Circulating microRNA expression is reduced in chronic kidney disease
Background. MicroRNAs (miRNAs) are important regulators of gene expression, which have roles in renal development and disease. They exist in biological fluids including blood and urine and may have signalling roles and potential as disease biomarkers. Methods. We measured the levels of miRNAs in pat...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2011-11, Vol.26 (11), p.3794-3802 |
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| creator | Neal, Calida S. Michael, Michael Z. Pimlott, Letitia K. Yong, Tuck Y. Li, Jordan Y.Z. Gleadle, Jonathan M. |
| description | Background. MicroRNAs (miRNAs) are important regulators of gene expression, which have roles in renal development and disease. They exist in biological fluids including blood and urine and may have signalling roles and potential as disease biomarkers.
Methods. We measured the levels of miRNAs in patients with different stages of chronic kidney failure including those receiving maintenance haemodialysis treatment.
Results. In patients with severe chronic renal failure, circulating levels of total and specific miRNAs are reduced in comparison to patients with mild renal impairment or normal renal function. A strong correlation exists between detected circulating miRNAs and estimated glomerular filtration rate, and less strong correlations with other features of chronic kidney disease, such as anaemia and hyperparathyroidism.
Conclusion. These findings have important implications for the use of circulating miRNAs as biomarkers in individuals with renal impairment and for the pathogenesis of uraemia. |
| doi_str_mv | 10.1093/ndt/gfr485 |
| format | Article |
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Methods. We measured the levels of miRNAs in patients with different stages of chronic kidney failure including those receiving maintenance haemodialysis treatment.
Results. In patients with severe chronic renal failure, circulating levels of total and specific miRNAs are reduced in comparison to patients with mild renal impairment or normal renal function. A strong correlation exists between detected circulating miRNAs and estimated glomerular filtration rate, and less strong correlations with other features of chronic kidney disease, such as anaemia and hyperparathyroidism.
Conclusion. These findings have important implications for the use of circulating miRNAs as biomarkers in individuals with renal impairment and for the pathogenesis of uraemia.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfr485</identifier><identifier>PMID: 21891774</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anemia ; Anemia - etiology ; Anemia - pathology ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers - analysis ; Emergency and intensive care: renal failure. Dialysis management ; Exosomes - genetics ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Hyperparathyroidism - etiology ; Hyperparathyroidism - pathology ; Intensive care medicine ; Kidney Failure, Chronic - genetics ; Kidney Failure, Chronic - pathology ; Kidney Failure, Chronic - surgery ; Kidney Function Tests ; Kidneys ; Male ; Medical sciences ; MicroRNAs - physiology ; Middle Aged ; Neoplastic Cells, Circulating - pathology ; Nephrology. Urinary tract diseases ; Prognosis ; Real-Time Polymerase Chain Reaction ; Renal Dialysis ; Tumors of the urinary system ; Uremia - etiology ; Uremia - pathology</subject><ispartof>Nephrology, dialysis, transplantation, 2011-11, Vol.26 (11), p.3794-3802</ispartof><rights>The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-b714bfc0a6c4bf082ffe73b5a63b95c4fae31722a31fddd5b1b86aec32edecc23</citedby><cites>FETCH-LOGICAL-c481t-b714bfc0a6c4bf082ffe73b5a63b95c4fae31722a31fddd5b1b86aec32edecc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24740162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21891774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neal, Calida S.</creatorcontrib><creatorcontrib>Michael, Michael Z.</creatorcontrib><creatorcontrib>Pimlott, Letitia K.</creatorcontrib><creatorcontrib>Yong, Tuck Y.</creatorcontrib><creatorcontrib>Li, Jordan Y.Z.</creatorcontrib><creatorcontrib>Gleadle, Jonathan M.</creatorcontrib><title>Circulating microRNA expression is reduced in chronic kidney disease</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Background. MicroRNAs (miRNAs) are important regulators of gene expression, which have roles in renal development and disease. They exist in biological fluids including blood and urine and may have signalling roles and potential as disease biomarkers.
Methods. We measured the levels of miRNAs in patients with different stages of chronic kidney failure including those receiving maintenance haemodialysis treatment.
Results. In patients with severe chronic renal failure, circulating levels of total and specific miRNAs are reduced in comparison to patients with mild renal impairment or normal renal function. A strong correlation exists between detected circulating miRNAs and estimated glomerular filtration rate, and less strong correlations with other features of chronic kidney disease, such as anaemia and hyperparathyroidism.
