Association of susceptibility to Takayasu arteritis in Chinese Han patients with HLA-DPB1
Abstract Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. Human leukocyte antigen (HLA) alleles play an important role in the development of TA. The association between HLA-DPB1 and TA in Chinese Han patients remains unclear. We examined the genotypes of 72 Chinese p...
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| Veröffentlicht in: | Human immunology 2011-10, Vol.72 (10), p.893-896 |
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| creator | Lv, Naqiang Dang, Aimin Wang, Zhiguang Zheng, Deyu Liu, Guozhang |
| description | Abstract Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. Human leukocyte antigen (HLA) alleles play an important role in the development of TA. The association between HLA-DPB1 and TA in Chinese Han patients remains unclear. We examined the genotypes of 72 Chinese patients with TA and 180 healthy unrelated individuals who did not have any history of chronic disease. HLA-DPB1 genotypes were determined using polymerase chain reaction sequence-specific primer (PCR-SSP). The frequencies of DPB1*09 and DPB1*1701 among the TA patients were significant higher than among the controls. The mean age of the onset of TA in patients with DPB1*1701 alleles was significant earlier than the DPB1*1701 negative patients. Our results indicated that the HLA-DPB1*09 and DPB1*1701 alleles might increase the susceptibility to TA, and the individuals possessing DPB1*1701 had the earlier onset age of the disease. Further studies on the mechanism underlying are warranted. |
| doi_str_mv | 10.1016/j.humimm.2011.05.001 |
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Human leukocyte antigen (HLA) alleles play an important role in the development of TA. The association between HLA-DPB1 and TA in Chinese Han patients remains unclear. We examined the genotypes of 72 Chinese patients with TA and 180 healthy unrelated individuals who did not have any history of chronic disease. HLA-DPB1 genotypes were determined using polymerase chain reaction sequence-specific primer (PCR-SSP). The frequencies of DPB1*09 and DPB1*1701 among the TA patients were significant higher than among the controls. The mean age of the onset of TA in patients with DPB1*1701 alleles was significant earlier than the DPB1*1701 negative patients. Our results indicated that the HLA-DPB1*09 and DPB1*1701 alleles might increase the susceptibility to TA, and the individuals possessing DPB1*1701 had the earlier onset age of the disease. Further studies on the mechanism underlying are warranted.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2011.05.001</identifier><identifier>PMID: 21658421</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age of Onset ; Alleles ; Allergy and Immunology ; Asian Continental Ancestry Group ; Case-Control Studies ; China - epidemiology ; Chinese Han population ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; HLA-DP beta-Chains - genetics ; HLA-DP beta-Chains - immunology ; HLA-DPB1 gene ; Humans ; Incidence ; Leukocytes - chemistry ; Leukocytes - cytology ; Leukocytes - immunology ; Male ; Middle Aged ; Phenotype ; Polymerase Chain Reaction ; Takayasu arteritis ; Takayasu Arteritis - ethnology ; Takayasu Arteritis - genetics ; Takayasu Arteritis - immunology ; Takayasu Arteritis - physiopathology</subject><ispartof>Human immunology, 2011-10, Vol.72 (10), p.893-896</ispartof><rights>American Society for Histocompatibility and Immunogenetics</rights><rights>2011 American Society for Histocompatibility and Immunogenetics</rights><rights>Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-bbc88a283155d38112d6ff5e8c91f1037ee5b64a4facd88fc204273f1a6cdf0f3</citedby><cites>FETCH-LOGICAL-c448t-bbc88a283155d38112d6ff5e8c91f1037ee5b64a4facd88fc204273f1a6cdf0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S019888591100108X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21658421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lv, Naqiang</creatorcontrib><creatorcontrib>Dang, Aimin</creatorcontrib><creatorcontrib>Wang, Zhiguang</creatorcontrib><creatorcontrib>Zheng, Deyu</creatorcontrib><creatorcontrib>Liu, Guozhang</creatorcontrib><title>Association of susceptibility to Takayasu arteritis in Chinese Han patients with HLA-DPB1</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Abstract Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. Human leukocyte antigen (HLA) alleles play an important role in the development of TA. The association between HLA-DPB1 and TA in Chinese Han patients remains unclear. We examined the genotypes of 72 Chinese patients with TA and 180 healthy unrelated individuals who did not have any history of chronic disease. HLA-DPB1 genotypes were determined using polymerase chain reaction sequence-specific primer (PCR-SSP). The frequencies of DPB1*09 and DPB1*1701 among the TA patients were significant higher than among the controls. The mean age of the onset of TA in patients with DPB1*1701 alleles was significant earlier than the DPB1*1701 negative patients. Our results indicated that the HLA-DPB1*09 and DPB1*1701 alleles might increase the susceptibility to TA, and the individuals possessing DPB1*1701 had the earlier onset age of the disease. Further studies on the mechanism underlying are warranted.