Structure and in Vitro Antiparasitic Activity of Constituents of Citropsis articulata Root Bark
From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heteroc...
Gespeichert in:
| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2011-10, Vol.74 (10), p.2286-2289 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2289 |
|---|---|
| container_issue | 10 |
| container_start_page | 2286 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 74 |
| creator | Lacroix, Damien Prado, Soizic Kamoga, Dennis Kasenene, John Bodo, Bernard |
| description | From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL. |
| doi_str_mv | 10.1021/np2004825 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_901005228</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>901005228</sourcerecordid><originalsourceid>FETCH-LOGICAL-a443t-506618059e7f6a34fe80d73d73edf8108c25200dd344fb670caccfe6f303aba03</originalsourceid><addsrcrecordid>eNp90U9rFDEYBvAgFbutHvwCkkupPYy--TebPW4XW4WCoK3X4d1MAtnOJtMkI_TbN2vX1YMIgRD48STvE0LeMvjAgLOPYeQAUnP1gsyY4tC0wNURmQFrRSN0K4_JSc4bABCwUK_IMWcLraCFGem-lzSZMiVLMfTUB_rDlxTpMhQ_YsLsizd0aYr_6csjjY6uYsjFl8mGkn-dd37MPlNM1U4DFqTfYiz0EtP9a_LS4ZDtm_1-Su6uPt2uPjc3X6-_rJY3DUopSlMf0zINamHnrkUhndXQz0VdtneagTa8zgV9L6R063YOBo1xtnUCBK4RxCk5f84dU3yYbC7d1mdjhwGDjVPuFsAAFOe6yvf_lbVAKUEpvQu9eKYmxZyTdd2Y_BbTY8eg2zXfHZqv9t0-dlpvbX-Qv6uu4GwPMBscXMJgfP7j5FzW7_rLocndJk4p1N7-ceET5CWWeQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1524405580</pqid></control><display><type>article</type><title>Structure and in Vitro Antiparasitic Activity of Constituents of Citropsis articulata Root Bark</title><source>MEDLINE</source><source>ACS Publications</source><creator>Lacroix, Damien ; Prado, Soizic ; Kamoga, Dennis ; Kasenene, John ; Bodo, Bernard</creator><creatorcontrib>Lacroix, Damien ; Prado, Soizic ; Kamoga, Dennis ; Kasenene, John ; Bodo, Bernard</creatorcontrib><description>From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np2004825</identifier><identifier>PMID: 21985060</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Northbrook, IL: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Alkaloids - chemistry ; Alkaloids - isolation & purification ; Animals ; Antimalarials - chemistry ; Antimalarials - isolation & purification ; Antimalarials - pharmacology ; Articulata ; Biological and medical sciences ; Cercopithecus aethiops ; Coumarins - chemistry ; Coumarins - isolation & purification ; Coumarins - pharmacology ; General pharmacology ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Inhibitory Concentration 50 ; Leishmania donovani - drug effects ; Medical sciences ; Parasitic Sensitivity Tests ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Roots - chemistry ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Rutaceae - chemistry ; Uganda ; Vero Cells</subject><ispartof>Journal of natural products (Washington, D.C.), 2011-10, Vol.74 (10), p.2286-2289</ispartof><rights>Copyright © 2011 American Chemical Society and American Society of Pharmacognosy</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a443t-506618059e7f6a34fe80d73d73edf8108c25200dd344fb670caccfe6f303aba03</citedby><cites>FETCH-LOGICAL-a443t-506618059e7f6a34fe80d73d73edf8108c25200dd344fb670caccfe6f303aba03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np2004825$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np2004825$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2764,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24741630$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21985060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lacroix, Damien</creatorcontrib><creatorcontrib>Prado, Soizic</creatorcontrib><creatorcontrib>Kamoga, Dennis</creatorcontrib><creatorcontrib>Kasenene, John</creatorcontrib><creatorcontrib>Bodo, Bernard</creatorcontrib><title>Structure and in Vitro Antiparasitic Activity of Constituents of Citropsis articulata Root Bark</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL.</description><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Animals</subject><subject>Antimalarials - chemistry</subject><subject>Antimalarials - isolation & purification</subject><subject>Antimalarials - pharmacology</subject><subject>Articulata</subject><subject>Biological and medical sciences</subject><subject>Cercopithecus aethiops</subject><subject>Coumarins - chemistry</subject><subject>Coumarins - isolation & purification</subject><subject>Coumarins - pharmacology</subject><subject>General pharmacology</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Inhibitory Concentration 50</subject><subject>Leishmania donovani - drug effects</subject><subject>Medical