Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex
An algal extracellular biopolymer (over 8.5×105Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer con...
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| Veröffentlicht in: | International journal of biological macromolecules 2011-12, Vol.49 (5), p.1046-1050 |
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| container_title | International journal of biological macromolecules |
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| creator | Nosáľová, G. Capek, P. Flešková, D. Jureček, Ľ. Hindák, F. Lukavský, J. Cepák, V. Ray, B. Breierová, E. Turjan, J. |
| description | An algal extracellular biopolymer (over 8.5×105Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (∼63%), galactose (∼12%), glucuronic acid (11–12%), glucose (∼5%), rhamnose (∼4%), fucose (∼3–4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view. |
| doi_str_mv | 10.1016/j.ijbiomac.2011.08.029 |
| format | Article |
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This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (∼63%), galactose (∼12%), glucuronic acid (11–12%), glucose (∼5%), rhamnose (∼4%), fucose (∼3–4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2011.08.029</identifier><identifier>PMID: 21906620</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject><![CDATA[Administration, Inhalation ; Administration, Oral ; Airway Resistance - drug effects ; Animals ; Antitussive activity ; Antitussive Agents ; Biopolymers - administration & dosage ; Biopolymers - chemistry ; Biopolymers - isolation & purification ; Bronchial Hyperreactivity - prevention & control ; Citric Acid - adverse effects ; Cough ; Cough - chemically induced ; Cough - drug therapy ; Cough - physiopathology ; Freeze Drying ; Glucuronic Acid - chemistry ; Guinea Pigs ; Male ; Monosaccharides - chemistry ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiopathology ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plethysmography ; Proteoglycan ; Proteoglycans - administration & dosage ; Proteoglycans - chemistry ; Proteoglycans - isolation & purification ; Red alga ; Reflex - drug effects ; Reflex - physiology ; Respiratory System - drug effects ; Respiratory System - physiopathology ; Rhodella grisea ; Rhodophyta - chemistry ; Smooth muscle ; Viscosity]]></subject><ispartof>International journal of biological macromolecules, 2011-12, Vol.49 (5), p.1046-1050</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-bd2e9e1ac8ece7069a121e857d6058725618de16523c4ee3f84476879b24acfb3</citedby><cites>FETCH-LOGICAL-c367t-bd2e9e1ac8ece7069a121e857d6058725618de16523c4ee3f84476879b24acfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813011003448$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21906620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nosáľová, G.</creatorcontrib><creatorcontrib>Capek, P.</creatorcontrib><creatorcontrib>Flešková, D.</creatorcontrib><creatorcontrib>Jureček, Ľ.</creatorcontrib><creatorcontrib>Hindák, F.</creatorcontrib><creatorcontrib>Lukavský, J.</creatorcontrib><creatorcontrib>Cepák, V.</creatorcontrib><creatorcontrib>Ray, B.</creatorcontrib><creatorcontrib>Breierová, E.</creatorcontrib><creatorcontrib>Turjan, J.</creatorcontrib><title>Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>An algal extracellular biopolymer (over 8.5×105Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (∼63%), galactose (∼12%), glucuronic acid (11–12%), glucose (∼5%), rhamnose (∼4%), fucose (∼3–4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.</description><subject>Administration, Inhalation</subject><subject>Administration, Oral</subject><subject>Airway Resistance - drug effects</subject><subject>Animals</subject><subject>Antitussive activity</subject><subject>Antitussive Agents</subject><subject>Biopolymers - administration & dosage</subject><subject>Biopolymers - chemistry</subject><subject>Biopolymers - isolation & purification</subject><subject>Bronchial Hyperreactivity - prevention & control</subject><subject>Citric Acid - adverse effects</subject><subject>Cough</subject><subject>Cough - chemically induced</subject><subject>Cough - drug therapy</subject><subject>Cough - physiopathology</subject><subject>Freeze Drying</subject><subject>Glucuronic Acid - chemistry</subject><subject>Guinea Pigs</subject><subject>Male</subject><subject>Monosaccharides - chemistry</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiopathology</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plethysmography</subject><subject>Proteoglycan</subject><subject>Proteoglycans - administration & dosage</subject><subject>Proteoglycans - chemistry</subject><subject>Proteoglycans - isolation & purification</subject><subject>Red alga</subject><subject>Reflex - drug effects</subject><subject>Reflex - physiology</subject><subject>Respiratory System - drug effects</subject><subject>Respiratory System - physiopathology</subject><subject>Rhodella grisea</subject><subject>Rhodophyta - chemistry</subject><subject>Smooth muscle</subject><subject>Viscosity</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq0KVLbQv4B8KxySzjiJ49yKELRISJWqcrYce7LrVRJv4w1i_z2OFrj2NNLonY_nYewSIUdA-X2b-23rw2BsLgAxB5WDaD6xFaq6yQCgOGErwBIzhQWcsS8xblNXVqg-szOBDUgpYMXsw9j1M42WeOj4s482zJH_2QRHfW_4evKRDL9aGmG3OVgydM13U9hTWPcHa0YeRm43NHhr-v7A_ehmS46nNesNn6jr6eWCnXamj_T1rZ6zp_u7v7e_ssffPx9ubx4zW8h6n7VOUENorCJLNcjGoEBSVe0kVKoWlUTlCGUlClsSFZ0qy1om3FaUxnZtcc6-Hfem__7NFPd6SDwLx0iJSjeJv1ClgJSUx6SdQozpS72b_GCmg0bQi1-91e9-9eJXg9LJbxq8fDsxtwO5j7F3oSnw4xigBPrsadLR-kWv8xPZvXbB_-_GK30-kFo</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Nosáľová, G.