The high incidence of JC virus infection in urothelial carcinoma tissue in Taiwan
Human polyomaviruses, JC virus (JCV) and BK virus (BKV), usually remain latent in kidney and urothelial tissue after primary infection. Infection with human polyomavirus has still not been correlated conclusively with malignancy of kidney and urothelial tissue. The present study investigated further...
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| Veröffentlicht in: | Journal of medical virology 2011-12, Vol.83 (12), p.2191-2199 |
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| creator | Shen, Cheng-Huang Wu, Jiann-Der Hsu, Cheng-Da Jou, Yeong-Chin Lin, Chang-Te Wang, Meilin Wu, Shu-Fen Chan, Michael W.Y. Chiang, Ming-Ko Fang, Chiung-Yao Chang, Deching |
| description | Human polyomaviruses, JC virus (JCV) and BK virus (BKV), usually remain latent in kidney and urothelial tissue after primary infection. Infection with human polyomavirus has still not been correlated conclusively with malignancy of kidney and urothelial tissue. The present study investigated further the possible relationship between JCV/BKV infection and urothelial carcinoma. Tissue samples were examined from 33 urothelial carcinomas and 5 renal cell carcinomas for JCV/BKV infection, using nested PCR with primers common to both JCV and BKV. The viral genotypes were further verified by endonuclease digestion and DNA sequencing following the PCR. In addition, immunohistochemistry and Western blotting were also performed to detect viral large tumor protein (LT) and the late capsid protein (VP1) in the tissue samples. The results from nested PCR showed that 90.1% (30/33) of the urothelial carcinomas samples and all of the renal cell carcinomas samples (5/5) were JCV DNA positive. Both archetypal and re‐arranged JCV genotypes were detected. On the other hand, BKV DNA was detected in only one (3%) of the urothelial carcinoma tissue samples. The immunohistochemical results showed that 30% (10/33) of urothelial carcinoma tissues was stained positive for large tumor antigen (LT). However, the structural protein VP1 was not detectable in any of the tissue samples examined. The present study demonstrated that JCV is highly prevalent in urothelial carcinoma tissue as is the expression of large tumor antigen. Therefore, the findings support the hypothesis that JCV infection is associated with urothelial carcinoma. J. Med. Virol. 83:2191–2199, 2011. © 2011 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.22240 |
| format | Article |
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Infection with human polyomavirus has still not been correlated conclusively with malignancy of kidney and urothelial tissue. The present study investigated further the possible relationship between JCV/BKV infection and urothelial carcinoma. Tissue samples were examined from 33 urothelial carcinomas and 5 renal cell carcinomas for JCV/BKV infection, using nested PCR with primers common to both JCV and BKV. The viral genotypes were further verified by endonuclease digestion and DNA sequencing following the PCR. In addition, immunohistochemistry and Western blotting were also performed to detect viral large tumor protein (LT) and the late capsid protein (VP1) in the tissue samples. The results from nested PCR showed that 90.1% (30/33) of the urothelial carcinomas samples and all of the renal cell carcinomas samples (5/5) were JCV DNA positive. Both archetypal and re‐arranged JCV genotypes were detected. On the other hand, BKV DNA was detected in only one (3%) of the urothelial carcinoma tissue samples. The immunohistochemical results showed that 30% (10/33) of urothelial carcinoma tissues was stained positive for large tumor antigen (LT). However, the structural protein VP1 was not detectable in any of the tissue samples examined. The present study demonstrated that JCV is highly prevalent in urothelial carcinoma tissue as is the expression of large tumor antigen. Therefore, the findings support the hypothesis that JCV infection is associated with urothelial carcinoma. J. Med. Virol. 