Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin

A unique 30‐residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius (Oxyopidae). Oxt 4a contains a single N‐terminally located disulfide bond, Cys4–Cys10, and is structurally different from any spider toxin studied so far. According to NMR findi...

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Veröffentlicht in:	The FEBS journal 2011-11, Vol.278 (22), p.4382-4393
Hauptverfasser:	Dubovskii, Peter V., Vassilevski, Alexander A., Samsonova, Olga V., Egorova, Natalya S., Kozlov, Sergey A., Feofanov, Alexei V., Arseniev, Alexander S., Grishin, Eugene V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Anura Araneae Bacteria - drug effects Biochemistry Biosynthesis Circular Dichroism Cloning, Molecular Crystallography, X-Ray cytolytic peptide Frogs Hemolysis - drug effects Insecticides - pharmacology Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Oxyopidae Peptides precursor Protein Structure, Tertiary Rana‐box Ranidae Sequence Homology, Amino Acid Skin - metabolism spatial structure spider venom Spider Venoms - chemistry Spider Venoms - pharmacology Spiders Toxins
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