Kinetics and toxicity of liposomal and conventional amikacin in a patient with multidrug-resistant tuberculosis

The pharmacokinetics and toxicity of liposomal amikacin in a patient treated for advanced pulmonary multidrug-resistant tuberculosis are described. A dose of 20 mg/kg of liposomal amikacin was given on alternate days for 14 days and weekly thereafter for 9 weeks, for a total dose of 20.1 g in 17 div...

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Veröffentlicht in:	European journal of clinical microbiology & infectious diseases 1998-12, Vol.17 (11), p.794-797
Hauptverfasser:	WHITEHEAD, T. C, LOVERING, A. M, CROPLEY, I. M, WADE, P, DAVIDSON, R. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amikacin - administration & dosage Amikacin - adverse effects Amikacin - pharmacokinetics Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - therapeutic use Biological and medical sciences Drug Carriers Drug Therapy, Combination Humans Liposomes Male Medical sciences Mycobacterium Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Pharmacokinetics Pharmacology. Drug treatments Sputum - microbiology Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - metabolism Tuberculosis, Multidrug-Resistant - microbiology
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