83:2191–2199, 2011. © 2011 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.22240</identifier><identifier>PMID: 22012728</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens, Viral - analysis ; Biological and medical sciences ; BK virus ; Blotting, Western ; carcinogenesis ; Carcinoma - epidemiology ; Carcinoma - virology ; DNA, Viral - chemistry ; DNA, Viral - genetics ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Histocytochemistry ; human polyomavirus infection ; Human viral diseases ; Humans ; Immunohistochemistry ; Incidence ; Infectious diseases ; JC virus ; JC Virus - isolation & purification ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; nested PCR ; Polymerase Chain Reaction ; Polyomavirus ; Polyomavirus Infections - epidemiology ; Polyomavirus Infections - virology ; Sequence Analysis, DNA ; Taiwan - epidemiology ; Tumor Virus Infections - epidemiology ; Tumor Virus Infections - virology ; Urologic Neoplasms - epidemiology ; Urologic Neoplasms - virology ; Urothelium - pathology ; Urothelium - virology ; Viral diseases ; Virology</subject><ispartof>Journal of medical virology, 2011-12, Vol.83 (12), p.2191-2199</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5190-bf8930c639521826c85067c24dabd7fbfa8b137370afaa1368eaf238800fbaae3</citedby><cites>FETCH-LOGICAL-c5190-bf8930c639521826c85067c24dabd7fbfa8b137370afaa1368eaf238800fbaae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.22240$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.22240$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24694434$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22012728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Cheng-Huang</creatorcontrib><creatorcontrib>Wu, Jiann-Der</creatorcontrib><creatorcontrib>Hsu, Cheng-Da</creatorcontrib><creatorcontrib>Jou, Yeong-Chin</creatorcontrib><creatorcontrib>Lin, Chang-Te</creatorcontrib><creatorcontrib>Wang, Meilin</creatorcontrib><creatorcontrib>Wu, Shu-Fen</creatorcontrib><creatorcontrib>Chan, Michael W.Y.</creatorcontrib><creatorcontrib>Chiang, Ming-Ko</creatorcontrib><creatorcontrib>Fang, Chiung-Yao</creatorcontrib><creatorcontrib>Chang, Deching</creatorcontrib><title>The high incidence of JC virus infection in urothelial carcinoma tissue in Taiwan</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Human polyomaviruses, JC virus (JCV) and BK virus (BKV), usually remain latent in kidney and urothelial tissue after primary infection. Infection with human polyomavirus has still not been correlated conclusively with malignancy of kidney and urothelial tissue. The present study investigated further the possible relationship between JCV/BKV infection and urothelial carcinoma. Tissue samples were examined from 33 urothelial carcinomas and 5 renal cell carcinomas for JCV/BKV infection, using nested PCR with primers common to both JCV and BKV. The viral genotypes were further verified by endonuclease digestion and DNA sequencing following the PCR. In addition, immunohistochemistry and Western blotting were also performed to detect viral large tumor protein (LT) and the late capsid protein (VP1) in the tissue samples. The results from nested PCR showed that 90.1% (30/33) of the urothelial carcinomas samples and all of the renal cell carcinomas samples (5/5) were JCV DNA positive. Both archetypal and re‐arranged JCV genotypes were detected. On the other hand, BKV DNA was detected in only one (3%) of the urothelial carcinoma tissue samples. The immunohistochemical results showed that 30% (10/33) of urothelial carcinoma tissues was stained positive for large tumor antigen (LT). However, the structural protein VP1 was not detectable in any of the tissue samples examined. The present study demonstrated that JCV is highly prevalent in urothelial carcinoma tissue as is the expression of large tumor antigen. Therefore, the findings support the hypothesis that JCV infection is associated with urothelial carcinoma. J. Med. Virol. 83:2191–2199, 2011. © 2011 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>BK virus</subject><subject>Blotting, Western</subject><subject>carcinogenesis</subject><subject>Carcinoma - epidemiology</subject><subject>Carcinoma - virology</subject><subject>DNA, Viral - chemistry</subject><subject>DNA, Viral - genetics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Genotype</topic><topic>Histocytochemistry</topic><topic>human polyomavirus infection</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>JC virus</topic><topic>JC Virus - isolation & purification</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>nested PCR</topic><topic>Polymerase Chain Reaction</topic><topic>Polyomavirus</topic><topic>Polyomavirus Infections - epidemiology</topic><topic>Polyomavirus