Conclusion. These findings have important implications for the use of circulating miRNAs as biomarkers in individuals with renal impairment and for the pathogenesis of uraemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia</subject><subject>Anemia - etiology</subject><subject>Anemia - pathology</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Exosomes - genetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hyperparathyroidism - etiology</subject><subject>Hyperparathyroidism - pathology</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - genetics</subject><subject>Kidney Failure, Chronic - pathology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Function Tests</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MicroRNAs - physiology</subject><subject>Middle Aged</subject><subject>Neoplastic Cells, Circulating - pathology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Renal Dialysis</subject><subject>Tumors of the urinary system</subject><subject>Uremia - etiology</subject><subject>Uremia - pathology</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LwzAYwPEgipvTix9AehFFqMtL27THMV9hKIieS5o8mdE2rUkL7tsb2XS3nZ5Dfjzh-SN0SvA1wQWbWtVPl9olebqHxiTJcExZnu6jcXgkMU5xMUJH3n9gjAvK-SEaUZIXhPNkjG7mxsmhFr2xy6gx0rUvT7MIvjsH3pvWRsZHDtQgQUXGRvLdtdbI6NMoC6tIGQ_CwzE60KL2cLKZE_R2d_s6f4gXz_eP89kilklO-rjiJKm0xCKTYeKcag2cVanIWFWkMtECGOGUCka0UiqtSJVnAiSjoEBKyiboYr23c-3XAL4vG-Ml1LWw0A6-LDBh4dyMBHm5U4ZKOeN5SotAr9Y03O69A112zjTCrUqCy9--ZehbrvsGfLbZO1QNqH_6FzSA8w0QXopaO2Gl8VuX8ASTjG5dO3S7PvwBP8yRLA</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Neal, Calida S.</creator><creator>Michael, Michael Z.</creator><creator>Pimlott, Letitia K.</creator><creator>Yong, Tuck Y.</creator><creator>Li, Jordan Y.Z.</creator><creator>Gleadle, Jonathan M.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Circulating microRNA expression is reduced in chronic kidney disease</title><author>Neal, Calida S. ; Michael, Michael Z. ; Pimlott, Letitia K. ; Yong, Tuck Y. ; Li, Jordan Y.Z. ; Gleadle, Jonathan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-b714bfc0a6c4bf082ffe73b5a63b95c4fae31722a31fddd5b1b86aec32edecc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia</topic><topic>Anemia - etiology</topic><topic>Anemia - pathology</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Exosomes - genetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hyperparathyroidism - etiology</topic><topic>Hyperparathyroidism - pathology</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - genetics</topic><topic>Kidney Failure, Chronic - pathology</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Function Tests</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MicroRNAs - physiology</topic><topic>Middle Aged</topic><topic>Neoplastic Cells, Circulating - pathology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Renal Dialysis</topic><topic>Tumors of the urinary system</topic><topic>Uremia - etiology</topic><topic>Uremia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neal, Calida S.</creatorcontrib><creatorcontrib>Michael, Michael Z.</creatorcontrib><creatorcontrib>Pimlott, Letitia K.</creatorcontrib><creatorcontrib>Yong, Tuck Y.</creatorcontrib><creatorcontrib>Li, Jordan Y.Z.</creatorcontrib><creatorcontrib>Gleadle, Jonathan M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neal, Calida S.</au><au>Michael, Michael Z.</au><au>Pimlott, Letitia K.</au><au>Yong, Tuck Y.</au><au>Li, Jordan Y.Z.</au><au>Gleadle, Jonathan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating microRNA expression is reduced in chronic kidney disease</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>26</volume><issue>11</issue><spage>3794</spage><epage>3802</epage><pages>3794-3802</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. MicroRNAs (miRNAs) are important regulators of gene expression, which have roles in renal development and disease. They exist in biological fluids including blood and urine and may have signalling roles and potential as disease biomarkers.
Methods. We measured the levels of miRNAs in patients with different stages of chronic kidney failure including those receiving maintenance haemodialysis treatment.
Results. In patients with severe chronic renal failure, circulating levels of total and specific miRNAs are reduced in comparison to patients with mild renal impairment or normal renal function. A strong correlation exists between detected circulating miRNAs and estimated glomerular filtration rate, and less strong correlations with other features of chronic kidney disease, such as anaemia and hyperparathyroidism.
Conclusion. These findings have important implications for the use of circulating miRNAs as biomarkers in individuals with renal impairment and for the pathogenesis of uraemia.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21891774</pmid><doi>10.1093/ndt/gfr485</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Anemia Anemia - etiology Anemia - pathology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - analysis Emergency and intensive care: renal failure. Dialysis management Exosomes - genetics Female Follow-Up Studies Glomerular Filtration Rate Humans Hyperparathyroidism - etiology Hyperparathyroidism - pathology Intensive care medicine Kidney Failure, Chronic - genetics Kidney Failure, Chronic - pathology Kidney Failure, Chronic - surgery Kidney Function Tests Kidneys Male Medical sciences MicroRNAs - physiology Middle Aged Neoplastic Cells, Circulating - pathology Nephrology. Urinary tract diseases Prognosis Real-Time Polymerase Chain Reaction Renal Dialysis Tumors of the urinary system Uremia - etiology Uremia - pathology |
| title | Circulating microRNA expression is reduced in chronic kidney disease |
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