Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

Akt activation is common in progressive thyroid cancer. In breast cancer, Akt1 induces primary cancer growth, but is reported to inhibit metastasis in vivo in several model systems. In contrast, clinical and in vitro studies suggest a metastasis-promoting role for Akt1 in thyroid cancer. The goal of...

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Veröffentlicht in:	Oncogene 2011-10, Vol.30 (42), p.4307-4315
Hauptverfasser:	Saji, M, Narahara, K, McCarty, S K, Vasko, V V, La Perle, K M, Porter, K, Jarjoura, D, Lu, C, Cheng, S-Y, Ringel, M D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/322 692/699/67/1459/1843 Adenoma - blood supply Adenoma - enzymology Age AKT protein AKT1 protein AKT2 protein Animal models Animals Apoptosis Autopsy Biological and medical sciences Breast cancer Carcinoma - blood supply Carcinoma - enzymology Carcinoma - secondary Cell Biology Cell physiology Cell receptors Cell structures and functions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Development and progression Endocrinopathies Fundamental and applied biological sciences. Psychology Gene expression Gene Knock-In Techniques Hormone receptors Hormones Human Genetics Hyperplasia Internal Medicine Invasiveness Kinases Lung Lung Neoplasms - secondary Malignant tumors Medical sciences Medicine Medicine & Public Health Metastases Metastasis Mice Mice, Inbred C57BL Miscellaneous Molecular and cellular biology Necropsy Neovascularization, Pathologic - enzymology Oncology original-article Physiological aspects Protein kinases Proto-Oncogene Proteins c-akt - deficiency Proto-Oncogene Proteins c-akt - metabolism Rodents Thyroid cancer Thyroid hormone receptors Thyroid Neoplasms - blood supply Thyroid Neoplasms - enzymology Thyroid Neoplasms - pathology Thyroid-stimulating hormone Thyroid. Thyroid axis (diseases) Thyrotropin - blood Tumors
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