In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris
Prevention of cancer through nutritional intervention has gained significant recognition in recent years. Evidence revealed from mechanistic investigations coupled with molecular epidemiology show an inverse association of dietary flavonoids intake with cancer risk. The chemopreventive and anticarci...
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| Veröffentlicht in: | British journal of nutrition 2011-10, Vol.106 (8), p.1154-1168 |
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| creator | Mishra, Pradyumna Kumar Raghuram, Gorantla Venkata Bhargava, Arpit Ahirwar, Alok Samarth, Ravindra Upadhyaya, Ravi Jain, Subodh Kumar Pathak, Neelam |
| description | Prevention of cancer through nutritional intervention has gained significant recognition in recent years. Evidence revealed from mechanistic investigations coupled with molecular epidemiology show an inverse association of dietary flavonoids intake with cancer risk. The chemopreventive and anticarcinogenic potential of Selaginella bryopteris, a traditional Indian herb referred to as ‘Sanjeevani’ in the Ayurvedic system of medicine, was examined in the present study. Comprehensive in vitro and in vivo studies were conducted on the flavonoid-rich benzene fraction of the aqueous extract that demonstrated a significant cytoprotective activity. Biomarkers of chemoprevention such as proliferative index and status of cell-cycle regulatory proteins, antioxidant property, anti-inflammatory effect, reversal of stress-induced senescence and genoprotective effect were investigated in human and murine cell cultures. Chemopreventive potential was assessed in benzopyrene-induced lung carcinogenesis and 7,12-dimethyl benz(a)anthracene-mediated skin papillomagenesis test models. Inhibition of DNA fragmentation, unperturbed cell-cycle regulation, maintenance of intracellular antioxidant defence, anti-inflammatory activity, prevention of stress-induced senescence and genoprotective effects against methyl isocyanate carcinogenicity was observed. Medium-term anticarcinogenicity and two-stage skin papillomagenesis tests strongly substantiated our in vitro observations. Results from the present study provide evidence of anticarcinogenic and chemopreventive activities of S. bryopteris hitherto unreported and reaffirm the nutritional significance of flavonoids in cancer prevention. |
| doi_str_mv | 10.1017/S0007114511001498 |
| format | Article |
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Evidence revealed from mechanistic investigations coupled with molecular epidemiology show an inverse association of dietary flavonoids intake with cancer risk. The chemopreventive and anticarcinogenic potential of Selaginella bryopteris, a traditional Indian herb referred to as ‘Sanjeevani’ in the Ayurvedic system of medicine, was examined in the present study. Comprehensive in vitro and in vivo studies were conducted on the flavonoid-rich benzene fraction of the aqueous extract that demonstrated a significant cytoprotective activity. Biomarkers of chemoprevention such as proliferative index and status of cell-cycle regulatory proteins, antioxidant property, anti-inflammatory effect, reversal of stress-induced senescence and genoprotective effect were investigated in human and murine cell cultures. Chemopreventive potential was assessed in benzopyrene-induced lung carcinogenesis and 7,12-dimethyl benz(a)anthracene-mediated skin papillomagenesis test models. Inhibition of DNA fragmentation, unperturbed cell-cycle regulation, maintenance of intracellular antioxidant defence, anti-inflammatory activity, prevention of stress-induced senescence and genoprotective effects against methyl isocyanate carcinogenicity was observed. Medium-term anticarcinogenicity and two-stage skin papillomagenesis tests strongly substantiated our in vitro observations. Results from the present study provide evidence of anticarcinogenic and chemopreventive activities of S. bryopteris hitherto unreported and reaffirm the nutritional significance of flavonoids in cancer prevention.