Determination of morphine at gold nanoparticles/Nafion® carbon paste modified sensor electrode
A novel and effective electrochemical sensor for the determination of morphine (MO) in 0.04 mol L(-1) universal buffer solution (pH 7.4) is introduced using gold nanoparticles electrodeposited on a Nafion modified carbon paste electrode. The effect of various experimental parameters including pH, sc...
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| Veröffentlicht in: | Analyst (London) 2011-11, Vol.136 (22), p.4682-4691 |
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| creator | ATTA, Nada F GALAL, Ahmed AZAB, Shereen M |
| description | A novel and effective electrochemical sensor for the determination of morphine (MO) in 0.04 mol L(-1) universal buffer solution (pH 7.4) is introduced using gold nanoparticles electrodeposited on a Nafion modified carbon paste electrode. The effect of various experimental parameters including pH, scan rate and accumulation time on the voltammetric response of MO was investigated. At the optimum conditions, the concentration of MO was determined using differential pulse voltammetry (DPV) in a linear range of 2.0 × 10(-7) to 2.6 × 10(-4) mol L(-1) with a correlation coefficient of 0.999, and a detection limit of 13.3 × 10(-10) mol L(-1), respectively. The effect of common interferences on the current response of morphine namely ascorbic acid (AA) and uric acid (UA) is studied. The modified electrode can be used for the determination of MO spiked into urine samples, and excellent recovery results were obtained. |
| doi_str_mv | 10.1039/c1an15423k |
| format | Article |
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The effect of various experimental parameters including pH, scan rate and accumulation time on the voltammetric response of MO was investigated. At the optimum conditions, the concentration of MO was determined using differential pulse voltammetry (DPV) in a linear range of 2.0 × 10(-7) to 2.6 × 10(-4) mol L(-1) with a correlation coefficient of 0.999, and a detection limit of 13.3 × 10(-10) mol L(-1), respectively. The effect of common interferences on the current response of morphine namely ascorbic acid (AA) and uric acid (UA) is studied. 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The effect of various experimental parameters including pH, scan rate and accumulation time on the voltammetric response of MO was investigated. At the optimum conditions, the concentration of MO was determined using differential pulse voltammetry (DPV) in a linear range of 2.0 × 10(-7) to 2.6 × 10(-4) mol L(-1) with a correlation coefficient of 0.999, and a detection limit of 13.3 × 10(-10) mol L(-1), respectively. The effect of common interferences on the current response of morphine namely ascorbic acid (AA) and uric acid (UA) is studied. The modified electrode can be used for the determination of MO spiked into urine samples, and excellent recovery results were obtained.</description><subject>Analytical chemistry</subject><subject>Ascorbic Acid - chemistry</subject><subject>Calibration</subject><subject>Carbon - chemistry</subject><subject>Chemistry</subject><subject>Chemistry Techniques, Analytical - instrumentation</subject><subject>Dielectric Spectroscopy</subject><subject>Electrochemical methods</subject><subject>Electrochemistry</subject><subject>Electrodes</subject><subject>Exact sciences and technology</subject><subject>Fluorocarbon Polymers - chemistry</subject><subject>General, instrumentation</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Morphine - analysis</subject><subject>Morphine - urine</subject><subject>Neurotransmitter Agents - chemistry</subject><subject>Ointments</subject><subject>Reproducibility of Results</subject><subject>Tablets - chemistry</subject><subject>Uric Acid - chemistry</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MtKxDAUBuAgio6XjQ8g3YggVE9uvSxlvILoRtclTU402iY16Sx8KR_CJ7Myo7M6HPj-f_ETckjhjAKvzzVVnkrB-PsGmVFeiFxKVm2SGQDwnBVS7JDdlN6ml4KEbbLDaFXWwNmMNJc4YuydV6MLPgs260McXp3HTI3ZS-hM5pUPg4qj0x2m8wdlJ_j9lWkV2ykxqDTiFDLOOjRZQp9CzLBDPcZgcJ9sWdUlPFjdPfJ8ffU0v83vH2_u5hf3uea0GHNlWsqgolJzYy3VZY1SWOBlq2tjZEENACs0RauFaEFBW5TIKm6Q16UEzvfIybJ3iOFjgWlsepc0dp3yGBapqQEKASDFJE-XUseQUkTbDNH1Kn42FJrfPZv1nhM-WtUu2h7NP_0bcALHK6CSVp2NymuX1k6UTNSs5j-PJX9u</recordid><startdate>20111121</startdate><enddate>20111121</enddate><creator>ATTA, Nada F</creator><creator>GALAL, Ahmed</creator><creator>AZAB, Shereen M</creator><general>Royal Society of Chemistry</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111121</creationdate><title>Determination of morphine at gold nanoparticles/Nafion® carbon paste modified sensor electrode</title><author>ATTA, Nada F ; GALAL, Ahmed ; AZAB, Shereen M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-adb120815c3dff1c79e54f037bc9dd561d0026c1efc44b0a0b67e283de3975033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analytical chemistry</topic><topic>Ascorbic Acid - chemistry</topic><topic>Calibration</topic><topic>Carbon - chemistry</topic><topic>Chemistry</topic><topic>Chemistry Techniques, Analytical - instrumentation</topic><topic>Dielectric Spectroscopy</topic><topic>Electrochemical methods</topic><topic>Electrochemistry</topic><topic>Electrodes</topic><topic>Exact sciences and technology</topic><topic>Fluorocarbon Polymers - chemistry</topic><topic>General, instrumentation</topic><topic>Gold - chemistry</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Morphine - analysis</topic><topic>Morphine - urine</topic><topic>Neurotransmitter Agents - chemistry</topic><topic>Ointments</topic><topic>Reproducibility of Results</topic><topic>Tablets - chemistry</topic><topic>Uric Acid - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ATTA, Nada F</creatorcontrib><creatorcontrib>GALAL, Ahmed</creatorcontrib><creatorcontrib>AZAB, Shereen M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ATTA, Nada F</au><au>GALAL, Ahmed</au><au>AZAB, Shereen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of morphine at gold nanoparticles/Nafion® carbon paste modified sensor electrode</atitle><jtitle>Analyst (London)</jtitle><addtitle>Analyst</addtitle><date>2011-11-21</date><risdate>2011</risdate><volume>136</volume><issue>22</issue><spage>4682</spage><epage>4691</epage><pages>4682-4691</pages><issn>0003-2654</issn><eissn>1364-5528</eissn><coden>ANALAO</coden><abstract>A novel and effective electrochemical sensor for the determination of morphine (MO) in 0.04 mol L(-1) universal buffer solution (pH 7.4) is introduced using gold nanoparticles electrodeposited on a Nafion modified carbon paste electrode. The effect of various experimental parameters including pH, scan rate and accumulation time on the voltammetric response of MO was investigated. At the optimum conditions, the concentration of MO was determined using differential pulse voltammetry (DPV) in a linear range of 2.0 × 10(-7) to 2.6 × 10(-4) mol L(-1) with a correlation coefficient of 0.999, and a detection limit of 13.3 × 10(-10) mol L(-1), respectively. The effect of common interferences on the current response of morphine namely ascorbic acid (AA) and uric acid (UA) is studied. The modified electrode can be used for the determination of MO spiked into urine samples, and excellent recovery results were obtained.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>21879032</pmid><doi>10.1039/c1an15423k</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Analytical chemistry Ascorbic Acid - chemistry Calibration Carbon - chemistry Chemistry Chemistry Techniques, Analytical - instrumentation Dielectric Spectroscopy Electrochemical methods Electrochemistry Electrodes Exact sciences and technology Fluorocarbon Polymers - chemistry General, instrumentation Gold - chemistry Humans Hydrogen-Ion Concentration Metal Nanoparticles - chemistry Morphine - analysis Morphine - urine Neurotransmitter Agents - chemistry Ointments Reproducibility of Results Tablets - chemistry Uric Acid - chemistry |
| title | Determination of morphine at gold nanoparticles/Nafion® carbon paste modified sensor electrode |
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