The relationship between visfatin and HOMA-IR in hypertensive patients, and the effect of antihypertensive drugs on visfatin and HOMA-IR in hypertensive patients with insulin resistance
Abstract Objective To investigate the correlation between serum visfatin and insulin resistance (IR) in non-diabetic essential hypertensive (EH) patients with and without IR, and to evaluate the effect of antihypertensive treatment on serum visfatin and IR in these patients. Methods A total of 81 no...
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| Veröffentlicht in: | Diabetes research and clinical practice 2011-10, Vol.94 (1), p.71-76 |
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| creator | Lan, Jianjun Chen, Xiaoni Chen, Xiaoping Wang, Si Zhang, Xin Wu, Kai He, Sen Peng, Yong Jiang, Lingyun Li, Longxin Wan, Liyan |
| description | Abstract Objective To investigate the correlation between serum visfatin and insulin resistance (IR) in non-diabetic essential hypertensive (EH) patients with and without IR, and to evaluate the effect of antihypertensive treatment on serum visfatin and IR in these patients. Methods A total of 81 non-diabetic EH patients, including 54 with IR and 27 without IR, were enrolled. After two weeks wash-out, patients with IR were randomly assigned to telmisartan (group T) or amlodipine (group A) for 6 months. Blood samples were taken before and after treatment for measurement of routine biochemical parameters, visfatin and insulin resistance (measured by HOMA-IR). Results Visfatin was independently correlated with HOMA-IR ( r = 0.845, P = 0.000). After 6 months of treatment, both drugs lowered HOMA-IR, more significantly so in group T than group A ( P = 0.010). Serum visfatin levels increased in group T but decreased in group A. Conclusion Serum visfatin levels were higher in non-diabetic EH patients with IR compared with those without IR. Visfatin is independently correlated with HOMA-IR. Telmisartan lowers HOMA-IR to a greater extent than amlodipine. Interestingly, serum visfatin increased with telmisartan yet decreased with amlodipine treatment. |
| doi_str_mv | 10.1016/j.diabres.2011.05.039 |
| format | Article |
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Methods A total of 81 non-diabetic EH patients, including 54 with IR and 27 without IR, were enrolled. After two weeks wash-out, patients with IR were randomly assigned to telmisartan (group T) or amlodipine (group A) for 6 months. Blood samples were taken before and after treatment for measurement of routine biochemical parameters, visfatin and insulin resistance (measured by HOMA-IR). Results Visfatin was independently correlated with HOMA-IR ( r = 0.845, P = 0.000). After 6 months of treatment, both drugs lowered HOMA-IR, more significantly so in group T than group A ( P = 0.010). Serum visfatin levels increased in group T but decreased in group A. Conclusion Serum visfatin levels were higher in non-diabetic EH patients with IR compared with those without IR. Visfatin is independently correlated with HOMA-IR. Telmisartan lowers HOMA-IR to a greater extent than amlodipine. Interestingly, serum visfatin increased with telmisartan yet decreased with amlodipine treatment.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2011.05.039</identifier><identifier>PMID: 21742399</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Aged ; Amlodipine ; Antihypertensive Agents - therapeutic use ; Endocrinology & Metabolism ; Female ; Humans ; Hypertension - blood ; Hypertension - drug therapy ; Insulin resistance ; Insulin Resistance - physiology ; Male ; Middle Aged ; Nicotinamide Phosphoribosyltransferase - blood ; Nondiabetic essential hypertension ; Prospective Studies ; Telmisartan ; Visfatin</subject><ispartof>Diabetes research and clinical practice, 2011-10, Vol.94 (1), p.71-76</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-fad2fe8fbf8e334aafd56c031ee072dd514d6ee9e50a92c99cf3ba576c92ebb53</citedby><cites>FETCH-LOGICAL-c419t-fad2fe8fbf8e334aafd56c031ee072dd514d6ee9e50a92c99cf3ba576c92ebb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822711002956$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21742399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lan, Jianjun</creatorcontrib><creatorcontrib>Chen, Xiaoni</creatorcontrib><creatorcontrib>Chen, Xiaoping</creatorcontrib><creatorcontrib>Wang, Si</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Wu, Kai</creatorcontrib><creatorcontrib>He, Sen</creatorcontrib><creatorcontrib>Peng, Yong</creatorcontrib><creatorcontrib>Jiang, Lingyun</creatorcontrib><creatorcontrib>Li, Longxin</creatorcontrib><creatorcontrib>Wan, Liyan</creatorcontrib><title>The relationship between visfatin and HOMA-IR in hypertensive patients, and the effect of antihypertensive drugs on visfatin and HOMA-IR in hypertensive patients with insulin resistance</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract Objective To investigate the correlation between serum visfatin and insulin resistance (IR) in non-diabetic essential hypertensive (EH) patients with and without IR, and to evaluate the effect of antihypertensive treatment on serum visfatin and IR in these patients. Methods A total of 81 non-diabetic EH patients, including 54 with IR and 27 without IR, were enrolled. After two weeks wash-out, patients with IR were randomly assigned to telmisartan (group T) or amlodipine (group A) for 6 months. Blood samples were taken before and after treatment for measurement of routine biochemical parameters, visfatin and insulin resistance (measured by HOMA-IR). Results Visfatin was independently correlated with HOMA-IR ( r = 0.845, P = 0.000). After 6 months of treatment, both drugs lowered HOMA-IR, more significantly so in group T than group A ( P = 0.010). Serum visfatin levels increased in group T but decreased in group A. Conclusion Serum visfatin levels were higher in non-diabetic EH patients with IR compared with those without IR. Visfatin is independently correlated with HOMA-IR. Telmisartan lowers HOMA-IR to a greater extent than amlodipine. Interestingly, serum visfatin increased with telmisartan yet decreased with amlodipine treatment.