Nephrotic syndrome unfavorable course correlates with downregulation of podocyte vascular endothelial growth factor receptor (VEGFR)-2

Idiopathic nephrotic syndrome (INS) in children is most commonly caused by primary glomerulopathies. Morphological lesions observed in INS might be secondary to inflammatory factors of mainly extra-renal origin. The vascular endothelial growth factor (VEGF) family is regarded as playing a crucial ro...

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Veröffentlicht in:	Folia histochemica et cytobiologica 2011-01, Vol.49 (3), p.472-478
Hauptverfasser:	Ostalska-Nowicka, Danuta, Malinska, Agnieszka, Zabel, Maciej, Witkiewicz, Wojciech, Nowicki, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antibodies Child Child, Preschool Children Cytoplasm Disease Progression Down-Regulation Electron microscopy Female Growth factors Humans Immunohistochemistry Inflammation Kidney diseases Male Monoclonal antibodies Nephrotic syndrome Nephrotic Syndrome - pathology Nephrotic Syndrome - physiopathology Overexpression Podocytes - metabolism Podocytes - ultrastructure Protein Isoforms - metabolism Receptors Signal Transduction - physiology Steroid hormones Vascular endothelial growth factor Vascular Endothelial Growth Factor C - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors
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