Infections - virology</topic><topic>Sequence Analysis, DNA</topic><topic>Taiwan - epidemiology</topic><topic>Tumor Virus Infections - epidemiology</topic><topic>Tumor Virus Infections - virology</topic><topic>Urologic Neoplasms - epidemiology</topic><topic>Urologic Neoplasms - virology</topic><topic>Urothelium - pathology</topic><topic>Urothelium - virology</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Cheng-Huang</creatorcontrib><creatorcontrib>Wu, Jiann-Der</creatorcontrib><creatorcontrib>Hsu, Cheng-Da</creatorcontrib><creatorcontrib>Jou, Yeong-Chin</creatorcontrib><creatorcontrib>Lin, Chang-Te</creatorcontrib><creatorcontrib>Wang, Meilin</creatorcontrib><creatorcontrib>Wu, Shu-Fen</creatorcontrib><creatorcontrib>Chan, Michael W.Y.</creatorcontrib><creatorcontrib>Chiang, Ming-Ko</creatorcontrib><creatorcontrib>Fang, Chiung-Yao</creatorcontrib><creatorcontrib>Chang, Deching</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Cheng-Huang</au><au>Wu, Jiann-Der</au><au>Hsu, Cheng-Da</au><au>Jou, Yeong-Chin</au><au>Lin, Chang-Te</au><au>Wang, Meilin</au><au>Wu, Shu-Fen</au><au>Chan, Michael W.Y.</au><au>Chiang, Ming-Ko</au><au>Fang, Chiung-Yao</au><au>Chang, Deching</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The high incidence of JC virus infection in urothelial carcinoma tissue in Taiwan</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2011-12</date><risdate>2011</risdate><volume>83</volume><issue>12</issue><spage>2191</spage><epage>2199</epage><pages>2191-2199</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>Human polyomaviruses, JC virus (JCV) and BK virus (BKV), usually remain latent in kidney and urothelial tissue after primary infection. Infection with human polyomavirus has still not been correlated conclusively with malignancy of kidney and urothelial tissue. The present study investigated further the possible relationship between JCV/BKV infection and urothelial carcinoma. Tissue samples were examined from 33 urothelial carcinomas and 5 renal cell carcinomas for JCV/BKV infection, using nested PCR with primers common to both JCV and BKV. The viral genotypes were further verified by endonuclease digestion and DNA sequencing following the PCR. In addition, immunohistochemistry and Western blotting were also performed to detect viral large tumor protein (LT) and the late capsid protein (VP1) in the tissue samples. The results from nested PCR showed that 90.1% (30/33) of the urothelial carcinomas samples and all of the renal cell carcinomas samples (5/5) were JCV DNA positive. Both archetypal and re‐arranged JCV genotypes were detected. On the other hand, BKV DNA was detected in only one (3%) of the urothelial carcinoma tissue samples. The immunohistochemical results showed that 30% (10/33) of urothelial carcinoma tissues was stained positive for large tumor antigen (LT). However, the structural protein VP1 was not detectable in any of the tissue samples examined. The present study demonstrated that JCV is highly prevalent in urothelial carcinoma tissue as is the expression of large tumor antigen. Therefore, the findings support the hypothesis that JCV infection is associated with urothelial carcinoma. J. Med. Virol. 83:2191–2199, 2011. © 2011 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22012728</pmid><doi>10.1002/jmv.22240</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antigens, Viral - analysis Biological and medical sciences BK virus Blotting, Western carcinogenesis Carcinoma - epidemiology Carcinoma - virology DNA, Viral - chemistry DNA, Viral - genetics Epidemiology Female Fundamental and applied biological sciences. Psychology Genotype Histocytochemistry human polyomavirus infection Human viral diseases Humans Immunohistochemistry Incidence Infectious diseases JC virus JC Virus - isolation & purification Male Medical sciences Microbiology Middle Aged Miscellaneous nested PCR Polymerase Chain Reaction Polyomavirus Polyomavirus Infections - epidemiology Polyomavirus Infections - virology Sequence Analysis, DNA Taiwan - epidemiology Tumor Virus Infections - epidemiology Tumor Virus Infections - virology Urologic Neoplasms - epidemiology Urologic Neoplasms - virology Urothelium - pathology Urothelium - virology Viral diseases Virology |
| title | The high incidence of JC virus infection in urothelial carcinoma tissue in Taiwan |
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