Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO2-PCBs

► We investigated the effects of NDL-PCBs and their metabolites on aromatase activity and glucocorticoid receptor. ► Most NDL-PCBs and MeSO2-PCBs had no effect or were mild aromatase activity inhibitors and (anti-) glucocorticoids. ► The tested OH-PCBs were stronger aromatase activity inhibitors and...

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Veröffentlicht in:	Toxicology letters 2011-10, Vol.206 (2), p.158-165
Hauptverfasser:	Antunes-Fernandes, Elsa C., Bovee, Toine F.H., Daamen, Frieda E.J., Helsdingen, Richard J., van den Berg, Martin, van Duursen, Majorie B.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatase - biosynthesis Aromatase - chemistry Aromatase activity Aromatase Inhibitors - chemistry Aromatase Inhibitors - metabolism Aromatase Inhibitors - toxicity Biological and medical sciences Cell Line Cell Survival - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Endocrine Disruptors - chemistry Endocrine Disruptors - metabolism Endocrine Disruptors - toxicity Enzyme Induction - drug effects Female Genes, Reporter - drug effects Glucocorticoid receptor Human risk assessment Humans Hydroxy-metabolite Hydroxylation Medical sciences Mesylates - chemistry Mesylates - toxicity Methylsulfonyl-metabolite Microsomes - enzymology Non-dioxin-like PCBs Osmolar Concentration Placenta - enzymology Polychlorinated Biphenyls - chemistry Polychlorinated Biphenyls - metabolism Polychlorinated Biphenyls - toxicity Pregnancy Pregnancy Proteins - antagonists & inhibitors Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Recombinant Fusion Proteins - agonists Recombinant Fusion Proteins - antagonists & inhibitors Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Response Elements - drug effects Risk Assessment - methods Toxicology Various organic compounds
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