A Rare Case of Cryptococcal Infection of Talus with Pathological Fracture That Healed with Medical Management
Abstract Skeletal involvement occurs in 5% to 10% of reported cases of disseminated cryptococcal infection. We are reporting a very rare presentation of cryptococcal infection of the talus with pathological fracture, which healed with medical management. Our patient had pain and swelling around the...
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| Veröffentlicht in: | The Journal of foot and ankle surgery 2011-11, Vol.50 (6), p.740-743 |
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| container_title | The Journal of foot and ankle surgery |
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| creator | Balaji, G. Gopisankar, MS Ortho Mathuram, Alice Joan, MD GenMed Arockiaraj, Justin, SV MSOrtho Varghese, George M., MD GenMed |
| description | Abstract Skeletal involvement occurs in 5% to 10% of reported cases of disseminated cryptococcal infection. We are reporting a very rare presentation of cryptococcal infection of the talus with pathological fracture, which healed with medical management. Our patient had pain and swelling around the ankle associated with fever. Radiologically, he had a lytic lesion of the talus with fracture of the talar neck. Biopsy and cultures revealed cryptococcal infection. He was treated with surgical debridement combined with antifungal therapy, and the fracture healed well by 5 months. At the end of the 1-year follow-up, he had painless ankle movement and there was no evidence of recurrence. He was able to walk without support or limp, and he could wear normal footwear. |
| doi_str_mv | 10.1053/j.jfas.2011.06.016 |
| format | Article |
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Gopisankar, MS Ortho ; Mathuram, Alice Joan, MD GenMed ; Arockiaraj, Justin, SV MSOrtho ; Varghese, George M., MD GenMed</creator><creatorcontrib>Balaji, G. Gopisankar, MS Ortho ; Mathuram, Alice Joan, MD GenMed ; Arockiaraj, Justin, SV MSOrtho ; Varghese, George M., MD GenMed</creatorcontrib><description>Abstract Skeletal involvement occurs in 5% to 10% of reported cases of disseminated cryptococcal infection. We are reporting a very rare presentation of cryptococcal infection of the talus with pathological fracture, which healed with medical management. Our patient had pain and swelling around the ankle associated with fever. Radiologically, he had a lytic lesion of the talus with fracture of the talar neck. Biopsy and cultures revealed cryptococcal infection. He was treated with surgical debridement combined with antifungal therapy, and the fracture healed well by 5 months. At the end of the 1-year follow-up, he had painless ankle movement and there was no evidence of recurrence. He was able to walk without support or limp, and he could wear normal footwear.</description><identifier>ISSN: 1067-2516</identifier><identifier>EISSN: 1542-2224</identifier><identifier>DOI: 10.1053/j.jfas.2011.06.016</identifier><identifier>PMID: 21820328</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ankle ; Antifungal Agents - therapeutic use ; azathioprine ; Biological and medical sciences ; Biopsy, Needle ; Combined Modality Therapy ; Cryptococcosis - complications ; Cryptococcosis - diagnosis ; Cryptococcosis - drug therapy ; Cryptococcus ; Debridement - methods ; Diseases of the osteoarticular system ; Follow-Up Studies ; Fractures, Bone - diagnostic imaging ; Fractures, Bone - etiology ; Fractures, Bone - surgery ; Fractures, Spontaneous - diagnostic imaging ; Fractures, Spontaneous - etiology ; Fractures, Spontaneous - therapy ; fungal infection ; Fungemia - complications ; Fungemia - diagnosis ; Fungemia - drug therapy ; Human mycoses ; Humans ; Immunohistochemistry ; immunosuppression ; Infectious diseases ; Injuries of the limb. Injuries of the spine ; Male ; Medical sciences ; Middle Aged ; Miscellaneous mycoses ; Mycoses ; Orthopedics ; prednisolone ; Radiography ; Rare Diseases ; Risk Assessment ; surgery ; Talus - diagnostic imaging ; Talus - injuries ; Traumas. Diseases due to physical agents ; Treatment Outcome</subject><ispartof>The Journal of foot and ankle surgery, 2011-11, Vol.50 (6), p.740-743</ispartof><rights>American College of Foot and Ankle Surgeons</rights><rights>2011 American College of Foot and Ankle Surgeons</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-8354a4175182c640c72ea142ae9c52c5e8c758a5f6a97a5fac178a4265cd0d243</citedby><cites>FETCH-LOGICAL-c440t-8354a4175182c640c72ea142ae9c52c5e8c758a5f6a97a5fac178a4265cd0d243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/j.jfas.2011.06.