An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis

Background & Aims The role of interleukin (IL)-5 in the pathogenesis of eosinophilic esophagitis (EoE) has been established in animal models; anti–IL-5 therapy has been reported to be effective in adults. We investigated whether IL-5 has a role in accumulation of esophageal eosinophils in childr...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-11, Vol.141 (5), p.1593-1604
Hauptverfasser:	Assa'ad, Amal H, Gupta, Sandeep K, Collins, Margaret H, Thomson, Mike, Heath, Amy T, Smith, Deborah A, Perschy, Teresa L, Jurgensen, Cynthia H, Ortega, Hector G, Aceves, Seema S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized - pharmacokinetics Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use Child Child, Preschool Clinical Trial Dose-Response Relationship, Drug Double-Blind Method Endpoint Determination Eosinophilic Esophagitis - drug therapy Eosinophilic Esophagitis - pathology Eosinophils - drug effects Eosinophils - pathology Epithelium - drug effects Epithelium - pathology Esophagus Esophagus - drug effects Esophagus - pathology Female Gastroenterology and Hepatology Histopathology Analysis Humans Interleukin-5 - antagonists & inhibitors Interleukin-5 - immunology International Cooperation Male Pediatric Treatment Outcome
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