Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats
The tea from the stem bark of Caesalpinia ferrea Martius (Leguminosae) has been popularly used in the treatment of diabetes in Brazil. To investigate the hypoglycaemic properties and to elucidate the mechanisms by which the aqueous extract of the stem bark of Caesalpinia ferrea reduces blood glucose...
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| Veröffentlicht in: | Journal of ethnopharmacology 2011-10, Vol.137 (3), p.1533-1541 |
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| creator | Vasconcelos, C.F.B. Maranhão, H.M.L. Batista, T.M. Carneiro, E.M. Ferreira, F. Costa, J. Soares, L.A.L. Sá, M.D.C. Souza, T.P. Wanderley, A.G. |
| description | The tea from the stem bark of Caesalpinia ferrea Martius (Leguminosae) has been popularly used in the treatment of diabetes in Brazil.
To investigate the hypoglycaemic properties and to elucidate the mechanisms by which the aqueous extract of the stem bark of Caesalpinia ferrea reduces blood glucose levels in streptozotocin-induced diabetic rats via the enzymatic pathways of protein kinase B (PKB/Akt), AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC).
The aqueous extract of the stem bark of Caesalpinia ferrea (300 and 450mg/kg/day), vehicle and metformin (500mg/kg/day) were administered orally to STZ-diabetic rats (n=7/group) for 4 weeks. Changes in body weight, food and water intake, fasting glucose levels and oral glucose tolerance were evaluated. Phosphorylation (P) and the expression of Akt, AMPK and ACC in the liver and skeletal muscle were determined using Western blot.
The aqueous extract of the stem bark of Caesalpinia ferrea reduced blood glucose levels and improved the metabolic state of the animals. P-Akt was increased in the liver and skeletal muscle of the treated animals, P-AMPK was reduced only in the skeletal muscle of these animals and P-ACC was reduced in both when compared with untreated rats.
The results indicate that the aqueous extract of the stem bark of Caesalpinia ferrea has hypoglycaemic properties and possibly acts to regulate glucose uptake in liver and muscles by way of Akt activation, restoring the intracellular energy balance confirmed by inhibition of AMPK activation. |
| doi_str_mv | 10.1016/j.jep.2011.08.059 |
| format | Article |
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To investigate the hypoglycaemic properties and to elucidate the mechanisms by which the aqueous extract of the stem bark of Caesalpinia ferrea reduces blood glucose levels in streptozotocin-induced diabetic rats via the enzymatic pathways of protein kinase B (PKB/Akt), AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC).
The aqueous extract of the stem bark of Caesalpinia ferrea (300 and 450mg/kg/day), vehicle and metformin (500mg/kg/day) were administered orally to STZ-diabetic rats (n=7/group) for 4 weeks. Changes in body weight, food and water intake, fasting glucose levels and oral glucose tolerance were evaluated. Phosphorylation (P) and the expression of Akt, AMPK and ACC in the liver and skeletal muscle were determined using Western blot.
The aqueous extract of the stem bark of Caesalpinia ferrea reduced blood glucose levels and improved the metabolic state of the animals. P-Akt was increased in the liver and skeletal muscle of the treated animals, P-AMPK was reduced only in the skeletal muscle of these animals and P-ACC was reduced in both when compared with untreated rats.
The results indicate that the aqueous extract of the stem bark of Caesalpinia ferrea has hypoglycaemic properties and possibly acts to regulate glucose uptake in liver and muscles by way of Akt activation, restoring the intracellular energy balance confirmed by inhibition of AMPK activation.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2011.08.059</identifier><identifier>PMID: 21911047</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acetyl-CoA carboxylase (ACC) ; Acetyl-CoA Carboxylase - metabolism ; Administration, Oral ; AMP-activated protein kinase (AMPK) ; AMP-Activated Protein Kinases - metabolism ; Animals ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Blotting, Western ; Body Weight - drug effects ; Caesalpinia - chemistry ; Caesalpinia ferrea ; Diabetes ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Drinking - drug effects ; Eating - drug effects ; Energy Metabolism - drug effects ; Glucose Tolerance Test ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - pharmacology ; Leguminosae ; Liver - drug effects ; Liver - enzymology ; Male ; Metformin - pharmacology ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - enzymology ; Phosphorylation ; Plant Bark ; Plant Extracts - administration & dosage ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plants, Medicinal ; Protein kinase B ; Proto-Oncogene Proteins c-akt - metabolism ; Rats ; Rats, Wistar ; Signal Transduction - drug effects ; Time Factors</subject><ispartof>Journal of ethnopharmacology, 2011-10, Vol.137 (3), p.1533-1541</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-820f2936eaea032f2af7e0fc9a14333aab6b6dc90b1d90252d134b1f89e4426e3</citedby><cites>FETCH-LOGICAL-c461t-820f2936eaea032f2af7e0fc9a14333aab6b6dc90b1d90252d134b1f89e4426e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2011.08.059$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21911047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasconcelos, C.F.B.</creatorcontrib><creatorcontrib>Maranhão, H.M.L.</creatorcontrib><creatorcontrib>Batista, T.M.</creatorcontrib><creatorcontrib>Carneiro, E.M.</creatorcontrib><creatorcontrib>Ferreira, F.</creatorcontrib><creatorcontrib>Costa, J.</creatorcontrib><creatorcontrib>Soares, L.A.L.</creatorcontrib><creatorcontrib>Sá, M.D.C.</creatorcontrib><creatorcontrib>Souza, T.P.</creatorcontrib><creatorcontrib>Wanderley, A.G.</creatorcontrib><title>Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The tea from the stem bark of Caesalpinia ferrea Martius (Leguminosae) has been popularly used in the treatment of diabetes in Brazil.
