Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway

Methylantcinate A (MAA) isolated from Antrodia camphorata inhibited the growth of oral cancer cell lines OEC-M1 and OC-2 in a dose-dependent manner, without cytotoxic to normal oral gingival fibroblast cells. The mechanism of growth inhibition was apoptosis induction, as shown by flow cytometric ana...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-10, Vol.20 (20), p.6145-6148
Hauptverfasser:	Tsai, Wan-Chi, Rao, Yerra Koteswara, Lin, Shih-Shen, Chou, Ming-Yung, Shen, Yi-Ting, Wu, Chih-Hao, Geethangili, Madamanchi, Yang, Chi-Chiang, Tzeng, Yew-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexins Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antrodia - chemistry Antrodia camphorata Apoptosis - drug effects Apoptosis mechanism bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biological and medical sciences Caspase 3 - metabolism Cell Line Cell Line, Tumor Cytotoxicity Fibroblasts - drug effects Fruiting Bodies, Fungal - chemistry Gene Expression Regulation, Neoplastic - drug effects General pharmacology Humans Medical sciences Methylantcinate A Mitochondria - drug effects Mouth Neoplasms - drug therapy Oral cancer Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Triterpenes - isolation & purification Triterpenes - pharmacology Up-Regulation - drug effects
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