Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells

Abstract Glioma stem cells (GSCs) are presumably major culprits for brain tumor initiation, progression, and recurrence after conventional therapies. Thus, selective targeting and eradication of GSCs may provide a promising and effective therapeutic approach. Here, we isolated a GSC-targeting (GSCT)...

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Veröffentlicht in:	Biomaterials 2011-11, Vol.32 (33), p.8518-8528
Hauptverfasser:	Beck, Samuel, Jin, Xun, Yin, Jinlong, Kim, Sung-Hak, Lee, Nam-Kyung, Oh, Se-Yeong, Jin, Xiong, Kim, Min-Kook, Kim, Eun-Bae, Son, Jee-Soo, Kim, Sung-Chan, Nam, Do-Hyun, Kim, Se-Hyuk, Kang, Sang-Kee, Kim, Hyunggee, Choi, Yun-Jaie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecule Advanced Basic Science Animals Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cell Differentiation Cell Line, Tumor Dentistry Fluorescent Antibody Technique Glioblastoma - metabolism Glioblastoma - pathology Glioma stem cells Humans Intermediate Filament Proteins - metabolism Mice Mice, Inbred BALB C Neoplastic Stem Cells - metabolism Nerve Tissue Proteins - metabolism Nestin Peptide Peptides - metabolism Phage display Protein Binding
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