Genetic Associations Between Fibrinogen and Cognitive Performance in Three Scottish Cohorts

There is increasing evidence to suggest that elevated plasma levels of fibrinogen are associated with late-life cognitive performance. This study tested the association of single nucleotide polymorphisms in the fibrinogen α ( FGA ) and β ( FGB ) genes with cognitive performance. Data were analysed f...

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Veröffentlicht in:	Behavior genetics 2011-09, Vol.41 (5), p.691-699
Hauptverfasser:	Marioni, Riccardo E., Deary, Ian J., Murray, Gordon D., Lowe, Gordon D. O., Strachan, Mark W. J., Luciano, Michelle, Houlihan, Lorna M., Gow, Alan J., Harris, Sarah E., Rumley, Ann, Stewart, Marlene C., Fowkes, F. Gerry R., Price, Jackie F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Aspirin Aspirin - pharmacology Asymptomatic Atherosclerosis Atherosclerosis - genetics Behavioral Science and Psychology Cardiovascular disease Clinical Psychology Cognition & reasoning Cognition - physiology Cognition Disorders - genetics Cognition Disorders - pathology Cognitive abilities Cognitive performance Cohort Studies Community living Cross-Sectional Studies Diabetes Diabetes Complications - genetics Diabetes Mellitus, Type 2 - genetics Elderly people Epidemiology Female Fibrinogen Fibrinogen - genetics Genes Genotype Health Psychology Humans Male Middle Aged Original Research Plasma Polymorphism, Single Nucleotide Psychology Public Health Scotland
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Zusammenfassung:	There is increasing evidence to suggest that elevated plasma levels of fibrinogen are associated with late-life cognitive performance. This study tested the association of single nucleotide polymorphisms in the fibrinogen α ( FGA ) and β ( FGB ) genes with cognitive performance. Data were analysed from three community-dwelling populations of older persons (>50 years) in central Scotland: the Aspirin for Asymptomatic Atherosclerosis (AAA) Trial ( n = 2,091), the Edinburgh Type 2 Diabetes Study (ET2DS, n = 1,066), and the Lothian Birth Cohort 1936 (LBC1936, n = 1,091). Cognition was assessed using a battery of five, seven, and four psychometric tests, respectively. This information was used to derive a general cognitive factor. Weakly significant associations were found between the rs4220 ( FGB ), and rs2227412 ( FGB ) SNPs and a single test of cognitive performance in the AAA Trial ( p
ISSN:	0001-8244 1573-3297
DOI:	10.1007/s10519-011-9449-2