCM patients.</description><subject>Aged</subject><subject>Cardiomyopathy, Hypertrophic - complications</subject><subject>Cardiomyopathy, Hypertrophic - pathology</subject><subject>Cardiovascular</subject><subject>Family history</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Follow-Up Studies</subject><subject>Forecasting</subject><subject>Gadolinium</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - etiology</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Left ventricular hypertrophy</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial fibrosis</subject><subject>Myocardium - pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tachycardia, Ventricular - diagnosis</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Ventricular arrhythmia</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1u1TAQhSMEopfCC7BA3rFKGDs_TiSEhCr-pEosCmvLmUzudUjsYCdFeQ8eGKe3dMGClUfWd44050ySvOSQceDVmyEbBsRMAOcZyAxAPkoOvJZVWsi8fpwcoOFFWkItL5JnIQwAFTR19TS5ELxuIBfykPy-QeeNPTLXs1EvxI66c6OxZp0Y2ZO2SBPZhRnLUPvOaGSTPlpaDDJPwdmdYCb-7SaoLZs9dQaXB5xuoz7sBrNezN38yywndtpm8ot38yla3cFu2lxkTtvz5Emvx0Av7t_L5PvHD9-uPqfXXz99uXp_nWIJckmLGnUheElNX7R93SO0umy7RoDIUWDetQ3wlld1WdVFJfJGY9dBKSQvtc4lzy-T12ff2bufK4VFTSYgjaO25Nagorwq8qIuIynOJHoXgqdezT4u7TfFQe1lqEHtZai9DAVSxTKi6NW9_dpO1D1I_qYfgbdngOKSt4a8ChgTwhigJ1xU58z__d_9I8e9OdTjD9ooDG71NsanuApCgbrZz2G_Bs4BeA5F_gcPWbNA</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Nojiri, Ayumi, MD</creator><creator>Hongo, Kenichi, MD, PhD</creator><creator>Kawai, Makoto, MD, PhD</creator><creator>Komukai, Kimiaki, MD, PhD</creator><creator>Sakuma, Toru, MD, PhD</creator><creator>Taniguchi, Ikuo, MD, PhD</creator><creator>Yoshimura, Michihiro, MD, PhD, FJCC</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Scoring of late gadolinium enhancement in cardiac magnetic resonance imaging can predict cardiac events in patients with hypertrophic cardiomyopathy</title><author>Nojiri, Ayumi, MD ; Hongo, Kenichi, MD, PhD ; Kawai, Makoto, MD, PhD ; Komukai, Kimiaki, MD, PhD ; Sakuma, Toru, MD, PhD ; Taniguchi, Ikuo, MD, PhD ; Yoshimura, Michihiro, MD, PhD, FJCC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-48ca4215e9f4bf8fc0ba5bd92023c2c3db901b16856846239acdd052715aa3713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Cardiomyopathy, Hypertrophic - complications</topic><topic>Cardiomyopathy, Hypertrophic - pathology</topic><topic>Cardiovascular</topic><topic>Family history</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Follow-Up Studies</topic><topic>Forecasting</topic><topic>Gadolinium</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - etiology</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Left ventricular hypertrophy</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial fibrosis</topic><topic>Myocardium - pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tachycardia, Ventricular - diagnosis</topic><topic>Tachycardia, Ventricular - etiology</topic><topic>Ventricular arrhythmia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nojiri, Ayumi, MD</creatorcontrib><creatorcontrib>Hongo, Kenichi, MD, PhD</creatorcontrib><creatorcontrib>Kawai, Makoto, MD, PhD</creatorcontrib><creatorcontrib>Komukai, Kimiaki, MD, PhD</creatorcontrib><creatorcontrib>Sakuma, Toru, MD, PhD</creatorcontrib><creatorcontrib>Taniguchi, Ikuo, MD, PhD</creatorcontrib><creatorcontrib>Yoshimura, Michihiro, MD, PhD, FJCC</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nojiri, Ayumi, MD</au><au>Hongo, Kenichi, MD, PhD</au><au>Kawai, Makoto, MD, PhD</au><au>Komukai, Kimiaki, MD, PhD</au><au>Sakuma, Toru, MD, PhD</au><au>Taniguchi, Ikuo, MD, PhD</au><au>Yoshimura, Michihiro, MD, PhD, FJCC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scoring of late gadolinium enhancement in cardiac magnetic resonance imaging can predict cardiac events in patients with hypertrophic cardiomyopathy</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>58</volume><issue>3</issue><spage>253</spage><epage>260</epage><pages>253-260</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Summary Background Late gadolinium enhancement (LGE) of cardiac magnetic resonance imaging (MRI) represents myocardial fibrosis and may be related to the clinical outcome of various heart diseases. This study evaluated the relationship between LGE and cardiac events in hypertrophic cardiomyopathy (HCM) using a new scoring method. Methods and results This study retrospectively followed 46 HCM patients without heart failure symptoms for 3.8 ± 1.8 years. Gadolinium-enhanced cardiac MRI was performed in all patients. Cardiac events including newly developed heart failure or ventricular tachyarrhythmia were evaluated during the follow-up period. We evaluated the predictive factors to identify the patients with cardiac events. None of the risk factors reported to be related to poor outcome or the existence of LGE alone could predict cardiac events, which might be due to the small number of subjects investigated in this study. A new scoring method for LGE-positive areas (LGE score) was applied and higher LGE score can predict cardiac events in this study population. Conclusions The proposed LGE score for cardiac MRI is considered to be a potentially valid method for assessing cardiac events in HCM patients.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>21890327</pmid><doi>10.1016/j.jjcc.2011.07.007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Cardiomyopathy, Hypertrophic - complications Cardiomyopathy, Hypertrophic - pathology Cardiovascular Family history Female Fibrosis Follow-Up Studies Forecasting Gadolinium Heart failure Heart Failure - diagnosis Heart Failure - etiology Humans Image Enhancement - methods Left ventricular hypertrophy Magnetic Resonance Imaging - methods Male Middle Aged Myocardial fibrosis Myocardium - pathology Prognosis Retrospective Studies Risk Factors Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - etiology Ventricular arrhythmia |
| title | Scoring of late gadolinium enhancement in cardiac magnetic resonance imaging can predict cardiac events in patients with hypertrophic cardiomyopathy |
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