Abdominal Obesity and Age-related Macular Degeneration
Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, ea...
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| Veröffentlicht in: | American journal of epidemiology 2011-06, Vol.173 (11), p.1246-1255 |
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| creator | ADAMS, Madeleine K. M SIMPSON, Julie A KHIN ZAW AUNG MAKEYEVA, Galina A GILES, Graham G ENGLISH, Dallas R HOPPER, John GUYMER, Robyn H BAIRD, Paul N ROBMAN, Liubov D |
| description | Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, each increase of 0.1 in waist/hip ratio (~1 standard deviation) was associated with a 13% increase in the odds of early AMD (odds ratio = 1.13, 95% confidence interval: 1.01, 1.26; P = 0.03) and a 75% increase in the odds of late AMD (odds ratio = 1.75, 95% confidence interval: 1.11, 2.76; P = 0.02). No other adiposity measure was associated with early AMD for men. Smoking status modified the relation between waist/hip ratio and early AMD (P = 0.05), with no association for former smokers. For women, there were inverse associations with early AMD for all adiposity measures (odds ratios = 0.89-0.93; P = 0.002-0.02), but no associations were observed for late AMD. This study confirms abdominal obesity as an AMD risk factor for men despite a survivorship effect from competing risks in morbidity and mortality. The inverse associations for women may reflect weaker true positive associations with AMD that are insufficient to overcome the survivorship effect. New data are provided on complex interactions between environmental exposures and AMD risk. |
| doi_str_mv | 10.1093/aje/kwr005 |
| format | Article |
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M ; SIMPSON, Julie A ; KHIN ZAW AUNG ; MAKEYEVA, Galina A ; GILES, Graham G ; ENGLISH, Dallas R ; HOPPER, John ; GUYMER, Robyn H ; BAIRD, Paul N ; ROBMAN, Liubov D</creator><creatorcontrib>ADAMS, Madeleine K. M ; SIMPSON, Julie A ; KHIN ZAW AUNG ; MAKEYEVA, Galina A ; GILES, Graham G ; ENGLISH, Dallas R ; HOPPER, John ; GUYMER, Robyn H ; BAIRD, Paul N ; ROBMAN, Liubov D</creatorcontrib><description>Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, each increase of 0.1 in waist/hip ratio (~1 standard deviation) was associated with a 13% increase in the odds of early AMD (odds ratio = 1.13, 95% confidence interval: 1.01, 1.26; P = 0.03) and a 75% increase in the odds of late AMD (odds ratio = 1.75, 95% confidence interval: 1.11, 2.76; P = 0.02). No other adiposity measure was associated with early AMD for men. Smoking status modified the relation between waist/hip ratio and early AMD (P = 0.05), with no association for former smokers. For women, there were inverse associations with early AMD for all adiposity measures (odds ratios = 0.89-0.93; P = 0.002-0.02), but no associations were observed for late AMD. This study confirms abdominal obesity as an AMD risk factor for men despite a survivorship effect from competing risks in morbidity and mortality. The inverse associations for women may reflect weaker true positive associations with AMD that are insufficient to overcome the survivorship effect. New data are provided on complex interactions between environmental exposures and AMD risk.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwr005</identifier><identifier>PMID: 21422060</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Abdomen ; Adult ; Age Factors ; Aged ; Aging ; Australia - epidemiology ; Biological and medical sciences ; Body Fat Distribution ; Body Mass Index ; Epidemiology ; Female ; Gender differences ; General aspects ; Humans ; Macular degeneration ; Macular Degeneration - complications ; Macular Degeneration - epidemiology ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Obesity ; Obesity, Abdominal - complications ; Ophthalmology ; Prevalence ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retinopathies ; Risk factors ; Sex Factors ; Smoking - adverse effects</subject><ispartof>American journal of epidemiology, 2011-06, Vol.173 (11), p.1246-1255</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Jun 1, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-2917196fd354620d6e07e160fb1e4311985690f9a5f6cfaeaca0089d46df8d513</citedby><cites>FETCH-LOGICAL-c411t-2917196fd354620d6e07e160fb1e4311985690f9a5f6cfaeaca0089d46df8d513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24284865$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21422060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ADAMS, Madeleine K. M</creatorcontrib><creatorcontrib>SIMPSON, Julie A</creatorcontrib><creatorcontrib>KHIN ZAW AUNG</creatorcontrib><creatorcontrib>MAKEYEVA, Galina A</creatorcontrib><creatorcontrib>GILES, Graham G</creatorcontrib><creatorcontrib>ENGLISH, Dallas R</creatorcontrib><creatorcontrib>HOPPER, John</creatorcontrib><creatorcontrib>GUYMER, Robyn H</creatorcontrib><creatorcontrib>BAIRD, Paul N</creatorcontrib><creatorcontrib>ROBMAN, Liubov D</creatorcontrib><title>Abdominal Obesity and Age-related Macular Degeneration</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, each increase of 0.1 in waist/hip ratio (~1 standard deviation) was associated with a 13% increase in the odds of early AMD (odds ratio = 1.13, 95% confidence interval: 1.01, 1.26; P = 0.03) and a 75% increase in the odds of late AMD (odds ratio = 1.75, 95% confidence interval: 1.11, 2.76; P = 0.02). No other adiposity measure was associated with early AMD for men. Smoking status modified the relation between waist/hip ratio and early AMD (P = 0.05), with no association for former smokers. For women, there were inverse associations with early AMD for all adiposity measures (odds ratios = 0.89-0.93; P = 0.002-0.02), but no associations were observed for late AMD. This study confirms abdominal obesity as an AMD risk factor for men despite a survivorship effect from competing risks in morbidity and mortality. The inverse associations for women may reflect weaker true positive associations with AMD that are insufficient to overcome the survivorship effect. New data are provided on complex interactions between environmental exposures and AMD risk.