Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction

Mesenchymal stem cells （MSCs） have been extensively applied for the restoration of cardiomyocytes loss after acute myocardial infarction （AMI）. However, the optimal therapeutic efficacy of MSCs in ischemic heart diseases has been hampered by their poor survival and low differentiated rates. Therefor...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2011-11, Vol.43 (11), p.857-866
Hauptverfasser:	Cai, Anping, Zheng, Dongdan, Dong, Yugang, Qiu, Ruofeng, Huang, Yuli, Song, Yuanbin, Jiang, Zhigao, Rao, Shaoqi, Liao, Xinxue, Kuang, Jian, Dai, Gang, Mai, Weiyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Adipose Tissue - transplantation Animals Atorvastatin Calcium bcl-2-Associated X Protein - drug effects bcl-2-Associated X Protein - metabolism Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Coculture Techniques Disease Models, Animal GATA4 Transcription Factor - metabolism Heart Function Tests Heptanoic Acids - pharmacology Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - metabolism Myocardial Infarction - metabolism Myocardial Infarction - therapy Myocytes, Cardiac - metabolism Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrroles - pharmacology Rats Rats, Sprague-Dawley Troponin I - metabolism Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism Vascular Cell Adhesion Molecule-1 - drug effects Vascular Cell Adhesion Molecule-1 - metabolism 大鼠心肌肌钙蛋白I 心脏功能急性心肌梗死疗效细胞移植脂肪来源间充质干细胞
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