Measles incidence rate and a phylogenetic study of contemporary genotype H1 measles strains in China: is an improved measles vaccine needed?
The incidence of measles in China has increased over the last decade. To evaluate the genetic variation of measles strains, 16 measles wild-type virus strains were isolated from 14 vaccinated cases and 2 nonvaccinated cases in Jilin Province during 2005–2006, and their nucleoprotein (N) and hemagglu...
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Veröffentlicht in: | Virus genes 2011-12, Vol.43 (3), p.319-326 |
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description | The incidence of measles in China has increased over the last decade. To evaluate the genetic variation of measles strains, 16 measles wild-type virus strains were isolated from 14 vaccinated cases and 2 nonvaccinated cases in Jilin Province during 2005–2006, and their nucleoprotein (N) and hemagglutinin (H) genes were amplified by RT-PCR. The amplified products were sequenced and compared with the Edmonston virus and the existing vaccine strains (Changchun-47 and Shanghai-191). The results showed that the variation rate between the vaccine and wild-type strains was 9.8–12.0% in the N gene and 5.9–6.9% in the H gene, respectively. In addition, cross-neutralization assays revealed that although sera obtained from infants following primary vaccination effectively neutralized vaccine strains, the capacity in neutralizing H1 wild-type measles virus isolates was decreased fourfold. Antigenic ratios testing revealed that the antigenic relatedness between wild-type measles viruses and existing vaccine strains was notably low. These data suggest that the increased incidence of measles in Jilin Province may be attributed to the antigenic drift between wild-type and vaccine strains. Our findings strengthen the recommendation of supplemental immunization with existing vaccines and also strongly suggest a need for developing new vaccines to better control measles virus outbreaks. |
doi_str_mv | 10.1007/s11262-011-0638-0 |
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To evaluate the genetic variation of measles strains, 16 measles wild-type virus strains were isolated from 14 vaccinated cases and 2 nonvaccinated cases in Jilin Province during 2005–2006, and their nucleoprotein (N) and hemagglutinin (H) genes were amplified by RT-PCR. The amplified products were sequenced and compared with the Edmonston virus and the existing vaccine strains (Changchun-47 and Shanghai-191). The results showed that the variation rate between the vaccine and wild-type strains was 9.8–12.0% in the N gene and 5.9–6.9% in the H gene, respectively. In addition, cross-neutralization assays revealed that although sera obtained from infants following primary vaccination effectively neutralized vaccine strains, the capacity in neutralizing H1 wild-type measles virus isolates was decreased fourfold. Antigenic ratios testing revealed that the antigenic relatedness between wild-type measles viruses and existing vaccine strains was notably low. These data suggest that the increased incidence of measles in Jilin Province may be attributed to the antigenic drift between wild-type and vaccine strains. Our findings strengthen the recommendation of supplemental immunization with existing vaccines and also strongly suggest a need for developing new vaccines to better control measles virus outbreaks.</description><identifier>ISSN: 0920-8569</identifier><identifier>EISSN: 1572-994X</identifier><identifier>DOI: 10.1007/s11262-011-0638-0</identifier><identifier>PMID: 21701857</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Adult ; Biomedical and Life Sciences ; Biomedicine ; Child ; Child, Preschool ; China - epidemiology ; Female ; Genotype ; Humans ; Incidence ; Infant ; Male ; Measles - epidemiology ; Measles - prevention & control ; Measles - virology ; Measles Vaccine - genetics ; Measles Vaccine - immunology ; Measles virus ; Measles virus - classification ; Measles virus - genetics ; Measles virus - immunology ; Measles virus - isolation & purification ; Medical Microbiology ; Molecular Sequence Data ; Phylogeny ; Plant Sciences ; Virology ; Young Adult</subject><ispartof>Virus genes, 2011-12, Vol.43 (3), p.319-326</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-67a7bec13111f744ff18ee9a69b6dc580349b4844d7dfc5eff154637b38672bd3</citedby><cites>FETCH-LOGICAL-c511t-67a7bec13111f744ff18ee9a69b6dc580349b4844d7dfc5eff154637b38672bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11262-011-0638-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11262-011-0638-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21701857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Jingwei</creatorcontrib><creatorcontrib>Zheng, Jingtong</creatorcontrib><creatorcontrib>Huang, Honglan</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><creatorcontrib>Bian, Jiang</creatorcontrib><creatorcontrib>Xu, Deqi</creatorcontrib><creatorcontrib>Li, Fan</creatorcontrib><title>Measles incidence rate and a phylogenetic study of contemporary genotype H1 measles strains in China: is an improved measles vaccine needed?