The Th1 life cycle: molecular control of IFN-γ to IL-10 switching
Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces “intrinsic” IL-10 expression in cells...
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| Veröffentlicht in: | Trends in immunology 2011-06, Vol.32 (6), p.278-286 |
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| container_title | Trends in immunology |
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| creator | Cope, Andrew Le Friec, Gaelle Cardone, John Kemper, Claudia |
| description | Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces “intrinsic” IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field. |
| doi_str_mv | 10.1016/j.it.2011.03.010 |
| format | Article |
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IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces “intrinsic” IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. 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IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces “intrinsic” IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. 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| fulltext | fulltext |
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| ispartof | Trends in immunology, 2011-06, Vol.32 (6), p.278-286 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Allergy and Immunology Animals autoimmunity CD4-positive T-lymphocytes Cell Proliferation complement Humans immunopathology interferon-gamma Interferon-gamma - immunology interleukin-10 Interleukin-10 - immunology Interleukin-10 - secretion Signal Transduction Th1 Cells - cytology Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - secretion therapeutics |
| title | The Th1 life cycle: molecular control of IFN-γ to IL-10 switching |
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