</creator><creator>Capek, P.</creator><creator>Flešková, D.</creator><creator>Jureček, Ľ.</creator><creator>Hindák, F.</creator><creator>Lukavský, J.</creator><creator>Cepák, V.</creator><creator>Ray, B.</creator><creator>Breierová, E.</creator><creator>Turjan, J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex</title><author>Nosáľová, G. ; Capek, P. ; Flešková, D. ; Jureček, Ľ. ; Hindák, F. ; Lukavský, J. ; Cepák, V. ; Ray, B. ; Breierová, E. ; Turjan, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-bd2e9e1ac8ece7069a121e857d6058725618de16523c4ee3f84476879b24acfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Inhalation</topic><topic>Administration, Oral</topic><topic>Airway Resistance - drug effects</topic><topic>Animals</topic><topic>Antitussive activity</topic><topic>Antitussive Agents</topic><topic>Biopolymers - administration & dosage</topic><topic>Biopolymers - chemistry</topic><topic>Biopolymers - isolation & purification</topic><topic>Bronchial Hyperreactivity - prevention & control</topic><topic>Citric Acid - adverse effects</topic><topic>Cough</topic><topic>Cough - chemically induced</topic><topic>Cough - drug therapy</topic><topic>Cough - physiopathology</topic><topic>Freeze Drying</topic><topic>Glucuronic Acid - chemistry</topic><topic>Guinea Pigs</topic><topic>Male</topic><topic>Monosaccharides - chemistry</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiopathology</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plethysmography</topic><topic>Proteoglycan</topic><topic>Proteoglycans - administration & dosage</topic><topic>Proteoglycans - chemistry</topic><topic>Proteoglycans - isolation & purification</topic><topic>Red alga</topic><topic>Reflex - drug effects</topic><topic>Reflex - physiology</topic><topic>Respiratory System - drug effects</topic><topic>Respiratory System - physiopathology</topic><topic>Rhodella grisea</topic><topic>Rhodophyta - chemistry</topic><topic>Smooth muscle</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nosáľová, G.</creatorcontrib><creatorcontrib>Capek, P.</creatorcontrib><creatorcontrib>Flešková, D.</creatorcontrib><creatorcontrib>Jureček, Ľ.</creatorcontrib><creatorcontrib>Hindák, F.</creatorcontrib><creatorcontrib>Lukavský, J.</creatorcontrib><creatorcontrib>Cepák, V.</creatorcontrib><creatorcontrib>Ray, B.</creatorcontrib><creatorcontrib>Breierová, E.</creatorcontrib><creatorcontrib>Turjan, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nosáľová, G.</au><au>Capek, P.</au><au>Flešková, D.</au><au>Jureček, Ľ.</au><au>Hindák, F.</au><au>Lukavský, J.</au><au>Cepák, V.</au><au>Ray, B.</au><au>Breierová, E.</au><au>Turjan, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>49</volume><issue>5</issue><spage>1046</spage><epage>1050</epage><pages>1046-1050</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>An algal extracellular biopolymer (over 8.5×105Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. 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| ispartof | International journal of biological macromolecules, 2011-12, Vol.49 (5), p.1046-1050 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Inhalation Administration, Oral Airway Resistance - drug effects Animals Antitussive activity Antitussive Agents Biopolymers - administration & dosage Biopolymers - chemistry Biopolymers - isolation & purification Bronchial Hyperreactivity - prevention & control Citric Acid - adverse effects Cough Cough - chemically induced Cough - drug therapy Cough - physiopathology Freeze Drying Glucuronic Acid - chemistry Guinea Pigs Male Monosaccharides - chemistry Muscle, Smooth - drug effects Muscle, Smooth - physiopathology Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - isolation & purification Plethysmography Proteoglycan Proteoglycans - administration & dosage Proteoglycans - chemistry Proteoglycans - isolation & purification Red alga Reflex - drug effects Reflex - physiology Respiratory System - drug effects Respiratory System - physiopathology Rhodella grisea Rhodophyta - chemistry Smooth muscle Viscosity |
| title | Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex |
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