Luminescent Ir(III) Complex Exclusively Made of Polypyridine Ligands Capable of Intercalating into Calf-Thymus DNA
Efficient intercalation of a luminescent Ir(III) complex exclusively made of polypyridine ligands in natural and synthetic biopolymers is reported for the first time. The emission of the complex is largely enhanced in the presence of [poly(dA–dT)2] and strongly quenched in the presence of [poly(dG–d...
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| Veröffentlicht in: | Inorganic chemistry 2011-11, Vol.50 (21), p.10667-10672 |
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| container_end_page | 10672 |
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| container_issue | 21 |
| container_start_page | 10667 |
| container_title | Inorganic chemistry |
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| creator | Campagna, Sebastiano Cavazzini, Marco Cusumano, Matteo Di Pietro, Maria Letizia Giannetto, Antonino Puntoriero, Fausto Quici, Silvio |
| description | Efficient intercalation of a luminescent Ir(III) complex exclusively made of polypyridine ligands in natural and synthetic biopolymers is reported for the first time. The emission of the complex is largely enhanced in the presence of [poly(dA–dT)2] and strongly quenched in the presence of [poly(dG–dC)2]. By comparing the emission decays in DNA and in synthetic polynucleotides, it is proposed that the emission quenching of the title compound by guanine residues in DNA is no longer effective over a distance of four dA–dT base pairs. |
| doi_str_mv | 10.1021/ic2010437 |
| format | Article |
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The emission of the complex is largely enhanced in the presence of [poly(dA–dT)2] and strongly quenched in the presence of [poly(dG–dC)2]. 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| ispartof | Inorganic chemistry, 2011-11, Vol.50 (21), p.10667-10672 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Biopolymers - chemistry Biopolymers - metabolism Circular Dichroism DNA - metabolism Intercalating Agents - analysis Intercalating Agents - chemical synthesis Intercalating Agents - metabolism Iridium - chemistry Ligands Luminescence Models, Molecular Molecular Probes - analysis Molecular Probes - chemical synthesis Molecular Probes - metabolism Poly dA-dT - chemistry Poly dA-dT - metabolism Polydeoxyribonucleotides - chemistry Polydeoxyribonucleotides - metabolism Polymerization Polynucleotides - chemistry Polynucleotides - metabolism Pyridines - chemistry |
| title | Luminescent Ir(III) Complex Exclusively Made of Polypyridine Ligands Capable of Intercalating into Calf-Thymus DNA |
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