Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis

Indole-3-glycerol phosphate synthase (IGPS) catalyzes the irreversible ring closure of 1-( o-carboxyphenylamino)-1-deoxyribulose 5-phosphate (CdRP), through decarboxylation and dehydration steps, releasing indole-3-glycerol phosphate (IGP), the fourth step in the biosynthesis of tryptophan. This pat...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2009-06, Vol.486 (1), p.19-26
Hauptverfasser:	Czekster, Clarissa M., Neto, Brenno A.D., Lapis, Alexandre A.M., Dupont, Jairton, Santos, Diogenes S., Basso, Luiz A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-( o-Carboxyphenylamino)-1-deoxyribulose 5-phosphate Base Sequence Biophysical Phenomena Cloning, Molecular DNA Primers - genetics DNA, Bacterial - genetics Drug target Genes, Bacterial Hydrogen-Ion Concentration IGPS Indole-3-glycerol phosphate synthase Indole-3-Glycerol-Phosphate Synthase - genetics Indole-3-Glycerol-Phosphate Synthase - isolation & purification Indole-3-Glycerol-Phosphate Synthase - metabolism Kinetics Magnetic Resonance Spectroscopy Models, Chemical Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity Ribulosephosphates - chemical synthesis Ribulosephosphates - metabolism Spectrometry, Fluorescence Spectrometry, Mass, Electrospray Ionization Steady-state kinetics Thermodynamics Tuberculosis Virulence
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