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114511001498</identifier><identifier>PMID: 21736819</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject><![CDATA[Animals ; Animals, Newborn ; Anthracene ; anti-inflammatory activity ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; anticarcinogenic activity ; Anticarcinogenic Agents - administration & dosage ; Anticarcinogenic Agents - isolation & purification ; Anticarcinogenic Agents - pharmacology ; antioxidant activity ; Antioxidants ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Apoptosis - drug effects ; Benzene ; Biological and medical sciences ; Biomarkers ; Cancer ; Carcinogenesis ; Carcinogenicity ; cell culture ; cell cycle ; Cell Cycle Proteins - metabolism ; Cell Line ; Cell Proliferation - drug effects ; chemoprevention ; Diet ; DNA Damage - drug effects ; DNA fragmentation ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Epidemiology ; Feeding. Feeding behavior ; Flavonoids ; Flavonoids - administration & dosage ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; Fundamental and applied biological sciences. Psychology ; Health risks ; Herbs ; Humans ; in vivo studies ; India ; Isocyanates ; medicine ; Medicine, Traditional ; methyl isocyanate ; Mice ; molecular epidemiology ; Molecular Nutrition ; Nutrition research ; nutritional intervention ; Papilloma - chemically induced ; Papilloma - prevention & control ; Plants, Medicinal - chemistry ; Prevention ; regulatory proteins ; risk ; Selaginella ; Selaginellaceae - chemistry ; senescence ; Skin Neoplasms - chemically induced ; Skin Neoplasms - prevention & control ; Vertebrates: anatomy and physiology, studies on body, several organs or systems]]></subject><ispartof>British journal of nutrition, 2011-10, Vol.106 (8), p.1154-1168</ispartof><rights>Copyright © The Authors 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-e4c3363a204ed0931c7ca86e60142ad1681bb8d72673b5c60aa00ebe46d70e1e3</citedby><cites>FETCH-LOGICAL-c425t-e4c3363a204ed0931c7ca86e60142ad1681bb8d72673b5c60aa00ebe46d70e1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114511001498/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,778,782,27911,27912,55615</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24697578$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21736819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mishra, Pradyumna Kumar</creatorcontrib><creatorcontrib>Raghuram, Gorantla Venkata</creatorcontrib><creatorcontrib>Bhargava, Arpit</creatorcontrib><creatorcontrib>Ahirwar, Alok</creatorcontrib><creatorcontrib>Samarth, Ravindra</creatorcontrib><creatorcontrib>Upadhyaya, Ravi</creatorcontrib><creatorcontrib>Jain, Subodh Kumar</creatorcontrib><creatorcontrib>Pathak, Neelam</creatorcontrib><title>In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Prevention of cancer through nutritional intervention has gained significant recognition in recent years. Evidence revealed from mechanistic investigations coupled with molecular epidemiology show an inverse association of dietary flavonoids intake with cancer risk. The chemopreventive and anticarcinogenic potential of Selaginella bryopteris, a traditional Indian herb referred to as ‘Sanjeevani’ in the Ayurvedic system of medicine, was examined in the present study. Comprehensive in vitro and in vivo studies were conducted on the flavonoid-rich benzene fraction of the aqueous extract that demonstrated a significant cytoprotective activity. Biomarkers of chemoprevention such as proliferative index and status of cell-cycle regulatory proteins, antioxidant property, anti-inflammatory effect, reversal of stress-induced senescence and genoprotective effect were investigated in human and murine cell cultures. Chemopreventive potential was assessed in benzopyrene-induced lung carcinogenesis and 7,12-dimethyl benz(a)anthracene-mediated skin papillomagenesis test models. Inhibition of DNA fragmentation, unperturbed cell-cycle regulation, maintenance of intracellular antioxidant defence, anti-inflammatory activity, prevention of stress-induced senescence and genoprotective effects against methyl isocyanate carcinogenicity was observed. Medium-term anticarcinogenicity and two-stage skin papillomagenesis tests strongly substantiated our in vitro observations. Results from the present study provide evidence of anticarcinogenic and chemopreventive activities of S. bryopteris hitherto unreported and reaffirm the nutritional significance of flavonoids in cancer prevention.