Hydroxyapatite/polylactide biphasic combination scaffold loaded with dexamethasone for bone regeneration

This study presents a novel design of a ceramic/polymer biphasic combination scaffold that mimics natural bone structures and is used as a bone graft substitute. To mimic the natural bone structures, the outside cortical‐like shells were composed of porous hydroxyapatite (HA) with a hollow interior...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2011-12, Vol.99A (4), p.638-647
Hauptverfasser:	Son, Jun-Sik, Kim, Su-Gwan, Oh, Ji-Su, Appleford, Mark, Oh, Sunho, Ong, Joo L, Lee, Kyu-Bok
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - chemistry Biological and medical sciences Bone and Bones - metabolism Bone and Bones - ultrastructure Bone Regeneration - drug effects Bone Substitutes - chemistry Cell Line dexamethasone Dexamethasone - metabolism Dexamethasone - pharmacology dexamethasone, HEPM cell Drug Carriers - chemistry Drug Delivery Systems Durapatite - chemistry Glucocorticoids - metabolism Glucocorticoids - pharmacology HEPM cell Humans hydroxyapatite L-lactic acid Materials Testing Medical sciences micro-computed tomography analysis Orthopedic surgery Osteoblasts - drug effects Osteoblasts - physiology Osteoblasts - ultrastructure poly(D poly(D,L‐lactic acid) Polyesters - chemistry scaffold Surface Properties Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tissue Engineering - methods Tissue Scaffolds - chemistry X-Ray Microtomography
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