Stromal Cell-Derived Factor-1 Signaling via the CXCR4-TCR Heterodimer Requires Phospholipase C- beta 3 and Phospholipase C- gamma 1 for Distinct Cellular Responses

The CXCR4 chemokine receptor is a G protein-coupled receptor that signals in T lymphocytes by forming a heterodimer with the TCR. CXCR4 and TCR functions are consequently highly cross regulated, affecting T cell immune activation, cytokine secretion, and T cell migration. The CXCR4-TCR heterodimer s...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-08, Vol.187 (3), p.1440-1447
Hauptverfasser:	Kremer, Kimberly N, Clift, Ian C, Miamen, Alexander G, Bamidele, Adebowale O, Qian, Nan-Xin, Humphreys, Troy D, Hedin, Karen E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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