How to switch from morphine or oxycodone to methadone in cancer patients? A randomised clinical phase II trial

Abstract Aim Opioid switching is a treatment strategy in cancer patients with unacceptable pain and/or adverse effects (AEs). We investigated whether patients switched to methadone by the stop and go (SAG) strategy have lower pain intensity (PI) than the patients switched over three days (3DS), and...

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Veröffentlicht in:	European journal of cancer (1990) 2011-11, Vol.47 (16), p.2463-2470
Hauptverfasser:	Moksnes, K, Dale, O, Rosland, J.H, Paulsen, Ø, Klepstad, P, Kaasa, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Aged, 80 and over Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Cancer pain Dose-Response Relationship, Drug Drug Substitution - methods Female Hematology, Oncology and Palliative Medicine Humans Male Methadone Methadone - administration & dosage Methadone - adverse effects Middle Aged Morphine - administration & dosage Morphine - adverse effects Neoplasms - complications Opioid switch Oxycodone - administration & dosage Oxycodone - adverse effects Pain - drug therapy Pain - etiology Patient Dropouts Prospective Studies Randomised
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