Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

Combination regimens that include artemisinin derivatives are recommended as first line antimalarials in most countries where malaria is endemic. However, the mechanism of action of artemisinin is not fully understood and the usefulness of this drug class is threatened by reports of decreased parasi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-07, Vol.108 (28), p.11405-11410
Hauptverfasser:	Klonis, Nectarios, Crespo-Ortiz, Maria P, Bottova, Iveta, Abu-Bakar, Nurhidanatasha, Kenny, Shannon, Rosenthal, Philip J, Tilley, Leann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials Antimalarials - pharmacology artemisinin Artemisinins Artemisinins - pharmacology Bacteria Biological Sciences Biological Transport, Active Cysteine Endopeptidases - deficiency Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism cysteine proteinase inhibitors cysteine proteinases Cytometry cytoplasm digestion Drug resistance drug therapy Endocytosis - drug effects Enzyme kinetics Erythrocytes - parasitology Gene Deletion Genes, Protozoan half life Hemoglobin Hemoglobins Hemoglobins - metabolism Host-Parasite Interactions - drug effects Humans Malaria Malaria, Falciparum - blood Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology mechanism of action new drugs Oxidative stress Parasitemia Parasitemia - blood Parasitemia - drug therapy Parasitemia - parasitology Parasites Parasitism Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Plasmodium falciparum - metabolism Trophozoites
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