Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality

The potential of three isothiocyanates, namely R,S -sulforaphane, erucin and phenethyl isothiocyanate, of two naturally occurring glucosinolates, namely glucoerucin and glucoraphanin, and of the enantiomers of sulforaphane to modulate glucuronosyl transferase and epoxide hydrolase, two major carcino...

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Veröffentlicht in:	Archives of toxicology 2011-08, Vol.85 (8), p.919-927
Hauptverfasser:	Abdull Razis, Ahmad Faizal, Bagatta, Manuela, De Nicola, Gina Rosalinda, Iori, Renato, Ioannides, Costas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Carcinogenesis, carcinogens and anticarcinogens Carcinogens Chemical agents Dose-Response Relationship, Drug Environmental Health Enzyme Induction - drug effects Enzymes Epoxide Hydrolases - biosynthesis Epoxide Hydrolases - drug effects Glucose - analogs & derivatives Glucose - chemistry Glucose - pharmacology Glucosinolates - chemistry Glucosinolates - pharmacology Glucuronosyltransferase - biosynthesis Glucuronosyltransferase - drug effects Imidoesters - chemistry Imidoesters - pharmacology Isothiocyanates - administration & dosage Isothiocyanates - pharmacology Liver Liver - drug effects Liver - metabolism Male Medical sciences Metabolites Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Phytochemicals Rats Rats, Wistar Rodents Stereoisomerism Sulfides - administration & dosage Sulfides - pharmacology Thiocyanates - administration & dosage Thiocyanates - chemistry Thiocyanates - pharmacology Toxicokinetics and Metabolism Toxicology Tumors
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