</title><title>Virus genes</title><addtitle>Virus Genes</addtitle><addtitle>Virus Genes</addtitle><description>The incidence of measles in China has increased over the last decade. To evaluate the genetic variation of measles strains, 16 measles wild-type virus strains were isolated from 14 vaccinated cases and 2 nonvaccinated cases in Jilin Province during 2005–2006, and their nucleoprotein (N) and hemagglutinin (H) genes were amplified by RT-PCR. The amplified products were sequenced and compared with the Edmonston virus and the existing vaccine strains (Changchun-47 and Shanghai-191). The results showed that the variation rate between the vaccine and wild-type strains was 9.8–12.0% in the N gene and 5.9–6.9% in the H gene, respectively. In addition, cross-neutralization assays revealed that although sera obtained from infants following primary vaccination effectively neutralized vaccine strains, the capacity in neutralizing H1 wild-type measles virus isolates was decreased fourfold. Antigenic ratios testing revealed that the antigenic relatedness between wild-type measles viruses and existing vaccine strains was notably low. These data suggest that the increased incidence of measles in Jilin Province may be attributed to the antigenic drift between wild-type and vaccine strains. Our findings strengthen the recommendation of supplemental immunization with existing vaccines and also strongly suggest a need for developing new vaccines to better control measles virus outbreaks.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Male</subject><subject>Measles - epidemiology</subject><subject>Measles - prevention & control</subject><subject>Measles - virology</subject><subject>Measles Vaccine - genetics</subject><subject>Measles Vaccine - immunology</subject><subject>Measles virus</subject><subject>Measles virus - classification</subject><subject>Measles virus - genetics</subject><subject>Measles virus - immunology</subject><subject>Measles virus - 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epidemiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Male</topic><topic>Measles - epidemiology</topic><topic>Measles - prevention & control</topic><topic>Measles - virology</topic><topic>Measles Vaccine - genetics</topic><topic>Measles Vaccine - immunology</topic><topic>Measles virus</topic><topic>Measles virus - classification</topic><topic>Measles virus - genetics</topic><topic>Measles virus - immunology</topic><topic>Measles virus - isolation & purification</topic><topic>Medical Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>Plant Sciences</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Jingwei</creatorcontrib><creatorcontrib>Zheng, Jingtong</creatorcontrib><creatorcontrib>Huang, Honglan</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><creatorcontrib>Bian, Jiang</creatorcontrib><creatorcontrib>Xu, Deqi</creatorcontrib><creatorcontrib>Li, Fan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virus genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Jingwei</au><au>Zheng, Jingtong</au><au>Huang, Honglan</au><au>Hu, Yu</au><au>Bian, Jiang</au><au>Xu, Deqi</au><au>Li, Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measles incidence rate and a phylogenetic study of contemporary genotype H1 measles strains in China: is an improved measles vaccine needed?</atitle><jtitle>Virus genes</jtitle><stitle>Virus Genes</stitle><addtitle>Virus Genes</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>43</volume><issue>3</issue><spage>319</spage><epage>326</epage><pages>319-326</pages><issn>0920-8569</issn><eissn>1572-994X</eissn><abstract>The incidence of measles in China has increased over the last decade. To evaluate the genetic variation of measles strains, 16 measles wild-type virus strains were isolated from 14 vaccinated cases and 2 nonvaccinated cases in Jilin Province during 2005–2006, and their nucleoprotein (N) and hemagglutinin (H) genes were amplified by RT-PCR. The amplified products were sequenced and compared with the Edmonston virus and the existing vaccine strains (Changchun-47 and Shanghai-191). The results showed that the variation rate between the vaccine and wild-type strains was 9.8–12.0% in the N gene and 5.9–6.9% in the H gene, respectively. In addition, cross-neutralization assays revealed that although sera obtained from infants following primary vaccination effectively neutralized vaccine strains, the capacity in neutralizing H1 wild-type measles virus isolates was decreased fourfold. Antigenic ratios testing revealed that the antigenic relatedness between wild-type measles viruses and existing vaccine strains was notably low. These data suggest that the increased incidence of measles in Jilin Province may be attributed to the antigenic drift between wild-type and vaccine strains. Our findings strengthen the recommendation of supplemental immunization with existing vaccines and also strongly suggest a need for developing new vaccines to better control measles virus outbreaks.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>21701857</pmid><doi>10.1007/s11262-011-0638-0</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Biomedical and Life Sciences Biomedicine Child Child, Preschool China - epidemiology Female Genotype Humans Incidence Infant Male Measles - epidemiology Measles - prevention & control Measles - virology Measles Vaccine - genetics Measles Vaccine - immunology Measles virus Measles virus - classification Measles virus - genetics Measles virus - immunology Measles virus - isolation & purification Medical Microbiology Molecular Sequence Data Phylogeny Plant Sciences Virology Young Adult |
title | Measles incidence rate and a phylogenetic study of contemporary genotype H1 measles strains in China: is an improved measles vaccine needed? |
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