Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit
Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-s...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2002-10, Vol.21 (10), p.751-754 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | JOHNSON, A. P TYSALL, L STOCKDALE, M. W WOODFORD, N KAUFMANN, M. E WARNER, M LIVERMORE, D. M ASBOTH, F ALLERBERGER, F. J |
| description | Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect. |
| doi_str_mv | 10.1007/s10096-002-0807-0 |
| format | Article |
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P ; TYSALL, L ; STOCKDALE, M. W ; WOODFORD, N ; KAUFMANN, M. E ; WARNER, M ; LIVERMORE, D. M ; ASBOTH, F ; ALLERBERGER, F. J</creator><creatorcontrib>JOHNSON, A. P ; TYSALL, L ; STOCKDALE, M. W ; WOODFORD, N ; KAUFMANN, M. E ; WARNER, M ; LIVERMORE, D. M ; ASBOTH, F ; ALLERBERGER, F. J</creatorcontrib><description>Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-002-0807-0</identifier><identifier>PMID: 12415476</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acetamides - pharmacology ; Aged ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotic resistance ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Austria ; Base Sequence ; Biological and medical sciences ; Cross Infection - diagnosis ; Cross Infection - microbiology ; DNA, Bacterial ; Drug Resistance, Microbial ; Enterococcus faecalis ; Enterococcus faecalis - drug effects ; Enterococcus faecalis - isolation & purification ; Enterococcus faecium ; Enterococcus faecium - drug effects ; Enterococcus faecium - isolation & purification ; Gram-Positive Bacterial Infections - diagnosis ; Humans ; Intensive Care Units ; Linezolid ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Sequence Data ; Oxazolidinones - pharmacology ; Pharmacology. 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P</creatorcontrib><creatorcontrib>TYSALL, L</creatorcontrib><creatorcontrib>STOCKDALE, M. W</creatorcontrib><creatorcontrib>WOODFORD, N</creatorcontrib><creatorcontrib>KAUFMANN, M. E</creatorcontrib><creatorcontrib>WARNER, M</creatorcontrib><creatorcontrib>LIVERMORE, D. M</creatorcontrib><creatorcontrib>ASBOTH, F</creatorcontrib><creatorcontrib>ALLERBERGER, F. J</creatorcontrib><title>Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect.</description><subject>Acetamides - pharmacology</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotic resistance</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Austria</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cross Infection - diagnosis</subject><subject>Cross Infection - microbiology</subject><subject>DNA, Bacterial</subject><subject>Drug Resistance, Microbial</subject><subject>Enterococcus faecalis</subject><subject>Enterococcus faecalis - drug effects</subject><subject>Enterococcus faecalis - isolation & purification</subject><subject>Enterococcus faecium</subject><subject>Enterococcus faecium - drug effects</subject><subject>Enterococcus faecium - isolation & purification</subject><subject>Gram-Positive Bacterial Infections - diagnosis</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Linezolid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Oxazolidinones - pharmacology</subject><subject>Pharmacology. 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P ; TYSALL, L ; STOCKDALE, M. W ; WOODFORD, N ; KAUFMANN, M. E ; WARNER, M ; LIVERMORE, D. M ; ASBOTH, F ; ALLERBERGER, F. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-190b56e9c2ce2f9c268e06022544e3e735ff83a29b0e4dfc41b01db1c1353bf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetamides - pharmacology</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotic resistance</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Austria</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cross Infection - diagnosis</topic><topic>Cross Infection - microbiology</topic><topic>DNA, Bacterial</topic><topic>Drug Resistance, Microbial</topic><topic>Enterococcus faecalis</topic><topic>Enterococcus faecalis - drug effects</topic><topic>Enterococcus faecalis - isolation & purification</topic><topic>Enterococcus faecium</topic><topic>Enterococcus faecium - drug effects</topic><topic>Enterococcus faecium - isolation & purification</topic><topic>Gram-Positive Bacterial Infections - diagnosis</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Linezolid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Oxazolidinones - pharmacology</topic><topic>Pharmacology. 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P</au><au>TYSALL, L</au><au>STOCKDALE, M. W</au><au>WOODFORD, N</au><au>KAUFMANN, M. E</au><au>WARNER, M</au><au>LIVERMORE, D. M</au><au>ASBOTH, F</au><au>ALLERBERGER, F. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>21</volume><issue>10</issue><spage>751</spage><epage>754</epage><pages>751-754</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12415476</pmid><doi>10.1007/s10096-002-0807-0</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2002-10, Vol.21 (10), p.751-754 |
| issn | 0934-9723 1435-4373 |
| language | eng |
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| subjects | Acetamides - pharmacology Aged Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotic resistance Antibiotics. Antiinfectious agents. Antiparasitic agents Austria Base Sequence Biological and medical sciences Cross Infection - diagnosis Cross Infection - microbiology DNA, Bacterial Drug Resistance, Microbial Enterococcus faecalis Enterococcus faecalis - drug effects Enterococcus faecalis - isolation & purification Enterococcus faecium Enterococcus faecium - drug effects Enterococcus faecium - isolation & purification Gram-Positive Bacterial Infections - diagnosis Humans Intensive Care Units Linezolid Male Medical sciences Microbial Sensitivity Tests Middle Aged Molecular Sequence Data Oxazolidinones - pharmacology Pharmacology. Drug treatments Polymerase Chain Reaction Sensitivity and Specificity |
| title | Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit |
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