Microglial cell origin and phenotypes in health and disease

Key Points In the central nervous system, microglia have important roles in maintaining tissue homeostasis and responding to infection and injury. Microglia in the brain parenchyma originate from primitive macrophages in the yolk sac and form a population that is distinct from bone marrow-derived ma...

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Veröffentlicht in:	Nature reviews. Immunology 2011-11, Vol.11 (11), p.775-787
Hauptverfasser:	Glass, Christopher K, Saijo, Kaoru
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2504/342/1952 631/250/371 Biomedical and Life Sciences Biomedicine Bone marrow Brain Brain - cytology Brain - immunology Brain - metabolism Cancer Cell Lineage - immunology Central nervous system Cytokines Gene Expression Genetic aspects Health aspects Homeostasis Humans Immune response Immunology Infection Macrophages Medicine Microglia Microglia - cytology Microglia - immunology Microglia - metabolism Microglial cells Myeloid Cells - cytology Myeloid Cells - immunology Myeloid Cells - metabolism Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Nervous system Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - immunology Neurodegenerative Diseases - pathology Neurons Parenchyma Pathogens Phenotype review-article Spinal cord Spinal Cord - cytology Spinal Cord - immunology Spinal Cord - metabolism Transcription factors
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