mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome

Although podocyte damage is known to be responsible for the development of minimal-change disease (MCD), the underlying mechanism remains to be elucidated. Previously, using a rat MCD model, we showed that endoplasmic reticulum (ER) stress in the podocytes was associated with the heavy proteinuric s...

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Veröffentlicht in:	Laboratory investigation 2011-11, Vol.91 (11), p.1584-1595
Hauptverfasser:	Ito, Noriko, Nishibori, Yukino, Ito, Yugo, Takagi, Hisashi, Akimoto, Yoshihiro, Kudo, Akihiko, Asanuma, Katsuhiko, Sai, Yoshimichi, Miyamoto, Ken-ichi, Takenaka, Hitoshi, Yan, Kunimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/272/1684/1587/2101 631/80/86 692/699/1585 Animals Biological and medical sciences Biotechnology Blotting, Western Cells, Cultured Endoplasmic Reticulum Stress - physiology energy Everolimus Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Glomerulonephritis Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Medical sciences Medicine Medicine & Public Health Microscopy, Confocal mTOR Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nephrosis, Lipoid - etiology Nephrosis, Lipoid - metabolism Pathology podocyte Podocytes - metabolism Rats Real-Time Polymerase Chain Reaction research-article Reverse Transcriptase Polymerase Chain Reaction signaling Sirolimus - analogs & derivatives Statistics, Nonparametric TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Unfolded Protein Response - physiology UPR
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