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24819401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21820328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balaji, G. Gopisankar, MS Ortho</creatorcontrib><creatorcontrib>Mathuram, Alice Joan, MD GenMed</creatorcontrib><creatorcontrib>Arockiaraj, Justin, SV MSOrtho</creatorcontrib><creatorcontrib>Varghese, George M., MD GenMed</creatorcontrib><title>A Rare Case of Cryptococcal Infection of Talus with Pathological Fracture That Healed with Medical Management</title><title>The Journal of foot and ankle surgery</title><addtitle>J Foot Ankle Surg</addtitle><description>Abstract Skeletal involvement occurs in 5% to 10% of reported cases of disseminated cryptococcal infection. We are reporting a very rare presentation of cryptococcal infection of the talus with pathological fracture, which healed with medical management. Our patient had pain and swelling around the ankle associated with fever. Radiologically, he had a lytic lesion of the talus with fracture of the talar neck. Biopsy and cultures revealed cryptococcal infection. He was treated with surgical debridement combined with antifungal therapy, and the fracture healed well by 5 months. At the end of the 1-year follow-up, he had painless ankle movement and there was no evidence of recurrence. He was able to walk without support or limp, and he could wear normal footwear.</description><subject>ankle</subject><subject>Antifungal Agents - therapeutic use</subject><subject>azathioprine</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Combined Modality Therapy</subject><subject>Cryptococcosis - complications</subject><subject>Cryptococcosis - diagnosis</subject><subject>Cryptococcosis - drug therapy</subject><subject>Cryptococcus</subject><subject>Debridement - methods</subject><subject>Diseases of the osteoarticular system</subject><subject>Follow-Up Studies</subject><subject>Fractures, Bone - diagnostic imaging</subject><subject>Fractures, Bone - etiology</subject><subject>Fractures, Bone - surgery</subject><subject>Fractures, Spontaneous - diagnostic imaging</subject><subject>Fractures, Spontaneous - etiology</subject><subject>Fractures, Spontaneous - therapy</subject><subject>fungal infection</subject><subject>Fungemia - complications</subject><subject>Fungemia - diagnosis</subject><subject>Fungemia - drug therapy</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>immunosuppression</subject><subject>Infectious diseases</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous mycoses</subject><subject>Mycoses</subject><subject>Orthopedics</subject><subject>prednisolone</subject><subject>Radiography</subject><subject>Rare Diseases</subject><subject>Risk Assessment</subject><subject>surgery</subject><subject>Talus - diagnostic imaging</subject><subject>Talus - injuries</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Treatment Outcome</subject><issn>1067-2516</issn><issn>1542-2224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ktGK1DAUhoMo7jr6Al5Ib8Sr1iRN2hREWAbXXdhF0RG8C8fT053UTjMmrTJvb-qMCl54dQL5_p_Dx2HsqeCF4Lp82Rd9B7GQXIiCVwUX1T12LrSSuZRS3U9vXtW51KI6Y49i7DmXsjH6ITuTwkheSnPOdhfZBwiUrSFS5rtsHQ77yaNHhCG7HjvCyflx-dnAMMfsh5u22XuYtn7wd26BLgPgNKeKzRam7IpgoPaI3VL7i7iFEe5oR-P0mD3oYIj05DRX7NPlm836Kr959_Z6fXGTo1J8yk2pFShR67QmVopjLQmEkkANaomaDNbagO4qaOo0AEVtQMlKY8tbqcoVe3Hs3Qf_baY42Z2LSMMAI_k52oaLkitTm0TKI4nBxxios_vgdhAOVnC7WLa9XSzbxbLllU2WU-jZqX7-sqP2T-S31gQ8PwEQk4EuwIgu_uWUEY1KO6zYqyNHScZ3R8FGdDRiEheSedt69_89Xv8Tx8GNi_OvdKDY-zmMSbMVNkrL7cflHpZzEILz0qjP5U_ao67w</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Balaji, G. Gopisankar, MS