Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

Background & Aims We previously established long-term culture conditions under which single crypts or stem cells derived from mouse small intestine expand over long periods. The expanding crypts undergo multiple crypt fission events, simultaneously generating villus-like epithelial domains that...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-11, Vol.141 (5), p.1762-1772
Hauptverfasser:	Sato, Toshiro, Stange, Daniel E, Ferrante, Marc, Vries, Robert G.J, van Es, Johan H, van den Brink, Stieneke, van Houdt, Winan J, Pronk, Apollo, van Gorp, Joost, Siersema, Peter D, Clevers, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Adenoma - pathology Adult Aged Aged, 80 and over Animals Barrett Esophagus - pathology Biopsy Cell Culture Techniques - methods Cell Proliferation - drug effects Cells, Cultured Colon - pathology Colonic Neoplasms - pathology Dysplasia Epithelium - pathology Ex Vivo Culture Technology Gastroenterology and Hepatology Hayflick Model Humans Intestine, Small - pathology Mice Mice, Inbred C57BL Middle Aged Neoplasia Niacinamide - pharmacology Organoids - pathology Signaling Wnt3A Protein - pharmacology
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