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Anthracene</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>anticarcinogenic activity</subject><subject>Anticarcinogenic Agents - administration & dosage</subject><subject>Anticarcinogenic Agents - isolation & purification</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Benzene</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogenicity</subject><subject>cell culture</subject><subject>cell cycle</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>chemoprevention</subject><subject>Diet</subject><subject>DNA Damage - drug effects</subject><subject>DNA fragmentation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Flavonoids</subject><subject>Flavonoids - administration & dosage</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health risks</subject><subject>Herbs</subject><subject>Humans</subject><subject>in vivo studies</subject><subject>India</subject><subject>Isocyanates</subject><subject>medicine</subject><subject>Medicine, Traditional</subject><subject>methyl isocyanate</subject><subject>Mice</subject><subject>molecular epidemiology</subject><subject>Molecular Nutrition</subject><subject>Nutrition research</subject><subject>nutritional intervention</subject><subject>Papilloma - chemically induced</subject><subject>Papilloma - prevention & control</subject><subject>Plants, Medicinal - chemistry</subject><subject>Prevention</subject><subject>regulatory proteins</subject><subject>risk</subject><subject>Selaginella</subject><subject>Selaginellaceae - chemistry</subject><subject>senescence</subject><subject>Skin Neoplasms - chemically induced</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kd2K1DAUx4Mo7uzoA3ijQVi8qiZNm7SXsvgxsODFuNflND2dydImNWkL-1S-osnO6IIiBJKT8zv_80XIK87ec8bVhz1jTHFelJwzxou6ekI2vFBllkuZPyWb5M6S_4JchnAXzYqz-jm5yLkSsuL1hvzcWbqa2TsKtqMmGaujuMKwwGycpa6n8xGjdzYavDbWHdAa_YBrsBo91Ucc3eRxxQitSCc3pxcMKRhoP8DqrDNd5o0-0t6DflDuvRuje_bQmfQR-Z3tDFh6RN_SPQ5wMBaHAWjr7900ozfhBXnWwxDw5fnektvPn75ff81uvn3ZXX-8yXSRl3OGhRZCCshZgR2rBddKQyVRxjHl0PHYfNtWncqlEm2pJQNgDFssZKcYchRb8u6kO3n3Y8EwN6MJOhVj0S2hqRmTuWSFiOTbv8g7t_jYTYKkUoWIZ0v4CdLeheCxbyZvRvD3DWdN2mXzzy5jzOuz8NKO2P2J-L28CFydAQgahjhYq0145ApZq1IloTcnrgfXwCFOsbnd5zFJTFQKWaYexLk8GFtvugM-NvH_An8BDL7Bow</recordid><startdate>20111028</startdate><enddate>20111028</enddate><creator>Mishra, Pradyumna Kumar</creator><creator>Raghuram, Gorantla Venkata</creator><creator>Bhargava, Arpit</creator><creator>Ahirwar, Alok</creator><creator>Samarth, Ravindra</creator><creator>Upadhyaya, Ravi</creator><creator>Jain, Subodh Kumar</creator><creator>Pathak, Neelam</creator><general>Cambridge University Press</general><general>CABI Pub</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20111028</creationdate><title>In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris</title><author>Mishra, Pradyumna Kumar ; Raghuram, Gorantla Venkata ; Bhargava, Arpit ; Ahirwar, Alok ; Samarth, Ravindra ; Upadhyaya, Ravi ; Jain, Subodh Kumar ; Pathak, Neelam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-e4c3363a204ed0931c7ca86e60142ad1681bb8d72673b5c60aa00ebe46d70e1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Anthracene</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>anticarcinogenic activity</topic><topic>Anticarcinogenic Agents - administration & dosage</topic><topic>Anticarcinogenic Agents - isolation & purification</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Benzene</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogenicity</topic><topic>cell culture</topic><topic>cell cycle</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>chemoprevention</topic><topic>Diet</topic><topic>DNA Damage - drug effects</topic><topic>DNA fragmentation</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Flavonoids</topic><topic>Flavonoids - administration & dosage</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health risks</topic><topic>Herbs</topic><topic>Humans</topic><topic>in vivo studies</topic><topic>India</topic><topic>Isocyanates</topic><topic>medicine</topic><topic>Medicine, Traditional</topic><topic>methyl isocyanate</topic><topic>Mice</topic><topic>molecular epidemiology</topic><topic>Molecular Nutrition</topic><topic>Nutrition research</topic><topic>nutritional intervention</topic><topic>Papilloma - chemically induced</topic><topic>Papilloma - prevention & control</topic><topic>Plants, Medicinal - chemistry</topic><topic>Prevention</topic><topic>regulatory proteins</topic><topic>risk</topic><topic>Selaginella</topic><topic>Selaginellaceae - chemistry</topic><topic>senescence</topic><topic>Skin Neoplasms - chemically induced</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishra, Pradyumna Kumar</creatorcontrib><creatorcontrib>Raghuram, Gorantla Venkata</creatorcontrib><creatorcontrib>Bhargava, Arpit</creatorcontrib><creatorcontrib>Ahirwar, Alok</creatorcontrib><creatorcontrib>Samarth, Ravindra</creatorcontrib><creatorcontrib>Upadhyaya, Ravi</creatorcontrib><creatorcontrib>Jain, Subodh Kumar</creatorcontrib><creatorcontrib>Pathak, Neelam</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishra, Pradyumna