Effect of formulation parameters on the drug release and floating properties of gastric floating two-layer tablets with acetylsalicylic acid

Floating dosage forms of acetylsalicylic acid, used for its antithrombotic effect, were developed to prolong gastric residence time and increase bioavailability. In the two-layer tablet formulation, hydroxypropyl methylcellulose (HPMC) of high viscosity and an effervescent mixture of citric acid and...

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Veröffentlicht in:	Acta pharmaceutica (Zagreb, Croatia) Croatia), 2011-09, Vol.61 (3), p.303-312
Hauptverfasser:	Hasçiçek, Canan, Yüksel-Tilkan, Günseli, Türkmen, Berna, Özdemir, Nurten
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylsalicylic acid Aspirin - chemistry Aspirin - metabolism Biological Availability chitosan Chitosan - chemistry Citric Acid - chemistry Delayed-Action Preparations - chemistry Delayed-Action Preparations - metabolism Drug Compounding - methods Drug Delivery Systems dvoslojne plutajuće tablete Excipients - chemistry Fibrinolytic Agents - chemistry Fibrinolytic Agents - metabolism gastric retention hidroksipropil metilceluloza Humans hydroxypropyl methylcellulose Hypromellose Derivatives kitozan Methylcellulose - analogs & derivatives Methylcellulose - chemistry Models, Theoretical Polymers - chemistry Pressure Sodium Bicarbonate - chemistry Solubility Stomach - chemistry Stomach - metabolism Tablets - chemistry Time Factors two-layer floating tablet Viscosity zadržavanje u želucu
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