Serum antibody response to the gH/gL/pUL128–131 five-protein complex of human cytomegalovirus (HCMV) in primary and reactivated HCMV infections

Abstract Background Recently, a new human cytomegalovirus (HCMV) glycoprotein complex has been identified and potentially proposed as a vaccine. Objective The aim of this study was to determine whether the HCMV gH/gL/pUL128–pUL130–pUL131 (gH/gL/pUL128–131) 5-protein (pentameric) complex (which has b...

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Veröffentlicht in:	Journal of clinical virology 2011-10, Vol.52 (2), p.113-118
Hauptverfasser:	Genini, Emilia, Percivalle, Elena, Sarasini, Antonella, Revello, M. Grazia, Baldanti, Fausto, Gerna, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Allergy and Immunology Antibodies, Monoclonal - immunology Antibodies, Viral - blood Biological and medical sciences Cytomegalovirus - genetics Cytomegalovirus - immunology Cytomegalovirus Infections - immunology ELISA Epithelial Cells - metabolism Epithelial Cells - virology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Viral Genetic Vectors - genetics gH/gL/pUL128–131 complex HCMV HEK293 Cells Human cytomegalovirus Human viral diseases Humans IgG antibody Immunoglobulin G - blood Infectious Disease Infectious diseases Medical sciences Membrane Glycoproteins - immunology Microbiology Miscellaneous Primary infection Transduction, Genetic Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral diseases Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Proteins - immunology Virology
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