Pretreatment with an Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Enhances the Cytotoxic Effects of Amphotericin B
Taiwanofungus camphoratus, a well-known Chinese medicine used in Taiwan, possesses several pharmacological functions, including anticancer effects. In the present study, we aimed to investigate a novel anticancer effect by pretreating cancer cells with an ethanolic extract of T. camphoratus (TCEE) f...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2011-10, Vol.59 (20), p.11255-11263 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Chen, Ling-Yi Sheu, Ming-Thau Liu, Der-Zen Liao, Chuh-Kai Ho, Hsiu-O Kao, Woei-Yao Ho, Yaun-Soon Lee, Wen-Sen Su, Ching-Hua |
| description | Taiwanofungus camphoratus, a well-known Chinese medicine used in Taiwan, possesses several pharmacological functions, including anticancer effects. In the present study, we aimed to investigate a novel anticancer effect by pretreating cancer cells with an ethanolic extract of T. camphoratus (TCEE) followed by the administration of an antifungal agent amphotericin B (AmB). Both TCEE and AmB showed significant dose-dependent cytotoxicity in HT29 cells. Pretreatment with a nontoxic dose of TCEE enhanced the cytotoxicity of AmB. Furthermore, significant apoptotic cell death was found in cells treated with TCEE and AmB. A combination treatment with AmB plus TCEE resulted in a significant repression of tumor growth in HT29 xenografts. Collectively, our results indicated that combined treatment with AmB and TCEE effectively induced apoptosis and inhibited tumor growth. In the future, TCEE may serve as a potential complementary and alternative medicine to treat patients suffering from colorectal cancer. |
| doi_str_mv | 10.1021/jf2024215 |
| format | Article |
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In the present study, we aimed to investigate a novel anticancer effect by pretreating cancer cells with an ethanolic extract of T. camphoratus (TCEE) followed by the administration of an antifungal agent amphotericin B (AmB). Both TCEE and AmB showed significant dose-dependent cytotoxicity in HT29 cells. Pretreatment with a nontoxic dose of TCEE enhanced the cytotoxicity of AmB. Furthermore, significant apoptotic cell death was found in cells treated with TCEE and AmB. A combination treatment with AmB plus TCEE resulted in a significant repression of tumor growth in HT29 xenografts. Collectively, our results indicated that combined treatment with AmB and TCEE effectively induced apoptosis and inhibited tumor growth. In the future, TCEE may serve as a potential complementary and alternative medicine to treat patients suffering from colorectal cancer.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf2024215</identifier><identifier>PMID: 21899275</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>alternative medicine ; amphotericin B ; Amphotericin B - administration & dosage ; Animals ; anticarcinogenic activity ; Antifungal Agents ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - isolation & purification ; Antineoplastic Combined Chemotherapy Protocols ; Antrodia - chemistry ; apoptosis ; Apoptosis - drug effects ; Biological and medical sciences ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - pathology ; colorectal neoplasms ; cytotoxicity ; Ethanol ; Food Chemistry/Biochemistry ; Food industries ; Fundamental and applied biological sciences. Psychology ; HT29 Cells ; Humans ; Male ; medicine ; Mice ; Mice, Nude ; patients ; Taiwan ; Taiwanofungus camphoratus ; Triterpenes - administration & dosage ; Triterpenes - analysis</subject><ispartof>Journal of agricultural and food chemistry, 2011-10, Vol.59 (20), p.11255-11263</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a368t-2b7c4b4f91e5336527727ab4e1992c03fc94ca8a74e591856485d13b6de0d4403</citedby><cites>FETCH-LOGICAL-a368t-2b7c4b4f91e5336527727ab4e1992c03fc94ca8a74e591856485d13b6de0d4403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf2024215$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf2024215$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24627722$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21899275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ling-Yi</creatorcontrib><creatorcontrib>Sheu, Ming-Thau</creatorcontrib><creatorcontrib>Liu, Der-Zen</creatorcontrib><creatorcontrib>Liao, Chuh-Kai</creatorcontrib><creatorcontrib>Ho, Hsiu-O</creatorcontrib><creatorcontrib>Kao, Woei-Yao</creatorcontrib><creatorcontrib>Ho, Yaun-Soon</creatorcontrib><creatorcontrib>Lee, Wen-Sen</creatorcontrib><creatorcontrib>Su, Ching-Hua</creatorcontrib><title>Pretreatment with an Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Enhances the Cytotoxic Effects of Amphotericin B</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Taiwanofungus camphoratus, a well-known Chinese medicine used in Taiwan, possesses several pharmacological functions, including anticancer effects. In the present study, we aimed to investigate a novel anticancer effect by pretreating cancer cells with an ethanolic extract of T. camphoratus (TCEE) followed by the administration of an antifungal agent amphotericin B (AmB). Both TCEE and AmB showed significant dose-dependent cytotoxicity in HT29 cells. Pretreatment with a nontoxic dose of TCEE enhanced the cytotoxicity of AmB. Furthermore, significant apoptotic cell death was found in cells treated with TCEE and AmB. A combination treatment with AmB plus TCEE resulted in a significant repression of tumor growth in HT29 xenografts. Collectively, our results indicated that combined treatment with AmB and TCEE effectively induced apoptosis and inhibited tumor growth. In the future, TCEE may serve as a potential complementary and alternative medicine to treat patients suffering from colorectal cancer.</description><subject>alternative medicine</subject><subject>amphotericin B</subject><subject>Amphotericin B - administration & dosage</subject><subject>Animals</subject><subject>anticarcinogenic activity</subject><subject>Antifungal Agents</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Antrodia - chemistry</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - pathology</subject><subject>colorectal neoplasms</subject><subject>cytotoxicity</subject><subject>Ethanol</subject><subject>Food Chemistry/Biochemistry</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Male</subject><subject>medicine</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>patients</subject><subject>Taiwan</subject><subject>Taiwanofungus camphoratus</subject><subject>Triterpenes - administration & dosage</subject><subject>Triterpenes - analysis</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFu1DAURS0EotPCgh8AbxB0EbAdO06Ww2golSqBRLuOXhy741FiD7ajtr_AV9fRTDubrp71fHT07kXoAyXfKGH0-9Ywwjij4hVaUMFIISitX6MFyZ9FLSp6gk5j3BJCaiHJW3TCaN00TIoF-v8n6BQ0pFG7hO9s2mBweJ024PxgFV7fpwAqYW_wNdi7vDWTu50iVjDuNj5Ayu-vS5eC7y0ct3CO1y5LlI44bTRePSSf_P1sNEarFGfjcoaTDlZZh3-8Q28MDFG_P8wzdPNzfb36VVz9vrhcLa8KKKs6FayTinfcNFSLsqwEk5JJ6LimOZIipVENV1CD5Fo0NKfntehp2VW9Jj3npDxDX_beXfD_Jh1TO9qo9DCA036KbUNIxbJTZvJ8T6rgYwzatLtgRwgPLSXt3Hz73HxmPx6sUzfq_pl8qjoDnw8ARAWDCbkcG48cr-YkLHOf9pwB38JtyMzNX0YoJ4TSUjbl0QQqtls_BZfreuGkR2QnoKY</recordid><startdate>20111026</startdate><enddate>20111026</enddate><creator>Chen, Ling-Yi</creator><creator>Sheu, Ming-Thau</creator><creator>Liu, Der-Zen</creator><creator>Liao, Chuh-Kai</creator><creator>Ho, Hsiu-O</creator><creator>Kao, Woei-Yao</creator><creator>Ho, Yaun-Soon</creator><creator>Lee, Wen-Sen</creator><creator>Su, Ching-Hua</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111026</creationdate><title>Pretreatment with an Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Enhances the Cytotoxic Effects of Amphotericin B</title><author>Chen, Ling-Yi ; Sheu, Ming-Thau ; Liu, Der-Zen ; Liao, Chuh-Kai ; Ho, Hsiu-O ; Kao, Woei-Yao ; Ho, Yaun-Soon ; Lee, Wen-Sen ; Su, Ching-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a368t-2b7c4b4f91e5336527727ab4e1992c03fc94ca8a74e591856485d13b6de0d4403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alternative medicine</topic><topic>amphotericin B</topic><topic>Amphotericin B - administration & dosage</topic><topic>Animals</topic><topic>anticarcinogenic activity</topic><topic>Antifungal Agents</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Antrodia - chemistry</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - pathology</topic><topic>colorectal neoplasms</topic><topic>cytotoxicity</topic><topic>Ethanol</topic><topic>Food Chemistry/Biochemistry</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>Male</topic><topic>medicine</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>patients</topic><topic>Taiwan</topic><topic>Taiwanofungus camphoratus</topic><topic>Triterpenes - administration & dosage</topic><topic>Triterpenes - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ling-Yi</creatorcontrib><creatorcontrib>Sheu, Ming-Thau</creatorcontrib><creatorcontrib>Liu, Der-Zen</creatorcontrib><creatorcontrib>Liao, Chuh-Kai</creatorcontrib><creatorcontrib>Ho, Hsiu-O</creatorcontrib><creatorcontrib>Kao, Woei-Yao</creatorcontrib><creatorcontrib>Ho, Yaun-Soon</creatorcontrib><creatorcontrib>Lee, Wen-Sen</creatorcontrib><creatorcontrib>Su, Ching-Hua</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ling-Yi</au><au>Sheu, Ming-Thau</au><au>Liu, Der-Zen</au><au>Liao, Chuh-Kai</au><au>Ho, Hsiu-O</au><au>Kao, Woei-Yao</au><au>Ho, Yaun-Soon</au><au>Lee, Wen-Sen</au><au>Su, Ching-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretreatment with an Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Enhances the Cytotoxic Effects of Amphotericin B</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2011-10-26</date><risdate>2011</risdate><volume>59</volume><issue>20</issue><spage>11255</spage><epage>11263</epage><pages>11255-11263</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Taiwanofungus camphoratus, a well-known Chinese medicine used in Taiwan, possesses several pharmacological functions, including anticancer effects. In the present study, we aimed to investigate a novel anticancer effect by pretreating cancer cells with an ethanolic extract of T. camphoratus (TCEE) followed by the administration of an antifungal agent amphotericin B (AmB). Both TCEE and AmB showed significant dose-dependent cytotoxicity in HT29 cells. Pretreatment with a nontoxic dose of TCEE enhanced the cytotoxicity of AmB. Furthermore, significant apoptotic cell death was found in cells treated with TCEE and AmB. A combination treatment with AmB plus TCEE resulted in a significant repression of tumor growth in HT29 xenografts. Collectively, our results indicated that combined treatment with AmB and TCEE effectively induced apoptosis and inhibited tumor growth. In the future, TCEE may serve as a potential complementary and alternative medicine to treat patients suffering from colorectal cancer.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>21899275</pmid><doi>10.1021/jf2024215</doi><tpages>9</tpages></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | alternative medicine amphotericin B Amphotericin B - administration & dosage Animals anticarcinogenic activity Antifungal Agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - isolation & purification Antineoplastic Combined Chemotherapy Protocols Antrodia - chemistry apoptosis Apoptosis - drug effects Biological and medical sciences Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology colorectal neoplasms cytotoxicity Ethanol Food Chemistry/Biochemistry Food industries Fundamental and applied biological sciences. Psychology HT29 Cells Humans Male medicine Mice Mice, Nude patients Taiwan Taiwanofungus camphoratus Triterpenes - administration & dosage Triterpenes - analysis |
| title | Pretreatment with an Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Enhances the Cytotoxic Effects of Amphotericin B |
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