To investigate the hypoglycaemic properties and to elucidate the mechanisms by which the aqueous extract of the stem bark of Caesalpinia ferrea reduces blood glucose levels in streptozotocin-induced diabetic rats via the enzymatic pathways of protein kinase B (PKB/Akt), AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC).
The aqueous extract of the stem bark of Caesalpinia ferrea (300 and 450mg/kg/day), vehicle and metformin (500mg/kg/day) were administered orally to STZ-diabetic rats (n=7/group) for 4 weeks. Changes in body weight, food and water intake, fasting glucose levels and oral glucose tolerance were evaluated. Phosphorylation (P) and the expression of Akt, AMPK and ACC in the liver and skeletal muscle were determined using Western blot.
The aqueous extract of the stem bark of Caesalpinia ferrea reduced blood glucose levels and improved the metabolic state of the animals. P-Akt was increased in the liver and skeletal muscle of the treated animals, P-AMPK was reduced only in the skeletal muscle of these animals and P-ACC was reduced in both when compared with untreated rats.
The results indicate that the aqueous extract of the stem bark of Caesalpinia ferrea has hypoglycaemic properties and possibly acts to regulate glucose uptake in liver and muscles by way of Akt activation, restoring the intracellular energy balance confirmed by inhibition of AMPK activation.</description><subject>Acetyl-CoA carboxylase (ACC)</subject><subject>Acetyl-CoA Carboxylase - metabolism</subject><subject>Administration, Oral</subject><subject>AMP-activated protein kinase (AMPK)</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>Animals</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Blotting, Western</subject><subject>Body Weight - drug effects</subject><subject>Caesalpinia - chemistry</subject><subject>Caesalpinia ferrea</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Drinking - drug effects</subject><subject>Eating - drug effects</subject><subject>Energy Metabolism - drug effects</subject><subject>Glucose Tolerance Test</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - isolation & purification</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Leguminosae</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Metformin - pharmacology</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - enzymology</subject><subject>Phosphorylation</subject><subject>Plant Bark</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Protein kinase B</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Signal Transduction - drug effects</subject><subject>Time Factors</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT2P1DAQhi0E4paDH0CD3FEljO1sPkSFVgeHdIgGRGlN7Al4SexgOyeW38CPxqc9KKmmed9nNPMw9lxALUC0r471kdZaghA19DXshwdsJ_pOVt2-Uw_ZDlTXV33XiAv2JKUjAHSigcfsQopBCGi6Hft9fVrD1_lkkBZnOJrsbl0-cfSWL2Ems80Y-ULmG3qXlsTDxA9ICefVeYd8ohgJ-QeM2W2Jjxi_c_qZYwHx4HnKkdYcfoUcjPOV83YzZLl1OFKmxJ3nX1zKZUXEnJ6yRxPOiZ7dz0v2-e3Vp8N1dfPx3fvDm5vKNK3IVS9hkoNqCQlByUni1BFMZkDRKKUQx3ZsrRlgFHYAuZdWqGYUUz9Q08iW1CV7eeauMfzYKGW9uGRontFT2JIeAFo1NJ0qSXFOmhhSijTpNboF40kL0HcO9FEXB_rOgYZeFwel8-Kevo0L2X-Nv08vgdfnAJUbbx1FnYwjXx7jIpmsbXD_wf8ByuWa4A</recordid><startdate>20111011</startdate><enddate>20111011</enddate><creator>Vasconcelos, C.F.B.</creator><creator>Maranhão, H.M.L.</creator><creator>Batista, T.M.</creator><creator>Carneiro, E.M.</creator><creator>Ferreira, F.</creator><creator>Costa, J.</creator><creator>Soares, L.A.L.</creator><creator>Sá, M.D.C.</creator><creator>Souza, T.P.</creator><creator>Wanderley, A.G.</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111011</creationdate><title>Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats</title><author>Vasconcelos, C.F.B. ; Maranhão, H.M.L. ; Batista, T.M. ; Carneiro, E.M. ; Ferreira, F. ; Costa, J. ; Soares, L.A.L. ; Sá, M.D.C. ; Souza, T.P. ; Wanderley, A.