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Alleles</subject><subject>Allergy and Immunology</subject><subject>Asian Continental Ancestry Group</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Chinese Han population</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>HLA-DP beta-Chains - genetics</subject><subject>HLA-DP beta-Chains - immunology</subject><subject>HLA-DPB1 gene</subject><subject>Humans</subject><subject>Incidence</subject><subject>Leukocytes - chemistry</subject><subject>Leukocytes - cytology</subject><subject>Leukocytes - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Polymerase Chain Reaction</subject><subject>Takayasu arteritis</subject><subject>Takayasu Arteritis - ethnology</subject><subject>Takayasu Arteritis - genetics</subject><subject>Takayasu Arteritis - immunology</subject><subject>Takayasu Arteritis - physiopathology</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2P0zAQhi0EYsvCP0DIN04JM0mcOBek0gWKVAkkFglOluOMVXfzUWwH1H-Pqy4cuMBpLs_7jubRMPYcIUfA-tUh3y-jG8e8AMQcRA6AD9gKZdNmiHX9kK0AW5lJKdor9iSEAwA00FSP2VWBtZBVgSv2bR3CbJyObp74bHlYgqFjdJ0bXDzxOPNbfadPOixc-0jeRRe4m_hm7yYKxLd64seUpikG_tPFPd_u1tnNpzf4lD2yegj07H5esy_v3t5uttnu4_sPm_UuM1UlY9Z1RkpdyBKF6EuJWPS1tYKkadEilA2R6OpKV1abXkprCqiKprSoa9NbsOU1e3npPfr5-0IhqtGlG4ZBTzQvQcm2xbItAf6DLNpKNK1IZHUhjZ9D8GTV0btR-5NCUGf76qAu9tXZvgKhkv0Ue3G_YOlG6v-EfutOwOsLQEnID0deBZPUGeqdJxNVP7t_bfi7wAxuckYPd3SicJgXPyXZClUoFKjP5w84PwBiSoP8Wv4CormstQ</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Lv, Naqiang</creator><creator>Dang, Aimin</creator><creator>Wang, Zhiguang</creator><creator>Zheng, Deyu</creator><creator>Liu, Guozhang</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20111001</creationdate><title>Association of susceptibility to Takayasu arteritis in Chinese Han patients with HLA-DPB1</title><author>Lv, Naqiang ; Dang, Aimin ; Wang, Zhiguang ; Zheng, Deyu ; Liu, Guozhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-bbc88a283155d38112d6ff5e8c91f1037ee5b64a4facd88fc204273f1a6cdf0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Alleles</topic><topic>Allergy and Immunology</topic><topic>Asian Continental Ancestry Group</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Chinese Han population</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>HLA-DP beta-Chains - genetics</topic><topic>HLA-DP beta-Chains - immunology</topic><topic>HLA-DPB1 gene</topic><topic>Humans</topic><topic>Incidence</topic><topic>Leukocytes - chemistry</topic><topic>Leukocytes - cytology</topic><topic>Leukocytes - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Polymerase Chain Reaction</topic><topic>Takayasu arteritis</topic><topic>Takayasu Arteritis - ethnology</topic><topic>Takayasu Arteritis - genetics</topic><topic>Takayasu Arteritis - immunology</topic><topic>Takayasu Arteritis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lv, Naqiang</creatorcontrib><creatorcontrib>Dang, Aimin</creatorcontrib><creatorcontrib>Wang, Zhiguang</creatorcontrib><creatorcontrib>Zheng, Deyu</creatorcontrib><creatorcontrib>Liu, Guozhang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lv, Naqiang</au><au>Dang, Aimin</au><au>Wang, Zhiguang</au><au>Zheng, Deyu</au><au>Liu, Guozhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of susceptibility to Takayasu arteritis in Chinese Han patients with HLA-DPB1</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>72</volume><issue>10</issue><spage>893</spage><epage>896</epage><pages>893-896</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>Abstract Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. Human leukocyte antigen (HLA) alleles play an important role in the development of TA. The association between HLA-DPB1 and TA in Chinese Han patients remains unclear. We examined the genotypes of 72 Chinese patients with TA and 180 healthy unrelated individuals who did not have any history of chronic disease. HLA-DPB1 genotypes were determined using polymerase chain reaction sequence-specific primer (PCR-SSP). The frequencies of DPB1*09 and DPB1*1701 among the TA patients were significant higher than among the controls. The mean age of the onset of TA in patients with DPB1*1701 alleles was significant earlier than the DPB1*1701 negative patients. Our results indicated that the HLA-DPB1*09 and DPB1*1701 alleles might increase the susceptibility to TA, and the individuals possessing DPB1*1701 had the earlier onset age of the disease. Further studies on the mechanism underlying are warranted.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21658421</pmid><doi>10.1016/j.humimm.2011.05.001</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Age of Onset Alleles Allergy and Immunology Asian Continental Ancestry Group Case-Control Studies China - epidemiology Chinese Han population Female Gene Frequency Genetic Predisposition to Disease Genotype HLA-DP beta-Chains - genetics HLA-DP beta-Chains - immunology HLA-DPB1 gene Humans Incidence Leukocytes - chemistry Leukocytes - cytology Leukocytes - immunology Male Middle Aged Phenotype Polymerase Chain Reaction Takayasu arteritis Takayasu Arteritis - ethnology Takayasu Arteritis - genetics Takayasu Arteritis - immunology Takayasu Arteritis - physiopathology |
| title | Association of susceptibility to Takayasu arteritis in Chinese Han patients with HLA-DPB1 |
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