</description><subject>Aged</subject><subject>Amlodipine</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - drug therapy</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nicotinamide Phosphoribosyltransferase - blood</subject><subject>Nondiabetic essential hypertension</subject><subject>Prospective Studies</subject><subject>Telmisartan</subject><subject>Visfatin</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVks9u1DAQxi0EotvCI4B840KC_8RJfAFVFdBKRZWgnC3HHrNeskmwna320Xi7Ot0FCS6Ik-3xb2Y03zcIvaCkpITWbzal9boLEEtGKC2JKAmXj9CKtg0rWsaax2iVufbhfoJOY9wQQmpeiafohNGmYlzKFfp5uwYcoNfJj0Nc-wl3kO4ABrzz0eXogPVg8eXNp_Pi6jPOz_V-gpBgiH4HeMoEDCm-fqBSrgXOgUl4dDmS_B-wDfO3iMf_LI3vfFrn3zj3GckD-5j0YOAZeuJ0H-H58TxDXz-8v724LK5vPl5dnF8XpqIyFU5b5qB1nWuB80prZ0VtCKcApGHWClrZGkCCIFoyI6VxvNOiqY1k0HWCn6FXh7pTGH_MEJPa-mig7_UA4xyVXFTNWtaZFAfShDHGAE5NwW912CtK1GKa2qijaWoxTRGhsmk57-Wxw9xtwf7O-uVSBt4dAMhz7jwEFU3WxoD1IYut7Oj_2eLtXxVMVtMb3X-HPcTNOIchi6ioikwR9WXZnGVxKCWESVHze25BxWU</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Lan, Jianjun</creator><creator>Chen, Xiaoni</creator><creator>Chen, Xiaoping</creator><creator>Wang, Si</creator><creator>Zhang, Xin</creator><creator>Wu, Kai</creator><creator>He, Sen</creator><creator>Peng, Yong</creator><creator>Jiang, Lingyun</creator><creator>Li, Longxin</creator><creator>Wan, Liyan</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>The relationship between visfatin and HOMA-IR in hypertensive patients, and the effect of antihypertensive drugs on visfatin and HOMA-IR in hypertensive patients with insulin resistance</title><author>Lan, Jianjun ; Chen, Xiaoni ; Chen, Xiaoping ; Wang, Si ; Zhang, Xin ; Wu, Kai ; He, Sen ; Peng, Yong ; Jiang, Lingyun ; Li, Longxin ; Wan, Liyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-fad2fe8fbf8e334aafd56c031ee072dd514d6ee9e50a92c99cf3ba576c92ebb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Amlodipine</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - drug therapy</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nicotinamide Phosphoribosyltransferase - blood</topic><topic>Nondiabetic essential hypertension</topic><topic>Prospective Studies</topic><topic>Telmisartan</topic><topic>Visfatin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lan, Jianjun</creatorcontrib><creatorcontrib>Chen, Xiaoni</creatorcontrib><creatorcontrib>Chen, Xiaoping</creatorcontrib><creatorcontrib>Wang, Si</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Wu, Kai</creatorcontrib><creatorcontrib>He, Sen</creatorcontrib><creatorcontrib>Peng, Yong</creatorcontrib><creatorcontrib>Jiang, Lingyun</creatorcontrib><creatorcontrib>Li, Longxin</creatorcontrib><creatorcontrib>Wan, Liyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lan, Jianjun</au><au>Chen, Xiaoni</au><au>Chen, Xiaoping</au><au>Wang, Si</au><au>Zhang, Xin</au><au>Wu, Kai</au><au>He, Sen</au><au>Peng, Yong</au><au>Jiang, Lingyun</au><au>Li, Longxin</au><au>Wan, Liyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between visfatin and HOMA-IR in hypertensive patients, and the effect of antihypertensive drugs on visfatin and HOMA-IR in hypertensive patients with insulin resistance</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>94</volume><issue>1</issue><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract Objective To investigate the correlation between serum visfatin and insulin resistance (IR) in non-diabetic essential hypertensive (EH) patients with and without IR, and to evaluate the effect of antihypertensive treatment on serum visfatin and IR in these patients. Methods A total of 81 non-diabetic EH patients, including 54 with IR and 27 without IR, were enrolled. After two weeks wash-out, patients with IR were randomly assigned to telmisartan (group T) or amlodipine (group A) for 6 months. Blood samples were taken before and after treatment for measurement of routine biochemical parameters, visfatin and insulin resistance (measured by HOMA-IR). Results Visfatin was independently correlated with HOMA-IR ( r = 0.845, P = 0.000). After 6 months of treatment, both drugs lowered HOMA-IR, more significantly so in group T than group A ( P = 0.010). Serum visfatin levels increased in group T but decreased in group A. Conclusion Serum visfatin levels were higher in non-diabetic EH patients with IR compared with those without IR. Visfatin is independently correlated with HOMA-IR. Telmisartan lowers HOMA-IR to a greater extent than amlodipine. Interestingly, serum visfatin increased with telmisartan yet decreased with amlodipine treatment.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21742399</pmid><doi>10.1016/j.diabres.2011.05.039</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Amlodipine Antihypertensive Agents - therapeutic use Endocrinology & Metabolism Female Humans Hypertension - blood Hypertension - drug therapy Insulin resistance Insulin Resistance - physiology Male Middle Aged Nicotinamide Phosphoribosyltransferase - blood Nondiabetic essential hypertension Prospective Studies Telmisartan Visfatin |
| title | The relationship between visfatin and HOMA-IR in hypertensive patients, and the effect of antihypertensive drugs on visfatin and HOMA-IR in hypertensive patients with insulin resistance |
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