Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds

The synthesis of several series of imidazo[2,1-a]isoindol-5-ol derivatives and the results of their evaluation against Plasmodium falciparum are presented and discussed. The effects of electron-withdrawing or-donating substituents on different parts of the molecule, as well as those produced by the...

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Veröffentlicht in:	European journal of medicinal chemistry 2011-11, Vol.46 (11), p.5379-5386
Hauptverfasser:	Olmo, Esther del, Barboza, Bianca, Chiaradia, Louise D., Moreno, Alicia, Carrero-Lérida, Juana, González-Pacanowska, Dolores, Muñoz, Victoria, López-Pérez, José L., Giménez, Alberto, Benito, Agustín, Martínez, Antonio R., Ruiz-Pérez, Luis M., San Feliciano, Arturo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - chemistry Antimalarials - pharmacology Antimalarials - therapeutic use Antimalarials - toxicity Antiparasitic agents Benzene - chemistry Biological and medical sciences Cell Line Imidazoisoindoles Imidazoles - chemistry Imidazoles - pharmacology Imidazoles - therapeutic use Imidazoles - toxicity In vitro assays In vivo assays Inhibitory Concentration 50 Isoindoles - chemical synthesis Isoindoles - chemistry Isoindoles - pharmacology Isoindoles - therapeutic use Isoindoles - toxicity Male Medical sciences Mice Mouse model Parasitemia - drug therapy Pharmacology. Drug treatments Plasmodium berghei Plasmodium berghei - drug effects Plasmodium berghei - pathogenicity Plasmodium falciparum Plasmodium falciparum - drug effects Structure–activity relationship Synthesis
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