Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study
Background Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. Methods Thirty-five patients who took low-dose enteric-coated aspirin 1...
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| Veröffentlicht in: | Journal of gastroenterology 2011-07, Vol.46 (7), p.894-905 |
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| container_title | Journal of gastroenterology |
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| creator | Endo, Hiroki Higurashi, Takuma Hosono, Kunihiro Sakai, Eiji Sekino, Yusuke Iida, Hiroshi Sakamoto, Yasunari Koide, Tomoko Takahashi, Hirokazu Yoneda, Masato Tokoro, Chikako Inamori, Masahiko Abe, Yasunobu Nakajima, Atsushi |
| description | Background
Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use.
Methods
Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for more than 3 months) plus omeprazole 20 mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with
Lactobacillus casei
for 3 months (
L. casei
group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment.
Results
Twenty-five patients, including 13 in the
L. casei
group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the
L. casei
group as compared with the results in the control group (
P
= 0.039). The change from the baseline in the median number of mucosal breaks in the
L. casei
group was −2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the
L. casei
group was −228 compared with −4 in the control group (
P
= 0.026).
Conclusions
Co-administration of
L. casei
is effective for the treatment of aspirin-associated small bowel injury. |
| doi_str_mv | 10.1007/s00535-011-0410-1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_899146596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714586111</galeid><sourcerecordid>A714586111</sourcerecordid><originalsourceid>FETCH-LOGICAL-c588t-948887b99a9231ecf9244f50ef14b4cf089d73aa7d4e09a5c932aabacb4ad65d3</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7rj6A7xI0IOnXpPuZDrxtizrBwx40XOozseaIZ2MSZpl_AH7u83Qq6IoOVSoet6iql6EnlNyQQkZ3xRC-MA7QmlHGCUdfYA2lLUMl33_EG2IZKyjdGRn6Ekpe0LoQLh4jM56yvlWDGSD7q6d8xr0ESeHd6BrmkD7EJaCNRTrcc0W6mxjxSniMkMIeEq3NmAf90s-toD115yi1zik286kYjGUg8-tsBSby1sM-OBDqjhDNGn2363BOsWaUwjtW-pijk_RIweh2Gf38Rx9eXf9-epDt_v0_uPV5a7TXIjaSSaEGCcpQfYDtdrJnjHHiXWUTUw7IqQZB4DRMEskcC2HHqBtNDEwW26Gc_R67XvI6dtiS1WzL9qGANGmpSghJWVbLreNfPkXuU9Ljm04JUY-9s0A2aBXK3QDwSofXaoZ9Kmluhwp42JLKW3UxT-o9oydfbuEdb7l_xDQVaBzKiVbpw7Zz5CPihJ1cl6tzqvmvDo5r06aF_fzLtNszS_FT6sb0K9AaaV4Y_Pvhf7f9QeBarlm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>875721009</pqid></control><display><type>article</type><title>Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Endo, Hiroki ; Higurashi, Takuma ; Hosono, Kunihiro ; Sakai, Eiji ; Sekino, Yusuke ; Iida, Hiroshi ; Sakamoto, Yasunari ; Koide, Tomoko ; Takahashi, Hirokazu ; Yoneda, Masato ; Tokoro, Chikako ; Inamori, Masahiko ; Abe, Yasunobu ; Nakajima, Atsushi</creator><creatorcontrib>Endo, Hiroki ; Higurashi, Takuma ; Hosono, Kunihiro ; Sakai, Eiji ; Sekino, Yusuke ; Iida, Hiroshi ; Sakamoto, Yasunari ; Koide, Tomoko ; Takahashi, Hirokazu ; Yoneda, Masato ; Tokoro, Chikako ; Inamori, Masahiko ; Abe, Yasunobu ; Nakajima, Atsushi</creatorcontrib><description>Background
Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use.
Methods
Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for more than 3 months) plus omeprazole 20 mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with
Lactobacillus casei
for 3 months (
L. casei
group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment.
Results
Twenty-five patients, including 13 in the
L. casei
group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the
L. casei
group as compared with the results in the control group (
P
= 0.039). The change from the baseline in the median number of mucosal breaks in the
L. casei
group was −2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the
L. casei
group was −228 compared with −4 in the control group (
P
= 0.026).
