OX40 and CD30 signals in CD4+ T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T-cell memory but not effector function
CD4+ effector and memory T cells play a pivotal role in the development of both normal and pathogenic immune responses. This review focuses on the molecular and cellular mechanisms that regulate their development, with particular focus on the tumor necrosis factor superfamily members OX40 (TNFRSF4)...
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| Veröffentlicht in: | Immunological reviews 2011-11, Vol.244 (1), p.134-148 |
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| container_title | Immunological reviews |
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| creator | Withers, David R. Gaspal, Fabrina M. Bekiaris, Vasileios McConnell, Fiona M. Kim, MiYeon Anderson, Graham Lane, Peter J.L. |
| description | CD4+ effector and memory T cells play a pivotal role in the development of both normal and pathogenic immune responses. This review focuses on the molecular and cellular mechanisms that regulate their development, with particular focus on the tumor necrosis factor superfamily members OX40 (TNFRSF4) and CD30 (TNFRSF8). We discuss the evidence that in mice, these molecular signaling pathways act synergistically to regulate the development of both effector and memory CD4+ T cells but that the cells that regulate memory versus effector function are distinct, effectively allowing the independent regulation of the memory and effector CD4+ T‐cell pools. |
| doi_str_mv | 10.1111/j.1600-065X.2011.01057.x |
| format | Article |
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This review focuses on the molecular and cellular mechanisms that regulate their development, with particular focus on the tumor necrosis factor superfamily members OX40 (TNFRSF4) and CD30 (TNFRSF8). 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This review focuses on the molecular and cellular mechanisms that regulate their development, with particular focus on the tumor necrosis factor superfamily members OX40 (TNFRSF4) and CD30 (TNFRSF8). We discuss the evidence that in mice, these molecular signaling pathways act synergistically to regulate the development of both effector and memory CD4+ T cells but that the cells that regulate memory versus effector function are distinct, effectively allowing the independent regulation of the memory and effector CD4+ T‐cell pools.</description><subject>Animals</subject><subject>Autoimmunity</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>CD30</subject><subject>Cell Communication</subject><subject>Gene Expression - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Immunologic Memory</subject><subject>Ki-1 Antigen - genetics</subject><subject>Ki-1 Antigen - immunology</subject><subject>Ki-1 Antigen - metabolism</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Lymph Nodes - cytology</subject><subject>Lymph Nodes - immunology</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphoid Tissue - metabolism</subject><subject>lymphoid tissue inducer cells</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>OX40</subject><subject>Receptors, OX40 - genetics</subject><subject>Receptors, OX40 - immunology</subject><subject>Receptors, OX40 - metabolism</subject><subject>Signal Transduction - immunology</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>Spleen - metabolism</subject><subject>T-Lymphocytes, Helper-Inducer - cytology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><subject>TNFSF4</subject><subject>TNFSF8</subject><subject>Tumor Necrosis Factors - genetics</subject><subject>Tumor Necrosis Factors - immunology</subject><subject>Tumor Necrosis Factors - metabolism</subject><issn>0105-2896</issn><issn>1600-065X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUd1u0zAUthCIlY1XQL7jAiXYsWPHSFygMrpJY5PQNnpnObE9XJK42InWvhWPiNN2RdxhybLP8fdzrA8AiFGO03q_yjFDKEOsXOYFwjhHGJU83zwDs-PDczCbullRCXYCXsW4QghzUtCX4KRIJE4Jm4HfN0uKoOo1nH8mCEb30Ks2Qtenmr6Dt1lj2hYaa00z-LADdqbzYQvt2DeD8_0HqKB2cXCphMG3BtoEbLfd-od3Gg4uxtEkQT02JsBJbiffKdcPabv-4R-rg3o9DrD3w1_nJ7sz8MKmCc3rw3kK7r6c384vsqubxeX801XWUMR4xoTSXBDKrOYU87pSlSh1wRubvk4NKWuGFVV16jYYGVFgWpSMCIw0sRgxcgre7nXXwf8aTRxk5-I0oeqNH6MUKIFoKaqErPbIJvgYg7FyHVynwlZiJKe45EpOqcgpFTnFJXdxyU2ivjmYjHVn9JH4lE8CfNwDHl1rtv8tLC-_fptuiZ_t-SkgsznyVfgpGSe8lN-vF5Is7unF_VLIa_IHs32yRA</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Withers, David R.</creator><creator>Gaspal, Fabrina M.</creator><creator>Bekiaris, Vasileios</creator><creator>McConnell, Fiona M.</creator><creator>Kim, MiYeon</creator><creator>Anderson, Graham</creator><creator>Lane, Peter J.L.