Kumar</au><au>Raghuram, Gorantla Venkata</au><au>Bhargava, Arpit</au><au>Ahirwar, Alok</au><au>Samarth, Ravindra</au><au>Upadhyaya, Ravi</au><au>Jain, Subodh Kumar</au><au>Pathak, Neelam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2011-10-28</date><risdate>2011</risdate><volume>106</volume><issue>8</issue><spage>1154</spage><epage>1168</epage><pages>1154-1168</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Prevention of cancer through nutritional intervention has gained significant recognition in recent years. Evidence revealed from mechanistic investigations coupled with molecular epidemiology show an inverse association of dietary flavonoids intake with cancer risk. The chemopreventive and anticarcinogenic potential of Selaginella bryopteris, a traditional Indian herb referred to as ‘Sanjeevani’ in the Ayurvedic system of medicine, was examined in the present study. Comprehensive in vitro and in vivo studies were conducted on the flavonoid-rich benzene fraction of the aqueous extract that demonstrated a significant cytoprotective activity. Biomarkers of chemoprevention such as proliferative index and status of cell-cycle regulatory proteins, antioxidant property, anti-inflammatory effect, reversal of stress-induced senescence and genoprotective effect were investigated in human and murine cell cultures. Chemopreventive potential was assessed in benzopyrene-induced lung carcinogenesis and 7,12-dimethyl benz(a)anthracene-mediated skin papillomagenesis test models. Inhibition of DNA fragmentation, unperturbed cell-cycle regulation, maintenance of intracellular antioxidant defence, anti-inflammatory activity, prevention of stress-induced senescence and genoprotective effects against methyl isocyanate carcinogenicity was observed. Medium-term anticarcinogenicity and two-stage skin papillomagenesis tests strongly substantiated our in vitro observations. Results from the present study provide evidence of anticarcinogenic and chemopreventive activities of S. bryopteris hitherto unreported and reaffirm the nutritional significance of flavonoids in cancer prevention.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>21736819</pmid><doi>10.1017/S0007114511001498</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2011-10, Vol.106 (8), p.1154-1168 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_900626043 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cambridge Journals - CAUL Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Animals, Newborn Anthracene anti-inflammatory activity Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology anticarcinogenic activity Anticarcinogenic Agents - administration & dosage Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - pharmacology antioxidant activity Antioxidants Antioxidants - isolation & purification Antioxidants - pharmacology Apoptosis - drug effects Benzene Biological and medical sciences Biomarkers Cancer Carcinogenesis Carcinogenicity cell culture cell cycle Cell Cycle Proteins - metabolism Cell Line Cell Proliferation - drug effects chemoprevention Diet DNA Damage - drug effects DNA fragmentation Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Epidemiology Feeding. Feeding behavior Flavonoids Flavonoids - administration & dosage Flavonoids - isolation & purification Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Health risks Herbs Humans in vivo studies India Isocyanates medicine Medicine, Traditional methyl isocyanate Mice molecular epidemiology Molecular Nutrition Nutrition research nutritional intervention Papilloma - chemically induced Papilloma - prevention & control Plants, Medicinal - chemistry Prevention regulatory proteins risk Selaginella Selaginellaceae - chemistry senescence Skin Neoplasms - chemically induced Skin Neoplasms - prevention & control Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T15%3A37%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vitro%20and%20in%20vivo%20evaluation%20of%20the%20anticarcinogenic%20and%20cancer%20chemopreventive%20potential%20of%20a%20flavonoid-rich%20fraction%20from%20a%20traditional%20Indian%20herb%20Selaginella%20bryopteris&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Mishra,%20Pradyumna%20Kumar&rft.date=2011-10-28&rft.volume=106&rft.issue=8&rft.spage=1154&rft.epage=1168&rft.pages=1154-1168&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114511001498&rft_dat=%3Cproquest_cross%3E2523487891%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=906774374&rft_id=info:pmid/21736819&rft_cupid=10_1017_S0007114511001498&rfr_iscdi=true |