Conclusions
Co-administration of
L. casei
is effective for the treatment of aspirin-associated small bowel injury.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-011-0410-1</identifier><identifier>PMID: 21556830</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Abdominal Surgery ; Aged ; Aged, 80 and over ; Analysis ; Anemia, Iron-Deficiency - chemically induced ; Anemia, Iron-Deficiency - pathology ; Anemia, Iron-Deficiency - therapy ; Anti-Ulcer Agents - administration & dosage ; Aspirin ; Aspirin - administration & dosage ; Aspirin - adverse effects ; Capsule Endoscopy ; Care and treatment ; Clinical trials ; Colorectal Surgery ; Dosage and administration ; Drug Therapy, Combination ; Female ; Gastroenterology ; Hepatology ; Humans ; Intestinal Diseases - chemically induced ; Intestinal Diseases - pathology ; Intestinal Diseases - therapy ; Intestinal Mucosa - drug effects ; Intestine, Small - drug effects ; Iron deficiency anemia ; Lactobacillus casei ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Omeprazole ; Omeprazole - administration & dosage ; Original Article—Alimentary Tract ; Pilot Projects ; Prevention ; Probiotics ; Probiotics - therapeutic use ; Prospective Studies ; Surgical Oncology ; Treatment Outcome</subject><ispartof>Journal of gastroenterology, 2011-07, Vol.46 (7), p.894-905</ispartof><rights>Springer 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-948887b99a9231ecf9244f50ef14b4cf089d73aa7d4e09a5c932aabacb4ad65d3</citedby><cites>FETCH-LOGICAL-c588t-948887b99a9231ecf9244f50ef14b4cf089d73aa7d4e09a5c932aabacb4ad65d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-011-0410-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-011-0410-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21556830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Endo, Hiroki</creatorcontrib><creatorcontrib>Higurashi, Takuma</creatorcontrib><creatorcontrib>Hosono, Kunihiro</creatorcontrib><creatorcontrib>Sakai, Eiji</creatorcontrib><creatorcontrib>Sekino, Yusuke</creatorcontrib><creatorcontrib>Iida, Hiroshi</creatorcontrib><creatorcontrib>Sakamoto, Yasunari</creatorcontrib><creatorcontrib>Koide, Tomoko</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><creatorcontrib>Tokoro, Chikako</creatorcontrib><creatorcontrib>Inamori, Masahiko</creatorcontrib><creatorcontrib>Abe, Yasunobu</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><title>Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use.
Methods
Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for more than 3 months) plus omeprazole 20 mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with
Lactobacillus casei
for 3 months (
L. casei
group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment.
Results
Twenty-five patients, including 13 in the
L. casei
group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the
L. casei
group as compared with the results in the control group (
P
= 0.039). The change from the baseline in the median number of mucosal breaks in the
L. casei
group was −2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the
L. casei
group was −228 compared with −4 in the control group (
P
= 0.026).
Conclusions
Co-administration of
L. casei
is effective for the treatment of aspirin-associated small bowel injury.</description><subject>Abdominal Surgery</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Anemia, Iron-Deficiency - chemically induced</subject><subject>Anemia, Iron-Deficiency - pathology</subject><subject>Anemia, Iron-Deficiency - therapy</subject><subject>Anti-Ulcer Agents - administration & dosage</subject><subject>Aspirin</subject><subject>Aspirin - administration & dosage</subject><subject>Aspirin - adverse effects</subject><subject>Capsule Endoscopy</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Colorectal Surgery</subject><subject>Dosage and administration</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Intestinal Diseases - chemically induced</subject><subject>Intestinal Diseases - pathology</subject><subject>Intestinal Diseases - therapy</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestine, Small - drug effects</subject><subject>Iron deficiency anemia</subject><subject>Lactobacillus casei</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Omeprazole</subject><subject>Omeprazole - administration & dosage</subject><subject>Original Article—Alimentary Tract</subject><subject>Pilot Projects</subject><subject>Prevention</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Prospective Studies</subject><subject>Surgical Oncology</subject><subject>Treatment Outcome</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU2LFDEQhoMo7rj6A7xI0IOnXpPuZDrxtizrBwx40XOozseaIZ2MSZpl_AH7u83Qq6IoOVSoet6iql6EnlNyQQkZ3xRC-MA7QmlHGCUdfYA2lLUMl33_EG2IZKyjdGRn6Ekpe0LoQLh4jM56yvlWDGSD7q6d8xr0ESeHd6BrmkD7EJaCNRTrcc0W6mxjxSniMkMIeEq3NmAf90s-toD115yi1zik286kYjGUg8-tsBSby1sM-OBDqjhDNGn2363BOsWaUwjtW-pijk_RIweh2Gf38Rx9eXf9-epDt_v0_uPV5a7TXIjaSSaEGCcpQfYDtdrJnjHHiXWUTUw7IqQZB4DRMEskcC2HHqBtNDEwW26Gc_R67XvI6dtiS1WzL9qGANGmpSghJWVbLreNfPkXuU9Ljm04JUY-9s0A2aBXK3QDwSofXaoZ9Kmluhwp42JLKW3UxT-o9oydfbuEdb7l_xDQVaBzKiVbpw7Zz5CPihJ1cl6tzqvmvDo5r06aF_fzLtNszS_FT6sb0K9AaaV4Y_Pvhf7f9QeBarlm</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Endo, Hiroki</creator><creator>Higurashi, Takuma</creator><creator>Hosono, Kunihiro</creator><creator>Sakai, Eiji</creator><creator>Sekino, Yusuke</creator><creator>Iida, Hiroshi</creator><creator>Sakamoto, Yasunari</creator><creator>Koide, Tomoko</creator><creator>Takahashi, Hirokazu</creator><creator>Yoneda, Masato</creator><creator>Tokoro, Chikako</creator><creator>Inamori, Masahiko</creator><creator>Abe, Yasunobu</creator><creator>Nakajima, Atsushi</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20110701</creationdate><title>Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study</title><author>Endo, Hiroki ; Higurashi, Takuma ; Hosono, Kunihiro ; Sakai, Eiji ; Sekino, Yusuke ; Iida, Hiroshi ; Sakamoto, Yasunari ; Koide, Tomoko ; Takahashi, Hirokazu ; Yoneda, Masato ; Tokoro, Chikako ; Inamori, Masahiko ; Abe, Yasunobu ; Nakajima, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-948887b99a9231ecf9244f50ef14b4cf089d73aa7d4e09a5c932aabacb4ad65d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal Surgery</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Anemia, Iron-Deficiency - chemically induced</topic><topic>Anemia, Iron-Deficiency - pathology</topic><topic>Anemia, Iron-Deficiency - therapy</topic><topic>Anti-Ulcer Agents - administration & dosage</topic><topic>Aspirin</topic><topic>Aspirin - administration & dosage</topic><topic>Aspirin - adverse effects</topic><topic>Capsule Endoscopy</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Colorectal Surgery</topic><topic>Dosage and administration</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Intestinal Diseases - chemically induced</topic><topic>Intestinal Diseases - pathology</topic><topic>Intestinal Diseases - therapy</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestine, Small - drug effects</topic><topic>Iron deficiency anemia</topic><topic>Lactobacillus casei</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Omeprazole</topic><topic>Omeprazole - administration & dosage</topic><topic>Original Article—Alimentary Tract</topic><topic>Pilot Projects</topic><topic>Prevention</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Prospective Studies</topic><topic>Surgical Oncology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Endo, Hiroki</creatorcontrib><creatorcontrib>Higurashi, Takuma</creatorcontrib><creatorcontrib>Hosono, Kunihiro</creatorcontrib><creatorcontrib>Sakai, Eiji</creatorcontrib><creatorcontrib>Sekino, Yusuke</creatorcontrib><creatorcontrib>Iida, Hiroshi</creatorcontrib><creatorcontrib>Sakamoto, Yasunari</creatorcontrib><creatorcontrib>Koide, Tomoko</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><creatorcontrib>Tokoro, Chikako</creatorcontrib><creatorcontrib>Inamori, Masahiko</creatorcontrib><creatorcontrib>Abe, Yasunobu</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Endo, Hiroki</au><au>Higurashi, Takuma</au><au>Hosono, Kunihiro</au><au>Sakai, Eiji</au><au>Sekino, Yusuke</au><au>Iida, Hiroshi</au><au>Sakamoto, Yasunari</au><au>Koide, Tomoko</au><au>Takahashi, Hirokazu</au><au>Yoneda, Masato</au><au>Tokoro, Chikako</au><au>Inamori, Masahiko</au><au>Abe, Yasunobu</au><au>Nakajima, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>46</volume><issue>7</issue><spage>894</spage><epage>905</epage><pages>894-905</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use.
Methods
Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for more than 3 months) plus omeprazole 20 mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with
Lactobacillus casei
for 3 months (
L. casei
group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment.
Results
Twenty-five patients, including 13 in the
L. casei
group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the
L. casei
group as compared with the results in the control group (
P
= 0.039). The change from the baseline in the median number of mucosal breaks in the
L. casei
group was −2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the
L. casei
group was −228 compared with −4 in the control group (
P
= 0.026).
Conclusions
Co-administration of
L. casei
is effective for the treatment of aspirin-associated small bowel injury.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21556830</pmid><doi>10.1007/s00535-011-0410-1</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2011-07, Vol.46 (7), p.894-905 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_899146596 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Aged Aged, 80 and over Analysis Anemia, Iron-Deficiency - chemically induced Anemia, Iron-Deficiency - pathology Anemia, Iron-Deficiency - therapy Anti-Ulcer Agents - administration & dosage Aspirin Aspirin - administration & dosage Aspirin - adverse effects Capsule Endoscopy Care and treatment Clinical trials Colorectal Surgery Dosage and administration Drug Therapy, Combination Female Gastroenterology Hepatology Humans Intestinal Diseases - chemically induced Intestinal Diseases - pathology Intestinal Diseases - therapy Intestinal Mucosa - drug effects Intestine, Small - drug effects Iron deficiency anemia Lactobacillus casei Male Medicine Medicine & Public Health Middle Aged Omeprazole Omeprazole - administration & dosage Original Article—Alimentary Tract Pilot Projects Prevention Probiotics Probiotics - therapeutic use Prospective Studies Surgical Oncology Treatment Outcome |
| title | Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study |
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