Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice

► We investigated the synergistic activity of baicalein with ribavirin against influenza virus in cell culture and in mice. ► Study demonstrated that the compound inhibited the synthesis of viral matrix protein gene greater than ribavirin alone. ► Higher survival rate, lower body weight loss, fewer...

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Veröffentlicht in:	Antiviral research 2011-09, Vol.91 (3), p.314-320
Hauptverfasser:	Chen, Lili, Dou, Jie, Su, Zhenzhen, Zhou, Huimin, Wang, Hui, Zhou, Weidong, Guo, Qinglong, Zhou, Changlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Baicalein Biological and medical sciences Body Weight - drug effects Body weight loss Cell culture Cell Culture Techniques Cell Line Data processing Dogs double prime M gene Drug Combinations Drug Synergism Female Flavanones - administration & dosage Flavanones - therapeutic use Flavonoids Infection Inflammation Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - growth & development Influenza virus Kidney - cytology Kidney - drug effects Lung Lung - drug effects Lung - pathology Lung - virology matrix protein Medical sciences Mice Mice, Inbred ICR Orthomyxoviridae Infections - drug therapy Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - virology Pharmacology. Drug treatments Ribavirin Ribavirin - administration & dosage Ribavirin - therapeutic use Roots Scutellaria baicalensis Survival Survival Rate Synergistic activity Toxicity Traditional Chinese Medicine Viral Matrix Proteins - antagonists & inhibitors Viral Matrix Proteins - biosynthesis Virus Replication - drug effects
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