Identification of a Potent Janus Kinase 3 Inhibitor with High Selectivity within the Janus Kinase Family

We describe a synthetic approach toward the rapid modification of phenyl-indolyl maleimides and the discovery of potent Jak3 inhibitor 1 with high selectivity within the Jak kinase family. We provide a rationale for this unprecedented selectivity based on the X-ray crystal structure of an analogue o...

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