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201111</creationdate><title>OX40 and CD30 signals in CD4+ T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T-cell memory but not effector function</title><author>Withers, David R. ; Gaspal, Fabrina M. ; Bekiaris, Vasileios ; McConnell, Fiona M. ; Kim, MiYeon ; Anderson, Graham ; Lane, Peter J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4067-69ad79346fd7417b8a895d27cf2014e35b61a4ab895c10e92142563910d3f1063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Autoimmunity</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - metabolism</topic><topic>CD30</topic><topic>Cell Communication</topic><topic>Gene Expression - immunology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Immunologic Memory</topic><topic>Ki-1 Antigen - genetics</topic><topic>Ki-1 Antigen - immunology</topic><topic>Ki-1 Antigen - metabolism</topic><topic>Killer Cells, Natural - cytology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Lymph Nodes - cytology</topic><topic>Lymph Nodes - immunology</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymphoid Tissue - cytology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Lymphoid Tissue - metabolism</topic><topic>lymphoid tissue inducer cells</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>OX40</topic><topic>Receptors, OX40 - genetics</topic><topic>Receptors, OX40 - immunology</topic><topic>Receptors, OX40 - metabolism</topic><topic>Signal Transduction - immunology</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>Spleen - metabolism</topic><topic>T-Lymphocytes, Helper-Inducer - cytology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - metabolism</topic><topic>TNFSF4</topic><topic>TNFSF8</topic><topic>Tumor Necrosis Factors - genetics</topic><topic>Tumor Necrosis Factors - immunology</topic><topic>Tumor Necrosis Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Withers, David R.</creatorcontrib><creatorcontrib>Gaspal, Fabrina M.</creatorcontrib><creatorcontrib>Bekiaris, Vasileios</creatorcontrib><creatorcontrib>McConnell, Fiona M.</creatorcontrib><creatorcontrib>Kim, MiYeon</creatorcontrib><creatorcontrib>Anderson, Graham</creatorcontrib><creatorcontrib>Lane, Peter J.L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunological reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Withers, David R.</au><au>Gaspal, Fabrina M.</au><au>Bekiaris, Vasileios</au><au>McConnell, Fiona M.</au><au>Kim, MiYeon</au><au>Anderson, Graham</au><au>Lane, Peter J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OX40 and CD30 signals in CD4+ T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T-cell memory but not effector function</atitle><jtitle>Immunological reviews</jtitle><addtitle>Immunol Rev</addtitle><date>2011-11</date><risdate>2011</risdate><volume>244</volume><issue>1</issue><spage>134</spage><epage>148</epage><pages>134-148</pages><issn>0105-2896</issn><eissn>1600-065X</eissn><abstract>CD4+ effector and memory T cells play a pivotal role in the development of both normal and pathogenic immune responses. This review focuses on the molecular and cellular mechanisms that regulate their development, with particular focus on the tumor necrosis factor superfamily members OX40 (TNFRSF4) and CD30 (TNFRSF8). We discuss the evidence that in mice, these molecular signaling pathways act synergistically to regulate the development of both effector and memory CD4+ T cells but that the cells that regulate memory versus effector function are distinct, effectively allowing the independent regulation of the memory and effector CD4+ T‐cell pools.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22017436</pmid><doi>10.1111/j.1600-065X.2011.01057.x</doi><tpages>15</tpages></addata></record> |
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| ispartof | Immunological reviews, 2011-11, Vol.244 (1), p.134-148 |
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| language | eng |
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| subjects | Animals Autoimmunity B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism CD30 Cell Communication Gene Expression - immunology Humans Immunity, Innate Immunologic Memory Ki-1 Antigen - genetics Ki-1 Antigen - immunology Ki-1 Antigen - metabolism Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymph Nodes - cytology Lymph Nodes - immunology Lymph Nodes - metabolism Lymphoid Tissue - cytology Lymphoid Tissue - immunology Lymphoid Tissue - metabolism lymphoid tissue inducer cells Mice Mice, Knockout OX40 Receptors, OX40 - genetics Receptors, OX40 - immunology Receptors, OX40 - metabolism Signal Transduction - immunology Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism TNFSF4 TNFSF8 Tumor Necrosis Factors - genetics Tumor Necrosis Factors - immunology Tumor Necrosis Factors - metabolism |
| title | OX40 and CD30 signals in CD4+ T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T-cell memory but not effector function |
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