Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells

► In drug development assays for the early detection of genotoxicity are needed. ► Two high content screening (HCS) micronucleus assays were developed and validated. ► Both HCS assays in HepG2 cells and CHO-k1 cells were able to detect genotoxic potential. ► The assays gave a low number of false-pos...

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Veröffentlicht in:	Mutation research 2011-09, Vol.724 (1-2), p.7-21
Hauptverfasser:	Westerink, Walter M.A., Schirris, Tom J.J., Horbach, G. Jean, Schoonen, Willem G.E.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneugens Animals Automated in vitro micronucleus assay Biological and medical sciences Biotransformation Cells CHO Cells CHO-k1 Cricetinae Cricetulus DNA repair Enzymes Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotoxicity Hep G2 Cells HepG2 High throughput screening Humans Image Processing, Computer-Assisted Medical sciences Medical screening Micronucleus Tests - methods Rodents Sensitivity and Specificity Toxicology
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