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-820f2936eaea032f2af7e0fc9a14333aab6b6dc90b1d90252d134b1f89e4426e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetyl-CoA carboxylase (ACC)</topic><topic>Acetyl-CoA Carboxylase - metabolism</topic><topic>Administration, Oral</topic><topic>AMP-activated protein kinase (AMPK)</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>Animals</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Blotting, Western</topic><topic>Body Weight - drug effects</topic><topic>Caesalpinia - chemistry</topic><topic>Caesalpinia ferrea</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Drinking - drug effects</topic><topic>Eating - drug effects</topic><topic>Energy Metabolism - drug effects</topic><topic>Glucose Tolerance Test</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - isolation & purification</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Leguminosae</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Metformin - pharmacology</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - enzymology</topic><topic>Phosphorylation</topic><topic>Plant Bark</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Protein kinase B</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Signal Transduction - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasconcelos, C.F.B.</creatorcontrib><creatorcontrib>Maranhão, H.M.L.</creatorcontrib><creatorcontrib>Batista, T.M.</creatorcontrib><creatorcontrib>Carneiro, E.M.</creatorcontrib><creatorcontrib>Ferreira, F.</creatorcontrib><creatorcontrib>Costa, J.</creatorcontrib><creatorcontrib>Soares, L.A.L.</creatorcontrib><creatorcontrib>Sá, M.D.C.</creatorcontrib><creatorcontrib>Souza, T.P.</creatorcontrib><creatorcontrib>Wanderley, A.G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasconcelos, C.F.B.</au><au>Maranhão, H.M.L.</au><au>Batista, T.M.</au><au>Carneiro, E.M.</au><au>Ferreira, F.</au><au>Costa, J.</au><au>Soares, L.A.L.</au><au>Sá, M.D.C.</au><au>Souza, T.P.</au><au>Wanderley, A.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2011-10-11</date><risdate>2011</risdate><volume>137</volume><issue>3</issue><spage>1533</spage><epage>1541</epage><pages>1533-1541</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>The tea from the stem bark of Caesalpinia ferrea Martius (Leguminosae) has been popularly used in the treatment of diabetes in Brazil.
To investigate the hypoglycaemic properties and to elucidate the mechanisms by which the aqueous extract of the stem bark of Caesalpinia ferrea reduces blood glucose levels in streptozotocin-induced diabetic rats via the enzymatic pathways of protein kinase B (PKB/Akt), AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC).
The aqueous extract of the stem bark of Caesalpinia ferrea (300 and 450mg/kg/day), vehicle and metformin (500mg/kg/day) were administered orally to STZ-diabetic rats (n=7/group) for 4 weeks. Changes in body weight, food and water intake, fasting glucose levels and oral glucose tolerance were evaluated. Phosphorylation (P) and the expression of Akt, AMPK and ACC in the liver and skeletal muscle were determined using Western blot.
The aqueous extract of the stem bark of Caesalpinia ferrea reduced blood glucose levels and improved the metabolic state of the animals. P-Akt was increased in the liver and skeletal muscle of the treated animals, P-AMPK was reduced only in the skeletal muscle of these animals and P-ACC was reduced in both when compared with untreated rats.
The results indicate that the aqueous extract of the stem bark of Caesalpinia ferrea has hypoglycaemic properties and possibly acts to regulate glucose uptake in liver and muscles by way of Akt activation, restoring the intracellular energy balance confirmed by inhibition of AMPK activation.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21911047</pmid><doi>10.1016/j.jep.2011.08.059</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Acetyl-CoA carboxylase (ACC) Acetyl-CoA Carboxylase - metabolism Administration, Oral AMP-activated protein kinase (AMPK) AMP-Activated Protein Kinases - metabolism Animals Blood Glucose - drug effects Blood Glucose - metabolism Blotting, Western Body Weight - drug effects Caesalpinia - chemistry Caesalpinia ferrea Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Drinking - drug effects Eating - drug effects Energy Metabolism - drug effects Glucose Tolerance Test Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Leguminosae Liver - drug effects Liver - enzymology Male Metformin - pharmacology Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Phosphorylation Plant Bark Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal Protein kinase B Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Signal Transduction - drug effects Time Factors |
| title | Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats |
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