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aging</subject><subject>Australia - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Body Fat Distribution</subject><subject>Body Mass Index</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gender differences</subject><subject>General aspects</subject><subject>Humans</subject><subject>Macular degeneration</subject><subject>Macular Degeneration - complications</subject><subject>Macular Degeneration - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Obesity</subject><subject>Obesity, Abdominal - complications</subject><subject>Ophthalmology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Retinopathies</subject><subject>Risk factors</subject><subject>Sex Factors</subject><subject>Smoking - adverse effects</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQxvEgiq4vFz-AFEEEoTpJk2lzXHwHxYuey2wzka7dVpMW8dtb2VXBi6e5_HgY_kLsSziVYLMzmvPZy3sAMGtiInWOKSqD62ICACq1CtWW2I5xDiClNbAptpTUSgHCROB05rpF3VKTPMw41v1HQq1Lps-cBm6oZ5fcUzU0FJILfuaWA_V11-6KDU9N5L3V3RFPV5eP5zfp3cP17fn0Lq20lH2qrMylRe8yo1GBQ4acJYKfSdbZ-E1h0IK3ZDxWnpgqAiis0-h84YzMdsTxcvc1dG8Dx75c1LHipqGWuyGWhbXSqBzV_xKLHG0uvzYP_8h5N4SxwIhynalCAYzoZImq0MUY2JevoV5Q-CgllF_Vy7F6uaw-4oPV4jBbsPuh35lHcLQCFCtqfKC2quOv06rQBZrsE-fpiCE</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>ADAMS, Madeleine K. 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M ; SIMPSON, Julie A ; KHIN ZAW AUNG ; MAKEYEVA, Galina A ; GILES, Graham G ; ENGLISH, Dallas R ; HOPPER, John ; GUYMER, Robyn H ; BAIRD, Paul N ; ROBMAN, Liubov D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-2917196fd354620d6e07e160fb1e4311985690f9a5f6cfaeaca0089d46df8d513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aging</topic><topic>Australia - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Body Fat Distribution</topic><topic>Body Mass Index</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gender differences</topic><topic>General aspects</topic><topic>Humans</topic><topic>Macular degeneration</topic><topic>Macular Degeneration - complications</topic><topic>Macular Degeneration - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Obesity</topic><topic>Obesity, Abdominal - complications</topic><topic>Ophthalmology</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Retinopathies</topic><topic>Risk factors</topic><topic>Sex Factors</topic><topic>Smoking - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADAMS, Madeleine K. 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M</au><au>SIMPSON, Julie A</au><au>KHIN ZAW AUNG</au><au>MAKEYEVA, Galina A</au><au>GILES, Graham G</au><au>ENGLISH, Dallas R</au><au>HOPPER, John</au><au>GUYMER, Robyn H</au><au>BAIRD, Paul N</au><au>ROBMAN, Liubov D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abdominal Obesity and Age-related Macular Degeneration</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>173</volume><issue>11</issue><spage>1246</spage><epage>1255</epage><pages>1246-1255</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, each increase of 0.1 in waist/hip ratio (~1 standard deviation) was associated with a 13% increase in the odds of early AMD (odds ratio = 1.13, 95% confidence interval: 1.01, 1.26; P = 0.03) and a 75% increase in the odds of late AMD (odds ratio = 1.75, 95% confidence interval: 1.11, 2.76; P = 0.02). No other adiposity measure was associated with early AMD for men. Smoking status modified the relation between waist/hip ratio and early AMD (P = 0.05), with no association for former smokers. For women, there were inverse associations with early AMD for all adiposity measures (odds ratios = 0.89-0.93; P = 0.002-0.02), but no associations were observed for late AMD. This study confirms abdominal obesity as an AMD risk factor for men despite a survivorship effect from competing risks in morbidity and mortality. The inverse associations for women may reflect weaker true positive associations with AMD that are insufficient to overcome the survivorship effect. New data are provided on complex interactions between environmental exposures and AMD risk.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>21422060</pmid><doi>10.1093/aje/kwr005</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Adult Age Factors Aged Aging Australia - epidemiology Biological and medical sciences Body Fat Distribution Body Mass Index Epidemiology Female Gender differences General aspects Humans Macular degeneration Macular Degeneration - complications Macular Degeneration - epidemiology Male Medical sciences Metabolic diseases Middle Aged Miscellaneous Obesity Obesity, Abdominal - complications Ophthalmology Prevalence Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Retinopathies Risk factors Sex Factors Smoking - adverse effects |
| title | Abdominal Obesity and Age-related Macular Degeneration |
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