Decreased active GLP-1 response following large test meal in patients with type 1 diabetes using bolus insulin analogues

Postprandial plasma immunoreactive active glucagon-like peptide-1 (p-active GLP-1) levels in type 1 diabetic patients who did not use bolus insulin responded normally following ingestion of test meal, while a small response of p-active GLP-1 levels was seen in type 2 diabetic patients. To determine...

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Veröffentlicht in:	Endocrine Journal 2011, Vol.58(10), pp.905-911
Hauptverfasser:	Kamoi, Kyuzi, Shinozaki, You, Furukawa, Kazuo, Sasaki, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Active glucagon-like peptide-1 Biphasic Insulins - administration & dosage Biphasic Insulins - blood Biphasic Insulins - pharmacokinetics Biphasic Insulins - therapeutic use Blood Glucose - analysis C-Peptide - blood C-peptide immunoreactivity Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Female Glucagon-Like Peptide 1 - blood Glycated Hemoglobin A - analysis Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics Hypoglycemic Agents - therapeutic use Insulin Insulin - blood Insulin, Short-Acting - administration & dosage Insulin, Short-Acting - blood Insulin, Short-Acting - pharmacokinetics Insulin, Short-Acting - therapeutic use Male Middle Aged Postprandial Period Test meal Type 1 diabetes mellitus
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