C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice

► Enhancement of functional recovery by inhibiting JNK after SCI. ► Cell death signal JNK induces axonal degeneration. ► Our data suggest importance of axonal dieback in the pathophysiology of CNS. C-Jun N-terminal kinase (JNK) mediates neuronal death in response to stress and injury in the CNS and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience research 2011-11, Vol.71 (3), p.266-277
Hauptverfasser:	Yoshimura, Kazuhiro, Ueno, Masaki, Lee, Sachiko, Nakamura, Yuka, Sato, Akinobu, Yoshimura, Koichi, Kishima, Haruhiko, Yoshimine, Toshiki, Yamashita, Toshihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracenes - administration & dosage Axon degeneration Disease Models, Animal Female JNK Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinase 10 - antagonists & inhibitors Mitogen-Activated Protein Kinase 10 - deficiency Mitogen-Activated Protein Kinase 10 - genetics Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - deficiency Mitogen-Activated Protein Kinase 8 - physiology Nerve Regeneration - drug effects Nerve Regeneration - genetics Paralysis - enzymology Paralysis - genetics Paralysis - physiopathology Recovery of Function - drug effects Recovery of Function - genetics Spinal Cord Injuries - enzymology Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Spinal cord injury Wallerian Degeneration - enzymology Wallerian Degeneration - pathology Wallerian Degeneration - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!