Ortho</creator><creator>Mathuram, Alice Joan, MD GenMed</creator><creator>Arockiaraj, Justin, SV MSOrtho</creator><creator>Varghese, George M., MD GenMed</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>A Rare Case of Cryptococcal Infection of Talus with Pathological Fracture That Healed with Medical Management</title><author>Balaji, G. Gopisankar, MS Ortho ; Mathuram, Alice Joan, MD GenMed ; Arockiaraj, Justin, SV MSOrtho ; Varghese, George M., MD GenMed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-8354a4175182c640c72ea142ae9c52c5e8c758a5f6a97a5fac178a4265cd0d243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ankle</topic><topic>Antifungal Agents - therapeutic use</topic><topic>azathioprine</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Combined Modality Therapy</topic><topic>Cryptococcosis - complications</topic><topic>Cryptococcosis - diagnosis</topic><topic>Cryptococcosis - drug therapy</topic><topic>Cryptococcus</topic><topic>Debridement - methods</topic><topic>Diseases of the osteoarticular system</topic><topic>Follow-Up Studies</topic><topic>Fractures, Bone - diagnostic imaging</topic><topic>Fractures, Bone - etiology</topic><topic>Fractures, Bone - surgery</topic><topic>Fractures, Spontaneous - diagnostic imaging</topic><topic>Fractures, Spontaneous - etiology</topic><topic>Fractures, Spontaneous - therapy</topic><topic>fungal infection</topic><topic>Fungemia - complications</topic><topic>Fungemia - diagnosis</topic><topic>Fungemia - drug therapy</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>immunosuppression</topic><topic>Infectious diseases</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous mycoses</topic><topic>Mycoses</topic><topic>Orthopedics</topic><topic>prednisolone</topic><topic>Radiography</topic><topic>Rare Diseases</topic><topic>Risk Assessment</topic><topic>surgery</topic><topic>Talus - diagnostic imaging</topic><topic>Talus - injuries</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balaji, G. 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Radiologically, he had a lytic lesion of the talus with fracture of the talar neck. Biopsy and cultures revealed cryptococcal infection. He was treated with surgical debridement combined with antifungal therapy, and the fracture healed well by 5 months. At the end of the 1-year follow-up, he had painless ankle movement and there was no evidence of recurrence. He was able to walk without support or limp, and he could wear normal footwear.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21820328</pmid><doi>10.1053/j.jfas.2011.06.016</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of foot and ankle surgery, 2011-11, Vol.50 (6), p.740-743 |
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| subjects | ankle Antifungal Agents - therapeutic use azathioprine Biological and medical sciences Biopsy, Needle Combined Modality Therapy Cryptococcosis - complications Cryptococcosis - diagnosis Cryptococcosis - drug therapy Cryptococcus Debridement - methods Diseases of the osteoarticular system Follow-Up Studies Fractures, Bone - diagnostic imaging Fractures, Bone - etiology Fractures, Bone - surgery Fractures, Spontaneous - diagnostic imaging Fractures, Spontaneous - etiology Fractures, Spontaneous - therapy fungal infection Fungemia - complications Fungemia - diagnosis Fungemia - drug therapy Human mycoses Humans Immunohistochemistry immunosuppression Infectious diseases Injuries of the limb. Injuries of the spine Male Medical sciences Middle Aged Miscellaneous mycoses Mycoses Orthopedics prednisolone Radiography Rare Diseases Risk Assessment surgery Talus - diagnostic imaging Talus - injuries Traumas. Diseases due to physical agents Treatment Outcome |
| title | A Rare Case of Cryptococcal Infection of Talus with Pathological Fracture That Healed with Medical Management |
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