sciences</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Roots - chemistry</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Rutaceae - chemistry</subject><subject>Uganda</subject><subject>Vero Cells</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U9rFDEYBvAgFbutHvwCkkupPYy--TebPW4XW4WCoK3X4d1MAtnOJtMkI_TbN2vX1YMIgRD48STvE0LeMvjAgLOPYeQAUnP1gsyY4tC0wNURmQFrRSN0K4_JSc4bABCwUK_IMWcLraCFGem-lzSZMiVLMfTUB_rDlxTpMhQ_YsLsizd0aYr_6csjjY6uYsjFl8mGkn-dd37MPlNM1U4DFqTfYiz0EtP9a_LS4ZDtm_1-Su6uPt2uPjc3X6-_rJY3DUopSlMf0zINamHnrkUhndXQz0VdtneagTa8zgV9L6R063YOBo1xtnUCBK4RxCk5f84dU3yYbC7d1mdjhwGDjVPuFsAAFOe6yvf_lbVAKUEpvQu9eKYmxZyTdd2Y_BbTY8eg2zXfHZqv9t0-dlpvbX-Qv6uu4GwPMBscXMJgfP7j5FzW7_rLocndJk4p1N7-ceET5CWWeQ</recordid><startdate>20111028</startdate><enddate>20111028</enddate><creator>Lacroix, Damien</creator><creator>Prado, Soizic</creator><creator>Kamoga, Dennis</creator><creator>Kasenene, John</creator><creator>Bodo, Bernard</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20111028</creationdate><title>Structure and in Vitro Antiparasitic Activity of Constituents of Citropsis articulata Root Bark</title><author>Lacroix, Damien ; Prado, Soizic ; Kamoga, Dennis ; Kasenene, John ; Bodo, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a443t-506618059e7f6a34fe80d73d73edf8108c25200dd344fb670caccfe6f303aba03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alkaloids - chemistry</topic><topic>Alkaloids - isolation & purification</topic><topic>Animals</topic><topic>Antimalarials - chemistry</topic><topic>Antimalarials - isolation & purification</topic><topic>Antimalarials - pharmacology</topic><topic>Articulata</topic><topic>Biological and medical sciences</topic><topic>Cercopithecus aethiops</topic><topic>Coumarins - chemistry</topic><topic>Coumarins - isolation & purification</topic><topic>Coumarins - pharmacology</topic><topic>General pharmacology</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Inhibitory Concentration 50</topic><topic>Leishmania donovani - drug effects</topic><topic>Medical sciences</topic><topic>Parasitic Sensitivity Tests</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Roots - chemistry</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Rutaceae - chemistry</topic><topic>Uganda</topic><topic>Vero Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lacroix, Damien</creatorcontrib><creatorcontrib>Prado, Soizic</creatorcontrib><creatorcontrib>Kamoga, Dennis</creatorcontrib><creatorcontrib>Kasenene, John</creatorcontrib><creatorcontrib>Bodo, Bernard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lacroix, Damien</au><au>Prado, Soizic</au><au>Kamoga, Dennis</au><au>Kasenene, John</au><au>Bodo, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure and in Vitro Antiparasitic Activity of Constituents of Citropsis articulata Root Bark</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2011-10-28</date><risdate>2011</risdate><volume>74</volume><issue>10</issue><spage>2286</spage><epage>2289</epage><pages>2286-2289</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL.</abstract><cop>Northbrook, IL</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>21985060</pmid><doi>10.1021/np2004825</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2011-10, Vol.74 (10), p.2286-2289 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_901005228 |
| source | MEDLINE; ACS Publications |
| subjects | Alkaloids - chemistry Alkaloids - isolation & purification Animals Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Articulata Biological and medical sciences Cercopithecus aethiops Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology General pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Inhibitory Concentration 50 Leishmania donovani - drug effects Medical sciences Parasitic Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plasmodium falciparum Plasmodium falciparum - drug effects Rutaceae - chemistry Uganda Vero Cells |
| title | Structure and in Vitro Antiparasitic Activity of Constituents of Citropsis articulata Root Bark |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T22%3A01%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structure%20and%20in%20Vitro%20Antiparasitic%20Activity%20of%20Constituents%20of%20Citropsis%20articulata%20Root%20Bark&rft.jtitle=Journal%20of%20natural%20products%20(Washington,%20D.C.)&rft.au=Lacroix,%20Damien&rft.date=2011-10-28&rft.volume=74&rft.issue=10&rft.spage=2286&rft.epage=2289&rft.pages=2286-2289&rft.issn=0163-3864&rft.eissn=1520-6025&rft.coden=JNPRDF&rft_id=info:doi/10.1021/np2004825&rft_dat=%3Cproquest_cross%3E901005228%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1524405580&rft_id=info:pmid/21985060&rfr_iscdi=true |