Is rat an appropriate animal model to study the involvement of d‐serine catabolism in schizophrenia? insights from characterization of d‐amino acid oxidase

d‐Amino acid oxidase (DAAO; EC1.4.3.3) has been proposed to play a main role in the degradation of d‐serine, an allosteric activator of the N‐methyl‐d‐aspartate‐type glutamate receptor in the human brain, and to be associated with the onset of schizophrenia. To prevent excessive d‐serine degradation...

Ausführliche Beschreibung